The Role of Neurophysiological Biomarkers in Obsessive-Compulsive Disorder

Herzog, Samuel; Brakoulias, Vlasios

doi:10.2174/0929867329666211217094941

Cited by 3 publications

(2 citation statements)

References 54 publications

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“…Published research describes conflicting results, ranging from significantly increased heart rate to no differences between individuals with OCD and healthy controls (Abbott et al, 2017). Olbrich et al (2022) provides evidence of increased sympathetic tone in individuals with OCD, and (Herzog & Brakoulias, 2022) describes the connection between decreased HRV and symptom severity of OCD. Thus, further research on heart rate regulation may play a crucial role in understanding the features of emotion dysregulation in patients with OCD.…”

Section: Introductionmentioning

confidence: 99%

“…Olbrich et al. (2022) provides evidence of increased sympathetic tone in individuals with OCD, and (Herzog & Brakoulias, 2022) describes the connection between decreased HRV and symptom severity of OCD. Thus, further research on heart rate regulation may play a crucial role in understanding the features of emotion dysregulation in patients with OCD.…”

Section: Introductionmentioning

confidence: 99%

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Temporal dynamics of autonomic nervous system responses under cognitive‐emotional workload in obsessive‐compulsive disorder

Portnova,

Khayrullina,

Martynova

2024

Psychophysiology

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Dysregulation of the autonomic nervous system (ANS) is commonly observed in various mental disorders, particularly when individuals engage in prolonged cognitive‐emotional tasks that require ANS adjustment to workload. Although the understanding of the temporal dynamics of sympathetic and parasympathetic tones in obsessive‐compulsive disorder (OCD) is limited, analyzing ANS reactions to cognitive‐emotional workload could provide valuable insights into one of the underlying causes of OCD. This study investigated the temporal dynamics of heart rate (HR) and pupil area (PA) while participants with OCD and healthy volunteers solved antisaccade tasks, with affective pictures serving as central fixation stimuli. The data of 31 individuals with OCD and 30 healthy volunteers were included in the study, comprising three separate blocks, each lasting approximately 8 min. The results revealed an increase in sympathetic tone in the OCD group, with the most noticeable rise occurring during the middle part of each block, particularly during the presentation of negative stimuli. Healthy volunteers demonstrated adaptive temporal dynamics of HR and PA from the first block to the last block of tasks, whereas individuals with OCD exhibited fewer changes over time, suggesting a reduced adaptation of the ANS sympathetic tone to cognitive‐emotional workload in OCD.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Temporal dynamics of autonomic nervous system responses under cognitive‐emotional workload in obsessive‐compulsive disorder

Portnova,

Khayrullina,

Martynova

2024

Psychophysiology

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The heart rate dynamics and antioxidant capacity under cognitive load in Obsessive-Compulsive disorder

Portnova,

Khayrulina,

Proskurnina

et al. 2024

Preprint

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The research of the oxidants-antioxidants homeostasis and its connection to autonomic nervous system (ANS) dysfunction in patients with obsessive-compulsive disorder (OCD) is a relatively uncharted field of study. We recruited 31 patients diagnosed with OCD and 29 healthy volunteers to analyze their saliva antioxidant capacity before and after a three-block behavioral task with cognitive and emotional load, during which we assessed heart rate (HR) and heart rate variability (HRV) patterns. We found that the OCD group had a significantly lower antioxidant capacity (AOC) and showed no increase in AOC after the cognitive task as compared with healthy volunteers. The notable negative correlation between HR and AOC changes led us to select two subgroups inside the OCD and control group: one with high HR and another with low HR. The AOC changes for OCD and healthy participants with high HR were similar, while OCD sub-group with low HR exhibited significantly different changes in AOC compared with the control group. Although HRV did not show a correlation with AOC, the OCD group demonstrated substantially higher increase of very low frequencies (VLF) of HRV during the cognitive task performance and significantly elevated low frequency powers of HRV expressed in normal units (LFnu). OCD sub-group with lower HR exhibited higher LFnu compared to both the patient and the control group with high HR. Our findings imply that OCD patients with elevated sympathetic tone of ANS reflected by initially increased HR show more adaptive AOC to cognitive load

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Biomarkers and Emerging Drug Targets in Neuropsychiatry (Part I)

Marazziti

2022

CMC

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The Role of Neurophysiological Biomarkers in Obsessive-Compulsive Disorder

Cited by 3 publications

References 54 publications

Temporal dynamics of autonomic nervous system responses under cognitive‐emotional workload in obsessive‐compulsive disorder

Temporal dynamics of autonomic nervous system responses under cognitive‐emotional workload in obsessive‐compulsive disorder

The heart rate dynamics and antioxidant capacity under cognitive load in Obsessive-Compulsive disorder

Biomarkers and Emerging Drug Targets in Neuropsychiatry (Part I)

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