The Role of Nitric Oxide, K+ATP Channels, and cGMP in the Preconditioning Response of the Rabbit

Neuronal KATP channels mediate hypoxic preconditioning and reduce subsequent neonatal hypoxic–ischemic brain injury

“…Ischemic preconditioning can be chemically mimicked by the K ATP channel opener diazoxide, both in the heart (Horimoto et al, 2000) and in the brain (Munoz et al, 2003). While the site of action for diazoxide on K ATP channels remains controversial, it is generally accepted that diazoxide is a K ATP channel opener (Seino, 1999).…”

“…However, the underlying mechanism of preconditioning and/or ischemic tolerance is largely unknown. It is well established that K ATP channels play a crucial role in cytoprotection as part of ischemic preconditioning of the heart (Horimoto et al, 2000;Murry et al, 1986;Terzic, 1999), though the involvement of K ATP channels in ischemic preconditioning in the brain has not been investigated. In this study, we first reported Left: PKC level in brain from P7 animals was upregulated 6 h after hypoxic preconditioning (HPC) in comparison to control (Ctrl).…”

“…K ATP channels are involved in ischemic preconditioning in the heart (Horimoto et al, 2000;Murry et al, 1986;Terzic, 1999). K ATP channels have also long been proposed to play a role in ischemic tolerance in stroke, but their role in ischemic tolerance in neonatal hypoxicischemic brain injury has not been fully studied.…”

Regulation of Inducible Nitric Oxide Synthase in Ischemic Preconditioning of Muscle Flap in a Rat Model

“…36 Enhanced biosynthesis of NO by cNOS is essential to trigger the ischemic preconditioning phenomenon. [37][38][39][40] However, it was also reported that improved NO production by iNOS is required to mediate the antistunning and anti-infarct actions of ischemic preconditioning. 41,42 The up-regulation of this enzyme is a central mechanism whereby the myocardium protects itself from ischemia.…”

Effect of Thimerosal on Arrhythmia Induced by Coronary Ligation The Involvement of ATP-dependent Potassium Channels

“…35) Ockalli, et al 36) suggested that the diazoxideinduced anti-ischemic effect via opening of mitoK(ATP) channels was NOdependent. This suggestion supports our result showing that ATP-channel blockage is effective in antiarrhythmia induced by thimerosal.…”