The determination of the range of norm variability, the boundaries of the transition of norm to pathology, and the study of the dynamics of the transition of adaptive reactions to pathological ones is a key link in understanding the pathogenesis and clinical manifestations of diseases in modern clinical medicine. The construction and angioarchitecture of the hemocirculatory bed are caused and directly related to the topographic and anatomical features of organogenesis, formation of the structuralfunctional units and, therefore, ensuring the functional purpose of the organ and its changes of an adaptive and pathological nature. The issues of angioarchitecture plasticity and tissue architecture of blood vessels walls of the hemocirculatory bed, in which adaptive mechanisms that compensate for hemodynamic disturbances and ensure the suffi ciency of blood circulation are implemented, need to be further developed. The identifi cation of systemic changes in vascular structural and functional modules can become an objective basis for the systemic association of diseases, the occurrence and development of which is reliably associated with the transformation of hemocirculatory architecture of organs. Determining the nature and dynamics of these changes can also contribute to the development of a systematic approach to the choice of treatment tactics and therapy for these diseases.

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The liver is one of the most significant organs of regulation of vital processes in the human body. The basis of coordination of metabolic processes is the blood vessel vascular bed of the liver. According to most researchers, it is the consequence of hemodynamic disorders that are the metabolic disorders that are caused and then maintained by tissue hypoxia. Modern ideas about the morphofunctional organization of the vascular bed of the liver are necessary for physicians of practical medical practice dealing with both the diagnosis of the degree of changes and the treatment of the organs of the hepato-gastro-duodenal region. Of particular practical interest for surgical interventions in the hepatobiliary zone is the knowledge of options for the formation of arteries of the liver.

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The purpose of the work - to identify patterns of changes in the morphofunctional organization of the vascular bed of the liver at different stages of development of strangulational and obturating acute small bowel obstruction (ASBO). Material and methods. The study was performed on 33 adult mongrel dogs of both sexes weighing 17-20 kg. The morphology of the liver in normal was studied on 2 (two) of those dogs. Twelve animals were simulated with a strangulational ASBO. In 12 animals, a low obturating ASBO was simulated. A morphometric method was used to assess the change in the volume of the vascular bed in terms of the degree of change in the area of the vessels per unit area. Results. In the dynamics of the development of the disease, we revealed patterns of changes in the morphofunctional organization of the vascular bed of the liver. Conclusions. In the process of formation of obturating ASBO, in spite of the absence of clinical manifestations of acute intestinal obstruction, the emergence of a basis for the development of polyorganic insufficiency has already been observed from 2 days.