The role of nailfold videocapillaroscopy in patients with systemic sclerosis

Kubo, Shunsuke; Smith, Vanessa; Cutolo, Maurizio; Tanaka, Yoshiya

doi:10.1080/25785826.2018.1531189

Cited by 9 publications

(4 citation statements)

References 28 publications

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“…It was unusual that the risk of SSc-PAH was approximately 5.8 times greater in dcSSc associated with SSc-ILD, though there was no significantly greater risk of SSc-PAH in the presence of dyspnea (p = 0.064). Severe NC changes have been reported to increase the risk of SSc-PAH (36)(37)(38). Similarly, it was found that the risk of PAH was about three times greater with abnormalities in NC.…”

Section: Discussionmentioning

confidence: 87%

What do simple hematological parameters tell us in patients with systemic sclerosis?

Tezcan

Turan

Yılmaz

et al. 2020

Acta Dermatovenerologica Alpina Pannonica Et Adriatica

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Introduction: Systemic sclerosis (SSc) or scleroderma is a clinically heterogeneous disease. Autoantibodies associated with different clinical features may help in predicting organ involvement. Complete blood count (CBC) parameters and neutrophil/lymphocyte (NLR), monocyte/lymphocyte (MLR), and platelet/lymphocyte (PLR) ratios, which are considered biomarkers of systemic inflammation, have been reported many times in various rheumatologic diseases. Studies related to the usefulness of the CBC to assess the severity of SSc are still lacking. This study seeks to determine whether CBC parameters associated with organ involvement, when evaluated together with clinical features and autoantibodies, can additionally contribute to risk estimation. Methods: Adult patients with SSc (n = 130) and healthy control (n = 129) groups were enrolled in the study. Epidemiological, clinical, laboratory, and radiological findings were obtained by examining patient records. Results: PLR, NLR, and MLR were related to organ involvement. Statistically significant results were obtained with hemoglobin (≤ 13.0 g/dl), lymphocyte count (≤ 1,900 × 10 3 /ml), and mean platelet volume (≤ 8.0 fl) to estimate the risk of interstitial lung disease (p < 0.05). When the lymphocyte count was 1,400 (10 3 /ml) or less, there was a significantly greater risk of pulmonary hypertension. Neutrophil volume ≤ 141 indicated gastrointestinal tract involvement. Conclusions: Simple hematological parameters can be used for predicting SSc-related organ involvements.

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Section: Discussionmentioning

confidence: 87%

What do simple hematological parameters tell us in patients with systemic sclerosis?

Tezcan

Turan

Yılmaz

et al. 2020

Acta Dermatovenerologica Alpina Pannonica Et Adriatica

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“…So far, NVC has shown its undoubted value for the assessment and treatment of SSc [3]. According to the morphological changes revealed by NVC, 3 types of NVC patterns have been characterized: (1) an early pattern referred to as normal capillaries, with a well preserved capillary network containing only a few giant capillaries; (2) an active pattern revealed as the presence of numerous giant capillaries and hemorrhages, with only a minor decrease in capillary numbers; (3) a late pattern defned by severe loss of capillaries and extensive avascular areas; the capillary region appears disorganized and ramifed and/or bushy capillaries are present [6,7]. Tree patterns of NVC refect the diferent phases of SSc disease.…”

Section: Introductionmentioning

confidence: 99%

“…Microvascular damage occurs during the early stages of SSc and the ongoing vascular damage causes remodeling and disturbance of the capillary architecture, leading to microcirculation alterations [ 1 – 4 ]. In addition to the microvascular damage [ 5 ], SSc is associated with the damage of interstitial lung [ 6 ] and bone quality [ 7 ]. Nailfold videocapillaroscopy (NVC) is an effective tool of microcirculation examination, which is included in the 2013 guidelines of American College of Rheumatology (ACR) and European League Against Rheumatism (EULAR) for the preliminary classification of SSc [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Eye Sign is an Alternative for Evaluation of the Microcirculation in Patients with Systemic Sclerosis

Zhao

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objectives. To investigate consistency between eye sign and nailfold video capillaroscopy (NVC) in systemic sclerosis (SSc) patients and to evaluate eye sign with various parameters of disease and potential pulmonary involvement. Methods. A total of 60 SSc patients and 20 healthy individuals were enrolled. 20 SSc patients were complicated with pulmonary arterial hypertension (PAH); 20 SSc patients with interstitial lung diseases (ILD); 20 SSc patients without pulmonary involvement. All subjects were assessed using the methods of NVC and eye sign. Skin involvement was evaluated by modified Rodnan skin score (mRSS) and disease activity according to Medsger’s severity score (MSS). Clinical manifestations and the presence of autoantibodies were carefully recorded. Any correlations between were evaluated with the Spearman correlation coefficient test. Results. According to the morphological changes revealed by NVC, 3 types of NVC patterns have been characterized (early pattern, active pattern, and late pattern). Eye sign showed distinguishing morphologic changes in three patterns of NVC and pulmonary involvements (PAH vs ILD) in SSc. A positive linear correlation was found between scores of eye sign and NVC in all patients with SSc (r = 0.629, P = 0.001 ). A positive correlation of eye sign was found in all SSc patients with mRSS (r = 0.748, P = 0.045 ) and MSS (r = 0.636, P = 0.001 ). Conclusions. The study demonstrates that eye sign had a high consistency with NVC for the evaluation of the microcirculation in SSc patients and exhibited specific patterns in the early, active, and late phases of SSc. Eye sign can be used as a reliable method to classify and monitor SSc patients and replace the measurement of NVC.

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“…Одна ко поскольку со временем присоединились новые симп томы, были диагностированы системная склеродермия и синдром Шегрена. Необходимо отметить, что при системной склеродермии капилляроскопическая картина имеет характерный вид: появляются расширенные капилляры и уменьшается их число [17]. Возможно, «склеродермический» профиль капилляроскопии у нашей паци-ентки имел прогностическое значение в плане эволюции в системную склеродермию.…”

Section: прогнозunclassified

Evolution of Mixed Connective Tissue Disease in 7 Years Old Child: Clinical Case

Макарова

Вахитов

Сабирова

et al. 2020

Vopr. sovr. pediatr.

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Background. Mixed connective tissue disease (Sharp syndrome) is the rare chronic autoimmune pathology combining various features of systemic lupus erythematosus, systemic scleroderma, rheumatoid arthritis, dermatomyositis and high antibody titer to nuclear ribonucleoprotein. The mixed connective tissue disease may evolve into other systemic diseases over time. Description of any cases of mixed connective tissue disease and its evolution in Russian patients has not been published previously.Clinical Case Description. The results of observations of the child with clinical and immunological signs of the mixed connective tissue disease followed by the progression of systemic scleroderma symptoms and development of Sjogren's syndrome in the short period of time are presented in the article. Improvement (such as pain attenuation, increase in volume of movements in affected joints, decrease of Raynaud syndrome manifestations duration) was observed on treatment (methotrexate 10 mg/week with subsequent addition of prednisolone 0.75 mg/kg/day).Conclusion. Timely diagnostics of clinical signs of the systemic diseases debut is crucial for correct patient routing and for achieving of disease improvement.

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The role of nailfold videocapillaroscopy in patients with systemic sclerosis

Cited by 9 publications

References 28 publications

What do simple hematological parameters tell us in patients with systemic sclerosis?

What do simple hematological parameters tell us in patients with systemic sclerosis?

Eye Sign is an Alternative for Evaluation of the Microcirculation in Patients with Systemic Sclerosis

Evolution of Mixed Connective Tissue Disease in 7 Years Old Child: Clinical Case

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