The role of morphological reactions of the regional hemocirculatory bed in pathogenesis of human diseases

Abstract

The determination of the range of norm variability, the boundaries of the transition of norm to pathology, and the study of the dynamics of the transition of adaptive reactions to pathological ones is a key link in understanding the pathogenesis and clinical manifestations of diseases in modern clinical medicine. The construction and angioarchitecture of the hemocirculatory bed are caused and directly related to the topographic and anatomical features of organogenesis, formation of the structuralfunctional units and, therefore, ensuring the functional purpose of the organ and its changes of an adaptive and pathological nature. The issues of angioarchitecture plasticity and tissue architecture of blood vessels walls of the hemocirculatory bed, in which adaptive mechanisms that compensate for hemodynamic disturbances and ensure the suffi ciency of blood circulation are implemented, need to be further developed. The identifi cation of systemic changes in vascular structural and functional modules can become an objective basis for the systemic association of diseases, the occurrence and development of which is reliably associated with the transformation of hemocirculatory architecture of organs. Determining the nature and dynamics of these changes can also contribute to the development of a systematic approach to the choice of treatment tactics and therapy for these diseases.