The role of myostatin in chicken (Gallus domesticus) myogenic satellite cell proliferation and differentiation

McFarland, Douglas C.; Velleman, Sandra G.; Pesall, Jane E.; Liu, Caini

doi:10.1016/j.ygcen.2007.02.006

Cited by 35 publications

(21 citation statements)

References 28 publications

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“…The gene sequence has been shown to be highly conserved across vertebrate species (McPherron and Lee, 1997). Loss-of-function mutations associated with increased skeletal-muscle mass and other pleiotropic effects have been detected in several species, including cattle (Grobet et al, 1997), mice (Szabò et al, 1998), humans (Schuelke et al, 2004), sheep (Clop et al, 2006), dogs (Mosher et al, 2007), chickens (Ye et al, 2007;McFarland et al, 2007;Yang et al, 2003) and putatively pigs (Stinckens et al, 2008). These evidences support the hypothesis that also MSTN function could be highly conserved among vertebrates.…”

Section: Introductionmentioning

confidence: 72%

Sequence and polymorphism analysis of the camel (Camelus dromedarius) myostatin gene

Muzzachi

Oulmouden

Cherifi

et al. 2015

Emir. J. Food Agric

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Myostatin (MSTN), a negative regulator of skeletal muscle development in mammals, represents a key target for genetic investigations in meat-producing animals, with mutations responsible for increased skeletal-muscle mass currently described in several livestock species. Dromedary camels play a major economic role as suppliers of meat for human consumption across several countries. Notwithstanding, a comprehensive characterization of the sequence variability at the Camelus dromedarius MSTN locus was still lacking. Here we present the first extensive sequence and polymorphism analysis of the MSTN gene in the C. dromedarius species. Out of more than 3.6 kb of nucleotide sequence screened on 22 animals from 3 different Northern African regions, only 3 variant sites in the first intron were detected. The low observed diversity may reflect the evolutionary history of the species, likely developed as domesticates from a low variable wild ancestor population. Sequence identity among C. dromedarius and other Cetartiodactyla highlighted a tree topology consistent with previous reports of a closer relationship between Tylopoda and Suiformes. A close similarity between C. ferus and C. dromedarius was observed within Tylopoda. A markedly higher sequence identity between C. dromedarius and the other vertebrate species was observed at the MSTN locus compared to other genes, thus confirming it as a highly conserved target across mammals.

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Section: Introductionmentioning

confidence: 72%

Sequence and polymorphism analysis of the camel (Camelus dromedarius) myostatin gene

Muzzachi

Oulmouden

Cherifi

et al. 2015

Emir. J. Food Agric

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“…Like myostatin, IGF1 has been proposed to regulate mammalian muscle size in response to exercise and muscle loading (DeVol et al, 1990;Adams, 1998;Rennie et al, 2004;Heinemeier et al, 2007;Choi et al, 2009). In birds (primarily from studies in embryonic or neonate poultry), myostatin and IGF1 similarly appear to have functions in mediating muscle hypertrophy and hyperplasy during development (Guernec et al, 2003;Duclos, 2005;Sato et al, 2006;Kim et al, 2007;McFarland et al, 2007). Further, a previous study documented increases in pectoralis muscle mass in the non-migratory house sparrow (Passer domesticus) during the winter that were associated with decreases in myostatin mRNA and TLL-1 mRNA in pectoralis muscle, suggesting that the myostatin pathway might control seasonal changes in adult avian muscle size (Swanson et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Migration- and exercise-induced changes to flight muscle size in migratory birds and association withIGF1andmyostatinmRNA expression

