The role of neutrophil gelatinase-associated lipocalin (NGAL) in the detection of blast lung injury in a military population

Lumley, Andrew I.; Osborn, Erik; Mellor, Adrian; LaCroix, Elise; Johnson, George L.; Wallace, Mary; Stacey, Michael; Smith, Jessi L.; Woods, David R.

doi:10.1016/j.jcrc.2017.08.047

Cited by 6 publications

(3 citation statements)

References 34 publications

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“…Sixth, an incidence of AKI could be higher among trauma population than the study population (1.5%). Urinary NGAL could differentiate AKI and no AKI within the high resource utilization cohort, indicating that it could be a confounder if using NGAL to indicate injury severity [21][22][23][24]. Thus, a generalizability of the study findings should be limited for a population with higher AKI rate in a utility of urinary NGAL.…”

Section: Plos Onementioning

confidence: 94%

Neutrophil gelatinase-associated lipocalin as a biomarker for short-term outcomes among trauma patients: A single-center observational study

et al. 2021

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Background Urinary biomarkers for organ dysfunction could predict the outcomes of severe trauma patients. However, the use of neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker of trauma is not well studied. Objectives To evaluate the association between the short-term prognosis of trauma patients and NGAL levels. Methods We conducted a single center study and compared predictive performances between NGAL levels and the trauma severity. Results A total of 104 patients were included in the study. Patients were divided into two groups based on ISS score of 16. There was no significant difference in patient characteristics based on trauma severity. However, the lactate level was significantly higher in the more severe group. There was a significant association between urinary NGAL levels and trauma severity indicators, such as intensive care unit stay (ICU) (p = 0.005) and emergency care unit (ECU) stay (p = 0.049). In addition, receiver operating curve analysis showed that as a predictor, NGAL could be used for detecting severity with moderate precision, especially for short-term outcomes (specificity 70.6 for ICU and 69.0 for ECU stay). Conclusion In this study, we revealed that the level of NGAL could predict the degree of invasiveness in trauma patients with moderate precision and estimate the duration of treatment during the acute phase. It is necessary to examine the validity of the findings of this study using a prospective, cohort, and multi-center collaborative study design.

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Section: Plos Onementioning

confidence: 94%

Neutrophil gelatinase-associated lipocalin as a biomarker for short-term outcomes among trauma patients: A single-center observational study

et al. 2021

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“…LC3B-II, Beclin 1, P62, HIF1/BNIP3 and mTOR play a critical role in autophagy induction in lung injury which can be used as theoretical guidelines for the development of protective measures against lung injury [13]. Andrew et al [14] collected blast injury cases and found that neutrophil gelatinase-associated lipocalin (NGAL) expression was negatively correlated with oxygenation index, which can be used as a biomarker for BLI diagnosis. These metabolites were used as circulating biomarkers to explore the potential mechanism of BLI.…”

Section: Introductionmentioning

confidence: 99%

Screening co-expressed target genes in rats and goats of blast lung injury through comparative transcriptomic analysis

Wang¹,

Gao²,

Fan³

et al. 2022

Preprint

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Background Blast lung injury (BLI) has been one of the most threat for human beings with the frequent occurrence of local wars, terrorist attacks and industrial explosions. The underlying mechanisms remains unclear. In this paper, transcriptome sequencing was performed in the lung tissues of the two species of goat and rat to identify the potential therapeutic targets involved in BLI. Results In this paper, the BLI models of rat and goat were successfully by validated HE-stain. Reddish edema fluid, erythrocyte, and even focal or patchy bleeding occurred in the alveolar cavity were visible under microscope. The genomic information of the two species was obtained by transcriptome sequencing. There were 83 DEGs co-expressed in rats and goats, among which 49 genes showed the same expression trend, including 38 up-regulated expression genes and 11 down-regulated expression genes. By the enrichment analysis, IL-17 signaling pathway and vascular smooth muscle contraction pathway are involved in BLI mechanism. The genes expressed in lung were screened for experimental verification, the main genes associated with BLI in both goat and rat are AGR2, ANKRD65, BPIFA1, BPIFB1 and KRT4. Conclusion In this study, the whole genomes of two species of BLI models were sequenced to dissect the basic characteristics of their genomes, laying the foundation for further investigation the mechanisms of BLI. By the genomic analysis, the expressed genes were involved in IL-17 signaling pathway and vascular smooth muscle contraction pathway associated with BLI. Finally, AGR2, ANKRD65, BPIFA1, BPIFB1 and KRT4 were highly expressed in both goat and rat BLI model, which could be used as potential target genes and may serve as biomarkers for the prognosis, diagnosis and therapy for BLI.

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“…Another study suggested that NGAL may be produced during alveolar cell damage triggered by barotrauma 12 . Recently, NGAL has been suggested as a valuable biological marker for predicting the severity and prognosis of patients with various respiratory diseases [13][14][15] .…”

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confidence: 99%

Neutrophil gelatinase-associated lipocalin as a prognostic biomarker of severe acute respiratory distress syndrome

Son

Cho

Jang

et al. 2022

Sci Rep

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Neutrophil gelatinase-associated lipocalin (NGAL) is produced in the bronchial and alveolar cells of inflamed lungs and is regarded as a potential prognostic biomarker in various respiratory diseases. However, there are no studies on patients with acute respiratory distress syndrome (ARDS). NGAL levels in serum and bronchoalveolar lavage (BAL) were measured at baseline and on day 7 in 110 patients with ARDS. Baseline NGAL levels were significantly higher in ARDS patients than in healthy controls (serum 25 [14.5–41] vs. 214 [114.5–250.3] ng/mL; BAL 90 [65–115] vs. 211 [124–244] ng/mL). In ARDS, baseline NGAL levels in serum and BAL were significantly higher in non-survivors than in survivors (p < 0.001 and p = 0.021, respectively). Baseline NGAL levels showed a fair predictive power for intensive care unit (ICU) mortality (serum area under the curve (AUC) 0.747, p < 0.001; BAL AUC 0.768, p < 0.001). In a multivariate Cox regression analysis, the baseline serum NGAL level (> 240 ng/mL) was significantly associated with ICU mortality (hazard ratio [HR] 5.39, 95% confidence interval [CI] 2.67–10.85, p < 0.001). In particular, day 7 NGAL was significantly correlated with day 7 driving pressure (serum r = 0.388, BAL r = 0.702), and 28 ventilator-free days (serum r = − 0.298, BAL r = − 0.297). Baseline NGAL has good prognostic value for ICU mortality in patients with ARDS. NGAL can be a biomarker for ventilator requirement, as it may be indicative of potential alveolar epithelial injury.

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The role of neutrophil gelatinase-associated lipocalin (NGAL) in the detection of blast lung injury in a military population

Cited by 6 publications

References 34 publications

Neutrophil gelatinase-associated lipocalin as a biomarker for short-term outcomes among trauma patients: A single-center observational study

Neutrophil gelatinase-associated lipocalin as a biomarker for short-term outcomes among trauma patients: A single-center observational study

Screening co-expressed target genes in rats and goats of blast lung injury through comparative transcriptomic analysis

Neutrophil gelatinase-associated lipocalin as a prognostic biomarker of severe acute respiratory distress syndrome

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