The Role of Mitophagy in Innate Immunity

Gkikas, Ilias; Palikaras, Konstantinos; Tavernarakis, Nektarios

doi:10.3389/fimmu.2018.01283

Cited by 183 publications

(149 citation statements)

References 182 publications

(205 reference statements)

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“…Thus, mitophagy controls a self-limiting machinery that supports homeostasis. These and other results demonstrate the key role of mitochondria in the transmission of signals of the innate immunity and position mitophagy as a key regulatory mechanism that preserves tissue homeostasis by limiting excessive inflammation [84].…”

Section: Innate Immunity and Mitochondrial Dysfunctionmentioning

confidence: 53%

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Possible Role of Mitochondrial DNA Mutations in Chronification of Inflammation: Focus on Atherosclerosis

Orekhov

Nikiforov

Ivanova

et al. 2020

JCM

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Chronification of inflammation is the process that lies at the basis of several human diseases that make up to 80% of morbidity and mortality worldwide. It can also explain a great deal of processes related to aging. Atherosclerosis is an example of the most important chronic inflammatory pathology in terms of public health impact. Atherogenesis is based on the inflammatory response of the innate immunity arising locally or focally. The main trigger for this response appears to be modified low-density lipoprotein (LDL), although other factors may also play a role. With the quick resolution of inflammation, atherosclerotic changes in the arterial wall do not occur. However, a violation of the innate immunity response can lead to chronification of local inflammation and, as a result, to atherosclerotic lesion formation. In this review, we discuss possible mechanisms of the impaired immune response with a special focus on mitochondrial dysfunction. Some mitochondrial dysfunctions may be due to mutations in mitochondrial DNA. Several mitochondrial DNA mutations leading to defective mitophagy have been identified. The regulatory role of mitophagy in the immune response has been shown in recent studies. We suggest that defective mitophagy promoted by mutations in mitochondrial DNA can cause innate immunity disorders leading to chronification of inflammation.

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Section: Innate Immunity and Mitochondrial Dysfunctionmentioning

confidence: 53%

“…The relationship between mitophagy and innate immunity is discussed in recent review articles [84,97,[144][145][146][147]. The interaction between mitophagy and innate immunity is crucial for the host's protective response to infection.…”

Section: The Role Of Mitophagy In the Innate Immunitymentioning

confidence: 99%

Possible Role of Mitochondrial DNA Mutations in Chronification of Inflammation: Focus on Atherosclerosis

Orekhov

Nikiforov

Ivanova

et al. 2020

JCM

View full text Add to dashboard Cite

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“…In fact, ROS-mediated mitochondrial injury is observed in several neurodegenerative diseases including PD (Reeve et al, 2018) or AD (Sun et al, 2008;Armand-Ugon et al, 2017), as well as in cancer (Yang et al, 2010;Zou et al, 2015), and metabolic pathologies (Liemburg-Apers et al, 2015). Both in physiological and pathological mitophagy, PTEN-induced kinase 1 (PINK1) emerged as a key regulatory pathway of mitophagy (Gkikas et al, 2018).…”

Section: Oxidative Stress and Autophagy In Alzheimer's Diseasementioning

confidence: 99%

Interplay Between Mitochondrial Oxidative Disorders and Proteostasis in Alzheimer’s Disease

et al. 2020

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Although the basis of Alzheimer's disease (AD) etiology remains unknown, oxidative stress (OS) has been recognized as a prodromal factor associated to its progression. OS refers to an imbalance between oxidant and antioxidant systems, which usually consist in an overproduction of reactive oxygen species (ROS) and reactive nitrogen species (RNS) which overwhelms the intrinsic antioxidant defenses. Due to this increased production of ROS and RNS, several biological functions such as glucose metabolism or synaptic activity are impaired. In AD, growing evidence links the ROS-mediated damages with molecular targets including mitochondrial dynamics and function, protein quality control system, and autophagic pathways, affecting the proteostasis balance. In this scenario, OS should be considered as not only a major feature in the pathophysiology of AD but also a potential target to combat the progression of the disease. In this review, we will discuss the role of OS in mitochondrial dysfunction, protein quality control systems, and autophagy associated to AD and suggest innovative therapeutic strategies based on a better understanding of the role of OS and proteostasis.

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“…Mitophagy is the degradation process of hyper fragmented mitochondria via autophagy in order to remove the damaged and defective mitochondria in cells [27].…”

Section: Introductionmentioning

confidence: 99%

Can Hinokitiol Kill Cancer Cells? Alternative Therapeutic Anticancer Agent via Autophagy and Apoptosis

Lee

Jun

2019

Korean J Clin Lab Sci.

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Cancer is genetically, metabolically and infectiously induced life threatening disorder showing aggressive growing pattern with invasive tendency. In order to prevent this global menace from jeopardizing human life, enormous studies on carcinogenesis and treatment for chemotherapy resistance have been intensively researched. Hinokitiol (-thujaplicin) extracted from heart wood of cupressaceous is a well-known bioactive compound demonstrating anti-inflammation, anti-bacteria and anti-cancer effects on several cancer types via apoptosis and autophagy. This study proposed that hinokitiol activates transcription factor EB (TFEB) nuclear translocation for autophagy and lysosomal biogenesis regardless of nutrient condition in cancer cells. Mitophagy and -catenin translocation into the nucleus under treatment of hinokitiol on non-small cell lung cancer (NSCLC) cells and HeLa cells were investigated. Hinokitiol exerted cytotoxicity on HeLa and HCC827 cells; moreover, artificially induced autophagy by overexpression of TFEB granted imperfect sustainability onto HeLa cells. Taken together, hinokitiol is the prominent autophagy inducer and activator of TFEB nuclear translocation. Alternative cancer therapy via autophagy is pros and cons since the autophagy in cancer cells is related to prevention and survival mechanism depending on nutrition. To avoid paradox of autophagy in cancer therapy, fine-tuned regulation and application of hinokitiol in due course for successful suppressing cancer cells are recommended.

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The Role of Mitophagy in Innate Immunity

Cited by 183 publications

References 182 publications

Possible Role of Mitochondrial DNA Mutations in Chronification of Inflammation: Focus on Atherosclerosis

Possible Role of Mitochondrial DNA Mutations in Chronification of Inflammation: Focus on Atherosclerosis

Interplay Between Mitochondrial Oxidative Disorders and Proteostasis in Alzheimer’s Disease

Can Hinokitiol Kill Cancer Cells? Alternative Therapeutic Anticancer Agent via Autophagy and Apoptosis

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