Abstract:1 We have, in the present work, studied the importance of the kidneys and the renal hypotensive agent, medullipin, in modulating the blood pressure (BP) response to bradykinin, as well as their ability to influence the balance between the NO-and the adrenergic systems superimposed on a bradykinininduced hypotension.2 The rats were pretreated with the NO-synthase inhibitor, Nw-nitro-L-arginine methyl esther (L-NAME) (0.3 g kg-1), proadifen (50 mg kg-1), an inhibitor of the medullipin-system, and nephrectomy (2… Show more
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