The role of miRNAs in multiple sclerosis pathogenesis, diagnosis, and therapeutic resistance

Doghish, Ahmed S.; Elazazy, Ola; Mohamed, Hend H.; Mansour, Reda M.; Ghanem, Aml; Faraag, Ahmed H.I.; Elballal, Mohammed S.; Elrebehy, Mahmoud A.; Elesawy, Ahmed E.; Abdel Mageed, Sherif S.; Mohammed, Osama A.; Nassar, Yara A.; Abulsoud, Ahmed I.; Raouf, Ahmed Amr; Abdel-Reheim, Mustafa Ahmed; Rashad, Ahmed A.; Elawady, Alaa S.; Elsisi, Ahmed Mohammed; Alsalme, Ali; Ali, Mohamed A.

doi:10.1016/j.prp.2023.154880

Cited by 14 publications

(3 citation statements)

References 276 publications

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“…One of the newest challenges regarding ncRNAs is represented by circRNAs. Even though they are the newest discovered ncRNAs involved in MS pathogenesis [11], they have not been extensively explored, and they further need to be studied in the context of the molecular pathways they are possibly involved in [159]. This issue is not just related to circRNAs; it also involves miRNAs and lcnRNAs.…”

Section: Future Perspectivesmentioning

confidence: 99%

Multiple Sclerosis: Roles of miRNA, lcnRNA, and circRNA and Their Implications in Cellular Pathways

Cipriano,

Schepici,

Mazzon

et al. 2024

IJMS

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Multiple sclerosis (MS) is a degenerative condition characterized by axonal damage and demyelination induced by autoreactive immune cells that occur in the Central Nervous System (CNS). The interaction between epigenetic changes and genetic factors can be widely involved in the onset, development, and progression of the disease. Although numerous efforts were made to discover new therapies able to prevent and improve the course of MS, definitive curative treatments have not been found yet. However, in recent years, it has been reported that non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs), acting as gene expression regulators, could be used as potential therapeutic targets or biomarkers to diagnose and fight MS. In this review, we discussed the role of miRNAs, lncRNAs, and circRNAs, as well as their expression level changes and signaling pathways that are related to preclinical and human MS studies. Hence, the investigation of ncRNAs could be important to provide additional information regarding MS pathogenesis as well as promote the discovery of new therapeutic strategies or biomarkers.

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Section: Future Perspectivesmentioning

confidence: 99%

Multiple Sclerosis: Roles of miRNA, lcnRNA, and circRNA and Their Implications in Cellular Pathways

Cipriano,

Schepici,

Mazzon

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

“…miRNA profiling and technical aspects regarding the isolation procedure of the same is not clearly resolved and lacks internal controls. The miRNA agents fail to attribute their stipulated effect in the in vivo scenario 226 . Furthermore, the drug delivery in miRNA therapy is extremely challenging.…”

Section: Conclusion and Future Outlookmentioning

confidence: 99%

“…The miRNA agents fail to attribute their stipulated effect in the in vivo scenario. 226 Furthermore, the drug delivery in miRNA therapy is extremely challenging. The miRNA drug is easily degraded in the first pass metabolism due to the action of nuclease on the miRNA.…”

Section: Conclusion and Future Outlookmentioning

confidence: 99%

Exploring the theranostic potentials of miRNA and epigenetic networks in autoimmune diseases: A comprehensive review

Nag,

Mitra,

Tripathi

et al. 2023

Immunity Inflam & Disease

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BackgroundAutoimmune diseases (AD) are severe pathophysiological ailments that are stimulated by an exaggerated immunogenic response towards self‐antigens, which can cause systemic or site‐specific organ damage. An array of complex genetic and epigenetic facets majorly contributes to the progression of AD, thus providing significant insight into the regulatory mechanism of microRNA (miRNA). miRNAs are short, non‐coding RNAs that have been identified as essential contributors to the post‐transcriptional regulation of host genome expression and as crucial regulators of a myriad of biological processes such as immune homeostasis, T helper cell differentiation, central and peripheral tolerance, and immune cell development.AimsThis article tends to deliberate and conceptualize the brief pathogenesis and pertinent epigenetic regulatory mechanism as well as miRNA networks majorly affecting five different ADs namely rheumatoid arthritis (RA), type 1 diabetes, multiple sclerosis (MS), systemic lupus erythematosus (SLE) and inflammatory bowel disorder (IBD) thereby providing novel miRNA‐based theranostic interventions.Results & DiscussionPertaining to the differential expression of miRNA attributed in target tissues and cellular bodies of innate and adaptive immunity, a paradigm of scientific expeditions suggests an optimistic correlation between immunogenic dysfunction and miRNA alterations.ConclusionTherefore, it is not astonishing that dysregulations in miRNA expression patterns are now recognized in a wide spectrum of disorders, establishing themselves as potential biomarkers and therapeutic targets. Owing to its theranostic potencies, miRNA targets have been widely utilized in the development of biosensors and other therapeutic molecules originating from the same.

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Aldehyde dehydrogenase-2 deficiency aggravates neuroinflammation, nociception, and motor impairment in a mouse model of multiple sclerosis

Evangelista,

Giardini,

Hösch

et al. 2024

Free Radical Biology and Medicine

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The role of miRNAs in multiple sclerosis pathogenesis, diagnosis, and therapeutic resistance

Cited by 14 publications

References 276 publications

Multiple Sclerosis: Roles of miRNA, lcnRNA, and circRNA and Their Implications in Cellular Pathways

Multiple Sclerosis: Roles of miRNA, lcnRNA, and circRNA and Their Implications in Cellular Pathways

Exploring the theranostic potentials of miRNA and epigenetic networks in autoimmune diseases: A comprehensive review

Aldehyde dehydrogenase-2 deficiency aggravates neuroinflammation, nociception, and motor impairment in a mouse model of multiple sclerosis

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