The Role of Natural Products in Rheumatoid Arthritis: Current Knowledge of Basic In Vitro and In Vivo Research

Deligiannidou, Georgia-Eirini; Gougoula, Vasiliki; Bezirtzoglou, Eugenia; Kontogiorgis, Christos; Constantinides, Theodoros

doi:10.3390/antiox10040599

Cited by 17 publications

(5 citation statements)

References 129 publications

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“…NSAIDs were best known for inhibiting cyclooxygenases, which produce prostaglandins and thromboxanes. Its anti-inflammatory effects extend far beyond cyclooxygenase inhibition, including the inhibition of the pivotal nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) and the induction of certain types of eicosanoids, which reduced pro-inflammatory mediators such as TNF-, IL-1, and IL-6 ( Deligiannidou et al, 2021 ; Pekacar et al, 2021 ; Ladd et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

NSAID Treatment Before and on the Early Onset of Acute Kidney Injury Had an Opposite Effect on the Outcome of Patients With AKI

Wang

Liu

et al. 2022

Front. Pharmacol.

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Background: NSAIDs are one of the most frequently used medications and a risk factor for AKI. However, the optimal time of NSAIDs in patients with AKI is unknown.Methods: A secondary analysis of a multicenter, randomized clinical trial including adult inpatients with acute kidney injury was performed. Univariate, multivariate, and subgroup analyses were used to explore the impact of NSAIDs during the early onset of AKI on the outcome of patients with AKI.Results: A total of 6,030 patients with AKI were enrolled in the study. Following are the findings of the multi-factor analysis: NSAID treatments within 72 and 24 h before the onset of AKI were not associated with AKI progression, dialysis, or discharge from dialysis; only NSAID treatment within the 24-h onset of AKI was associated with these outcomes, and their OR values were independently 1.50 (95% CI: 1.02–2.19, p = 0.037), 4.20 (95% CI: 1.47–11.97, p = 0.007), and 0.71 (95% CI: 0.54–0.92, p = 0.011); only NSAID treatment within the 24-h onset of AKI would decrease the 14-day mortality, and the OR value was 0.52 (95% CI: 0.33–0.82, p = 0.005). The subgroup analysis revealed that in patients with age ≥65 years, CKD (chronic kidney disease), congestive heart failure, hypertension, and liver disease, NSAID treatments within the 24-h onset of AKI would deteriorate the outcome of patients with AKI.Conclusion: Before an early onset of AKI, NSAID treatment might be safe, but during the onset of AKI, even early NSAID treatment would deteriorate the outcome of patients with AKI.

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Section: Discussionmentioning

confidence: 99%

NSAID Treatment Before and on the Early Onset of Acute Kidney Injury Had an Opposite Effect on the Outcome of Patients With AKI

Wang

Liu

et al. 2022

Front. Pharmacol.

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“…Herbal medicines have regained popularity, drawing researchers’ attention to them. Out of these, polyphenols are the most captivating and widely studied [ 12 ].…”

Section: Biological Basis Of Rheumatoid Arthritismentioning

confidence: 99%

“…However, these treatments do not provide proper relief for patients, and there is no proper treatment for RA. Research is ongoing to discover new anti-arthritis drugs by designing new phytomedicines with fewer side effects and less toxicity [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Anti-Arthritic and Anti-Cancer Activities of Polyphenols: A Review of the Most Recent In Vitro Assays

Ali

Benfante

Stefano

et al. 2023

Life

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Polyphenols have gained widespread attention as they are effective in the prevention and management of various diseases, including cancer diseases (CD) and rheumatoid arthritis (RA). They are natural organic substances present in fruits, vegetables, and spices. Polyphenols interact with various kinds of receptors and membranes. They modulate different signal cascades and interact with the enzymes responsible for CD and RA. These interactions involve cellular machinery, from cell membranes to major nuclear components, and provide information on their beneficial effects on health. These actions provide evidence for their pharmaceutical exploitation in the treatment of CD and RA. In this review, we discuss different pathways, modulated by polyphenols, which are involved in CD and RA. A search of the most recent relevant publications was carried out with the following criteria: publication date, 2012–2022; language, English; study design, in vitro; and the investigation of polyphenols present in extra virgin olive, grapes, and spices in the context of RA and CD, including, when available, the underlying molecular mechanisms. This review is valuable for clarifying the mechanisms of polyphenols targeting the pathways of senescence and leading to the development of CD and RA treatments. Herein, we focus on research reports that emphasize antioxidant properties.

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“…In the Table 1 are presented a few examples of the most referenced compounds in PubMed over the past five years that demonstrate potential antioxidant and anti-inflammatory benefits. It should be taken into account that the list of natural products that demonstrate potential benefits in the management of RA supported by in vitro and animal studies is too extensive to cover exhaustively, and we direct the readers to other reviews on the topic (for review, see REFs [ 274 , 275 , 276 , 277 , 278 ]).…”

Section: Dietary Factors On Mitochondrial Status In Ramentioning

confidence: 99%

Mitochondrial Dysfunction and Oxidative Stress in Rheumatoid Arthritis

2022

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Control of excessive mitochondrial oxidative stress could provide new targets for both preventive and therapeutic interventions in the treatment of chronic inflammation or any pathology that develops under an inflammatory scenario, such as rheumatoid arthritis (RA). Increasing evidence has demonstrated the role of mitochondrial alterations in autoimmune diseases mainly due to the interplay between metabolism and innate immunity, but also in the modulation of inflammatory response of resident cells, such as synoviocytes. Thus, mitochondrial dysfunction derived from several danger signals could activate tricarboxylic acid (TCA) disruption, thereby favoring a vicious cycle of oxidative/mitochondrial stress. Mitochondrial dysfunction can act through modulating innate immunity via redox-sensitive inflammatory pathways or direct activation of the inflammasome. Besides, mitochondria also have a central role in regulating cell death, which is deeply altered in RA. Additionally, multiple evidence suggests that pathological processes in RA can be shaped by epigenetic mechanisms and that in turn, mitochondria are involved in epigenetic regulation. Finally, we will discuss about the involvement of some dietary components in the onset and progression of RA.

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The Role of Natural Products in Rheumatoid Arthritis: Current Knowledge of Basic In Vitro and In Vivo Research

Cited by 17 publications

References 129 publications

NSAID Treatment Before and on the Early Onset of Acute Kidney Injury Had an Opposite Effect on the Outcome of Patients With AKI

NSAID Treatment Before and on the Early Onset of Acute Kidney Injury Had an Opposite Effect on the Outcome of Patients With AKI

Anti-Arthritic and Anti-Cancer Activities of Polyphenols: A Review of the Most Recent In Vitro Assays

Mitochondrial Dysfunction and Oxidative Stress in Rheumatoid Arthritis

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