The role of miRNA-210 in pre-eclampsia development

Jaszczuk, Ilona; Koczkodaj, Dorota; Kondracka, Adrianna; Kwaśniewska, Anna; Winkler, Izabela; Filip, Agata

doi:10.1080/07853890.2022.2071459

Cited by 30 publications

(15 citation statements)

References 57 publications

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“…It has been established that miRs form a huge network of ncRNAs. For example, miR-210 is differentially expressed in a variety of cancers and cardiovascular and inflammatory diseases, which renders miRs non-specific biomarkers of PE ( 2 , 70 , 71 ). Furthermore, PE is a disease involving multiple factors and mechanisms, which makes it difficult to identify highly specific miRs in PE ( 33 ).…”

Section: Applications Of Mirs In Pementioning

confidence: 99%

Role of microRNAs regulating trophoblast cell function in the pathogenesis of pre‑eclampsia (Review)

Ning

Chen

et al. 2022

Exp Ther Med

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Pre-eclampsia (PE) is a complicated pregnancy-specific disease and is considered the primary reason for maternal and foetal mortality and morbidity. PE has a multifactorial pathogenesis but the causes of PE remain unclear. The functions of trophoblasts, including differentiation, proliferation, migration, invasion and apoptosis, are essential for successful pregnancy. During the early stages of placental development, trophoblasts are strictly regulated by several molecular pathways; however, an imbalance of these molecular pathways can lead to severe placental lesions and pregnancy complications. Certain microRNAs (miRs) are abnormally expressed in PE, with several miRs involved in the regulation of pregnancy-associated genes. The present review discusses the miRs regulating trophoblast function, how they affect the pathogenesis of PE and evaluating the possibility of miRs in screening, diagnosis and treatment of PE. Contents1. Introduction 2. Biological characteristics and production of miRs 3. miRs are expressed in PE 4. miRs regulate the activity of trophoblasts 5. miRs regulate the stress response of trophoblasts 6. Applications of miRs in PE 7.

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Section: Applications Of Mirs In Pementioning

confidence: 99%

Role of microRNAs regulating trophoblast cell function in the pathogenesis of pre‑eclampsia (Review)

Ning

Chen

et al. 2022

Exp Ther Med

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“…At present, it is well established that hypoxia serves as an independent unfavourable prognostic factor in several tumours and leads to the ultimate failure of most anticancer therapeutics [ 4 , 5 ]. MicroRNAs (miRNAs) are classified as small non-coding, single-stranded RNAs (ribonucleic acids) which exerts essential roles in different fundamental processes through their influence on gene expression [ 6 ]. Recently, several miRNAs induced during hypoxia have been recognized and termed hypoxia-induced miRNAs or hypoxamiRs.…”

Section: Introductionmentioning

confidence: 99%

Hypoxia-induced autophagy in triple negative breast cancer: association with prognostic variables, patients’ survival and response to neoadjuvant chemotherapy

et al. 2023

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Autophagy is a cellular response to diverse stresses within tumor microenvironment (TME) such as hypoxia. It enhances cell survival and triggers resistance to therapy. This study investigated the prognostic importance of HIF-1α and miR-210 in triple negative breast cancer (TNBC). Also, we studied the relation between beclin-1 and Bcl-2 and their prognostic relevance in triple negative breast cancer. Furthermore, the involvement of hypoxia-related markers, beclin-1 and Bcl-2 in mediating resistance to neoadjuvant chemotherapy (NACT) in TNBC was evaluated. Immunohistochemistry was performed to evaluate HIF-1α, beclin-1 and Bcl-2 expression whereas, miR-210 mRNA was detected by quantitative reverse transcription PCR (q-PCR) in 60 TNBC patients. High HIF-1α expression was related to larger tumors, grade III cases, positive lymphovascular invasion, advanced stage, high Ki-67 and poor overall survival (OS). High miR-210 and negative Bcl-2 expression were related to nodal metastasis, advanced stage and poor OS. High beclin-1 was associated with grade III, nodal metastasis, advanced stage and poor OS. Also, high beclin-1 and negative Bcl-2 were significantly associated with high HIF-1α and high miR-210. High HIF- 1α, miR-210 and beclin-1 as well as negative Bcl-2 were inversely related to pathologic complete response following NACT. High beclin-1 and lack of Bcl-2 are significantly related to hypoxic TME in TNBC. High HIF-1α, miR-210, and beclin-1 expression together with lack of Bcl-2 are significantly associated with poor prognosis as well as poor response to NACT. HIF-1α and miR-210 could accurately predict response to NACT in TNBC.