Price

Bauchinger

Zajac

et al. 2011

Journal of Experimental Biology

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SUMMARYSeasonal adjustments to muscle size in migratory birds may result from preparatory physiological changes or responses to changed workloads. The mechanisms controlling these changes in size are poorly understood. We investigated some potential mediators of flight muscle size (myostatin and insulin-like growth factor, IGF1) in pectoralis muscles of wild wintering or migrating white-throated sparrows (Zonotrichia albicollis), captive white-throated sparrows that were photoperiod manipulated to be in a 'wintering' or 'migratory' (Zugunruhe) state, and captive European starlings (Sturnus vulgaris) that were either exercised for 2 weeks in a wind tunnel or untrained. Flight muscle size increased in photo-stimulated 'migrants' and in exercised starlings. Acute exercise but not long-term training caused increased expression of IGF1, but neither caused a change in expression of myostatin or its metalloprotease activator TLL1. Photo-stimulated 'migrant' sparrows demonstrated increased expression of both myostatin and IGF1, but wild sparrows exhibited no significant seasonal changes in expression of either myostatin or IGF1. Additionally, in both study species we describe several splice variants of myostatin that are shared with distantly related bird species. We demonstrate that their expression patterns are not different from those of the typical myostatin, suggesting that they have no functional importance and may be mistakes of the splicing machinery. We conclude that IGF1 is likely to be an important mediator of muscle phenotypic flexibility during acute exercise and during endogenous, seasonal preparation for migration. The role of myostatin is less clear, but its paradoxical increase in photo-stimulated 'migrants' may indicate a role in seasonal adjustments of protein turnover.

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“…Sun et al (2010) reported associations between DCN gene polymorphisms and the birth weight of cattle. Recent studies showed: (1) DCN can bind to MSTN and inhibit MSTN activity (Miura et al 2006); (2) DCN enhanced the proliferation and differentiation of myogenic cells by suppressing MSTN activity (Kishioka et al 2008); (3) MSTN administered to proliferating satellite cells depress the synthesis of DCN (McFarland et al 2007); (4) MSTN inhibits adipogenesis in 3T3-L1 cells, but could not alter lipolysis in fully differentiated adipocytes (Stolz et al 2008). However, the association between MSTN and DCN in adult muscle of cattle is still uncertain.…”

Section: Introductionmentioning

confidence: 99%

Colocalization of myostatin and decorin in bovine skeletal muscle

et al. 2011

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The objectives of this study were to investigate the expression and localization of myostatin (MSTN) and decorin (DCN) in bovine skeletal muscle and to find associations with muscle fibre and adipocyte development. Samples of two muscles, known for differences in meat quality and fibre composition, namely longissimus muscle (LD) and semitendinosus muscle (ST), were obtained from 18 months old bulls of the F 2 generation of a Charolais×Holstein cross. Individual muscle sections were stained for determination of size and type of muscle fibres and immunohistochemical detection of the proteins. The mRNA abundance and protein expression of MSTN and DCN were quantified by real-time PCR and Western blot, respectively. As expected, the ST had more fast fibres, less fibres of the intermediate and the slow type, and less intramuscular fat than the LD. Despite these differences, the mRNA and protein abundance of MSTN was comparable in both muscles. The protein abundance of MSTN inhibitors, namely MSTN propeptide and DCN, was greater in LD, which may have affected the biological activity of mature MSTN. Myostatin propeptide was detected in all muscle fibres; however the mature MSTN was detected to a much lower extent and mainly in slow fibres. Furthermore, MSTN was localized in close proximity to DCN in intermyocellular space, suggesting possible interactions between both proteins and effects on muscle structure and meat quality. The role of MSTN and DCN as well as their interactions in the determination of muscle composition needs to be further elucidated. KeywordsTierzucht 54 (2011) 2, 147-156, ISSN 0003-9438 © Leibniz Institute for Farm Animal Biology, Dummerstorf, Germany Albrecht et al.: Colocalization of myostatin and decorin in bovine skeletal

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The role of myostatin in chicken (Gallus domesticus) myogenic satellite cell proliferation and differentiation

Cited by 35 publications

References 28 publications

Sequence and polymorphism analysis of the camel (Camelus dromedarius) myostatin gene

Sequence and polymorphism analysis of the camel (Camelus dromedarius) myostatin gene

Migration- and exercise-induced changes to flight muscle size in migratory birds and association withIGF1andmyostatinmRNA expression

Colocalization of myostatin and decorin in bovine skeletal muscle

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