The Role of Nitric Oxide in Health and Diseases

Khazan, Marjan; Hdayati, Mehdi

doi:10.5812/scimetr.20987

Cited by 31 publications

(26 citation statements)

References 81 publications

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“…An association has been found between serum/plasma NO concentrations and different diseases, including cardiovascular disease, heart failure, hypertension, diabetes and dysglycaemia, thyroid disorders, metabolic syndrome and obesity (Pacher et al 2007;Khazan & Hdayati 2015). The NO-NOS system has a broad spectrum of signalling functions.…”

Section: Introductionmentioning

confidence: 99%

“…Nitric oxide at nanomolar concentrations is beneficial, but can be toxic in higher micromolar concentrations. An association has been found between serum/plasma NO concentrations and different diseases, including cardiovascular disease, heart failure, hypertension, diabetes and dysglycaemia, thyroid disorders, metabolic syndrome and obesity (Pacher et al 2007;Khazan & Hdayati 2015). L-Arginine derivatives are widely used as inhibitors of NOS activity and thus decrease NO concentrations in biological systems.…”

Section: Introductionmentioning

confidence: 99%

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Retracted: Mathematical relationships and their consequences between rat pulse waveform parameters and blood pressure during decreasing NO bioavailability

Misak

Kristek

Tomášová

et al. 2016

Experimental Physiology

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What is the central question of this study? We wanted to find out whether the relationship between rat arterial pulse waveform (APW) parameters and blood pressure could be described by known mathematical functions and find mathematical parameters for conditions of hypertension resulting from decreased NO bioavailability. What is the main finding and its importance? We found mathematical functions and their parameters that approximate the relationships of 12 APW parameters to systolic and diastolic blood pressure in conditions of decreased NO bioavailability. The results may assign APW parameters to decreased NO bioavailability, which may have predictive or diagnostic value. Information obtained from the arterial pulse waveform (APW) is useful for characterization of the cardiovascular system in particular (patho)physiological conditions. Our goal was to find out whether the relationships between rat APW parameters could be described by simple mathematical functions and to find mathematical parameters for conditions of hypertension resulting from decreased NO bioavailability. Therefore, we explored details of 14 left carotid APW parameters of anaesthetized male Wistar rats and mathematically characterized their relationship to systolic and diastolic blood pressure (BP) in conditions of a gradual reduction in NO bioavailability after administration of l-NAME. The right jugular vein of anaesthetized Wistar rats was cannulated for l-NAME administration. The left carotid artery was cannulated to detect the APW at high resolution. Here, we show the time-dependent parallel changes of 14 APW parameters before and after i.v. administration of l-NAME and present mathematical functions that approximate the relationships of 12 APW parameters to systolic and diastolic BP. Some APW parameters had minor (e.g. heart rate) or biphasic dependence on BP (e.g. relative level of the maximum rate of ventricular pressure decrease (dP/dt )), but all relationships, within a particular range of BP, could be approximated by known regression functions, as a linear function (e.g. pulse BP), exponential decay (e.g. relative level of the maximum rate of ventricular pressure increase (dP/dt )), exponential growth (systolic area), exponential rise to a maximum (relative augmentation index) or sigmoid function (e.g. increase of relative level of dP/dt ). The mathematical functions may assign APW parameters to decreased NO bioavailability. This may have predictive or diagnostic value.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Retracted: Mathematical relationships and their consequences between rat pulse waveform parameters and blood pressure during decreasing NO bioavailability

Misak

Kristek

Tomášová

et al. 2016

Experimental Physiology

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“…NO is a biological mediator synthesized from L-arginine by nitric oxide synthase catalysis and cytotoxic to agents such as bacteria, fungi, protozoa and viruses [3,14,22] . Free radicals or reactive oxygen species are released from neutrophils and macrophages during inflammatory conditions [13] .…”

Section: Discussionmentioning

confidence: 99%

Ecthyma Contagiosa’lı Koyunlarda Paraoksonaz Aktivitesi, Total Sialik Asit ve Oksidatif Stresin Değerlendirilmesi

Deveci¹,

Kükürt²,

Uzlu³

et al. 2017

Kafkas Univ Vet Fak Derg

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Zoonoses are defined by the world health organization as diseases and infections which are transmitted naturally between vertebrate animals and human. Undestanding the zoonotic risk posed by pox viruses in companion animals is important for both human and animal health. Contagious ecthyma is highly contagious, zoonotic, viral skin disease that affects sheep, goats and some other domesticated and wild animals. In this present study was detected and evaluated levels of plasma paraoxonase activity (PON1), high-density lipoprotein (HDL), total sialic acid (TSA), malondialdehyde (MDA), nitric oxide (NO) and total blood glutathione (GSH) concentrations in healthy sheep and natural infected sheeps with ecthyma. In healthy sheep, laboratory results were determined as PON1 218.54±17.93 U/L, TSA 59.89±5.59 mg/ dL, HDL 48.4±4.88 mg/dL, MDA 8.58±0.80 μmol/L, NO 7.78±1.02 μmol/L and GSH 21.11±3.70 mg/dL. These values were found 174.92±18.68 U/L, 70.1±6.56 mg/dL, 37.9±6.47 mg/dL, 11.26±1.06 µmol/L, 12.44±1.90 µmol/L, 7.79±0.90 mg/dL respectively in sheeps wich are infected by ecthyma. As a result, it was concluded that there is oxidative stress due to imbalance between pro-oxidant and antioxidant molecules in sheep which are infected by ecthyma, and this imbalance is shaped by increasing oxidant levels. Keywords

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“…Phytochemical screening of the root and leaf extracts was carried out following standard procedures [11]. The presence of flavonoids, tannins, saponins, terpenoids, alkaloids, glycosides and steroids was tested for the leaf and root extracts.…”

Section: Phytochemical Screening Of Extractmentioning

confidence: 99%

Acute toxicity study and prevention of Nω-nitro-L-arginine methyl ester-induced hypertension by <i>Osteopermum imbricatum</i>

Tata¹,

Gwebu²,

Aremu³

et al. 2018

Trop. J. Pharm Res

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The Role of Nitric Oxide in Health and Diseases

Cited by 31 publications

References 81 publications

Retracted: Mathematical relationships and their consequences between rat pulse waveform parameters and blood pressure during decreasing NO bioavailability

Retracted: Mathematical relationships and their consequences between rat pulse waveform parameters and blood pressure during decreasing NO bioavailability

Ecthyma Contagiosa’lı Koyunlarda Paraoksonaz Aktivitesi, Total Sialik Asit ve Oksidatif Stresin Değerlendirilmesi

Acute toxicity study and prevention of Nω-nitro-L-arginine methyl ester-induced hypertension by <i>Osteopermum imbricatum</i>

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