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“…miRNAs are endogenous non-coding RNAs ~18–25 nucleotides (nt) in length and exert regulatory functions ( 5 ). miRNAs bind to the 3′-untranslated (UTR) region complementary to the mRNA sequence and correspondingly inhibit or repress mRNA translation ( 6 ).…”

Section: Introductionmentioning

confidence: 99%

“…miRNAs bind to the 3′-untranslated (UTR) region complementary to the mRNA sequence and correspondingly inhibit or repress mRNA translation ( 6 ). Recent studies showed that various miRNAs play major roles in the molecular mechanism of placental development ( 5 – 7 ). In addition, miRNAs are involved in the biological functions of trophoblast and endometrial epithelial cells ( 8 – 10 ).…”

Section: Introductionmentioning

confidence: 99%

miRNA-150_R-1 mediates the HIF-1/ErbB signaling pathway to regulate the adhesion of endometrial epithelial cells in cows experiencing retained placenta

Li²,

Wang³

et al. 2022

Front. Vet. Sci.

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Retained placenta (RP) refers to reproductive disorders caused by the failure of fetal membranes to be expelled 12 h after delivery in dairy cows. Postpartum adhesion of the fetal membranes to the uterus causes diseases such as mastitis or endometritis, which threatening the profitability of the dairy industry. Emerging evidence suggests that micro RNAs (miRNAs) play crucial roles in various processes, such as the occurrence and progression of fetal membranes discharge. However, the molecular mechanisms of miRNAs in RP remain unknown. In this study, we performed RNA-sequencing to characterize the expression profiles of mRNAs and miRNAs in caudal vein blood samples of postpartum Holstein cows whose fetal membranes were discharged normally or retained to identify RP-related genes and evaluate their molecular mechanisms. We identified 44 differentially expressed miRNAs (19 upregulated and 25 downregulated) and 706 differentially expressed mRNAs (325 upregulated and 381 downregulated) in the RP group compared to the normal fetal membranes discharge group. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis revealed that differentially expressed mRNAs were mainly enriched in the extracellular matrix, cell adhesion, and autoimmunity-related biological processes or pathways. Further analyses using RNA-sequencing, a dual luciferase reporter system, quantitative reverse transcription-PCR, immunofluorescence, and western blotting verified that endothelial PAS domain protein 1 (EPAS1) is regulated by miR-150_R-1 in endometrial epithelial cells. We demonstrated the relationship between EPAS1 and RP and confirmed that EPAS1 is upregulated in the blood and placenta of cows that experience RP. Further, we proposed a model of the miRNA-mRNA negative regulatory network mediated by the HIF-1/ErbB signaling pathway to show its regulatory role in RP.

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The role of miRNA-210 in pre-eclampsia development

Cited by 30 publications

References 57 publications

Role of microRNAs regulating trophoblast cell function in the pathogenesis of pre‑eclampsia (Review)

Role of microRNAs regulating trophoblast cell function in the pathogenesis of pre‑eclampsia (Review)

Hypoxia-induced autophagy in triple negative breast cancer: association with prognostic variables, patients’ survival and response to neoadjuvant chemotherapy

miRNA-150_R-1 mediates the HIF-1/ErbB signaling pathway to regulate the adhesion of endometrial epithelial cells in cows experiencing retained placenta

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