The role of mobile genetic elements in bacterial adaptation to xenobiotic organic compounds

Top, Eva M.; Springael, Dirk

doi:10.1016/s0958-1669(03)00066-1

Cited by 301 publications

(224 citation statements)

References 55 publications

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“…Some prokaryotic transposons -mobile DNA elements that move inside their host genome through a cut-and-paste process -carry antibiotic resistance genes [Berg, 1989, Kleckner, 1989, genes encoding toxins [So and McCarthy, 1980], or genes with new metabolic functions [Top and Springael, 2003]. Thus, transposons on the one hand contribute to an important public health threat by spreading antibiotic resistance among pathogens.…”

Section: Introductionmentioning

confidence: 99%

The early phase of a bacterial insertion sequence infection

Bichsel

Barbour

Wagner

2010

Theoretical Population Biology

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Bacterial insertion sequences are the simplest form of autonomous mobile DNA. It is unknown whether they need to have beneficial effects to infect and persist in bacterial populations, or whether horizontal gene transfer suffices for their persistence. We address this question by using branching process models to investigate the critical, early phase of an insertion sequence infection. We find that the probability of a successful infection is low and depends linearly on the difference between the rate of horizontal gene transfer and the fitness cost of the insertion sequences. Our models show that the median time to extinction of an insertion sequence that dies out is very short, while the median time for a successful infection to reach a modest population size is very long. We conclude that horizontal gene transfer is strong enough to allow the persistence of insertion sequences, although infection is an erratic and slow process.

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Section: Introductionmentioning

confidence: 99%

The early phase of a bacterial insertion sequence infection

Bichsel

Barbour

Wagner

2010

Theoretical Population Biology

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“…Consequently, HGT of genetic modules that allowed adaptation to rapidly evolving biotic interactions was frequently observed (recently reviewed by Smets and Barkay, 2005). Such interactions are, e.g., the production of antibiotics by microbes or their use by humans resulting in the spread of antibiotic resistance (McManus et al, 2002;Witte, 1998), the release of xenobiotics or new secondary metabolites and the spread of degradative genes and pathway assembly (Larraín-Linton et al, 2006;Top and Springael, 2003), or pathogenic and symbiotic interactions and the spread of genomic islands (Arnold et al, 2003;Hacker and Kaper, 2000).…”

Section: Real-time Adaptation By Hgtmentioning

confidence: 99%

“…Another example of bacterial capabilities that seem to have evolved and spread rather recently by HGT is the capability to degrade man-made xenobiotic compounds. Often the necessary degradative genes are located on IncP-1 plasmids (Top and Springael, 2003), which are the most promiscuous (or broad host range, BHR) self-transmissible plasmids characterized to date (Adamczyk and Jagura-Burdzy, 2003). The DNA sequence of IncP-1 plasmids is typically a mosaic of diverse origin, providing evidence of an active participation in horizontal gene transfer (Heuer et al, 2004;Schlüter et al, 2003;.…”

Section: Real-time Adaptation By Hgtmentioning

confidence: 99%

“…A variety of plasmids involved in chloroaniline degradation was described (Boon et al, 2001;Dejonghe et al, 2002). Recent findings strongly suggest that such MGEs play a very important role in the dissemination of degradative genes among bacteria, and thus in the natural construction of new degradative pathways (Top and Springael, 2003).…”

Section: Real-time Adaptation By Hgtmentioning

confidence: 99%

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Horizontal gene transfer between bacteria

Heuer¹,

Smalla²

2007

Environ. Biosafety Res.

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Horizontal gene transfer (HGT) refers to the acquisition of foreign genes by organisms. The occurrence of HGT among bacteria in the environment is assumed to have implications in the risk assessment of genetically modified bacteria which are released into the environment. First, introduced genetic sequences from a genetically modified bacterium could be transferred to indigenous micro-organisms and alter their genome and subsequently their ecological niche. Second, the genetically modified bacterium released into the environment might capture mobile genetic elements (MGE) from indigenous micro-organisms which could extend its ecological potential. Thus, for a risk assessment it is important to understand the extent of HGT and genome plasticity of bacteria in the environment. This review summarizes the present state of knowledge on HGT between bacteria as a crucial mechanism contributing to bacterial adaptability and diversity. In view of the use of GM crops and microbes in agricultural settings, in this mini-review we focus particularly on the presence and role of MGE in soil and plant-associated bacteria and the factors affecting gene transfer.

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“…Плазмиды разнообразны по размерам, по наборам генов, отвечающих за поддержание плазмид в клет-ке хозяина, за способность к переносу, за различные функции, определяющие, в том числе, экологически важные признаки: устойчивость к антибиоткам [5], способность к биодеградации ксенобиотиков [72], к азотфиксации и т.п. Как векторные системы плазми-ды могут участвовать в ОГПГ различными способами: 1) конъюгативный перенос, контролируемый генами самой плазмиды; 2) мобилизация неко-нъюгативных плазмид и перенос в коинтегратах Примечание: 1) в анализ включены только аннотированные гены [61].…”

Section: плазмиды и бактериофаги [4 15 26 70]unclassified

How Does the Horizontal Gene Transfer in Bacteria Occur and Than Is It Tied Up

Шестаков

2007

Ecological genetics

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Horizontal gene transfer as well as mutations, ge- nomic reorganization and gene loss is one of major driving forces of speciation and evolution of bacteria. A notion of definition of "species genome" is presented. The role of various types of mobile elements in distant gene transfer is considered. The nature of barriers for suc- cessful gene transfer on the level of molecular, cell and population processes is uncovered. A special attention is paid to the contribution of different systems of recombination. Hypothesis on the decisive role of horizontal gene transfer in genetic and ecological diversification of bacteria is discussed.

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The role of mobile genetic elements in bacterial adaptation to xenobiotic organic compounds

Cited by 301 publications

References 55 publications

The early phase of a bacterial insertion sequence infection

The early phase of a bacterial insertion sequence infection

Horizontal gene transfer between bacteria

How Does the Horizontal Gene Transfer in Bacteria Occur and Than Is It Tied Up

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