The Role of Nitric Oxide in Regulating Intestinal Redox Status and Intestinal Epithelial Cell Functionality

Mu, Kaiwen; Sheng-wu, YU; Kitts, David D.

doi:10.3390/ijms20071755

Cited by 50 publications

(43 citation statements)

References 132 publications

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“…As a crucial regulator of chronic or acute inflammatory responses in inflammation, NO can be catalyzed via iNOS [1,22,23]. Thus, the anti-inflammatory effect is generally attributed to the decrease in NO production via suppression of iNOS activity and downregulation of iNOS expression.…”

Section: Discussionmentioning

confidence: 99%

Rice Protein Exerts Anti-Inflammatory Effect in Growing and Adult Rats via Suppressing NF-κB Pathway

Wang

Liang

et al. 2019

IJMS

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To elucidate the effect of rice protein (RP) on the depression of inflammation, growing and adult rats were fed with caseins and RP for 2 weeks. Compared with casein, RP reduced hepatic accumulations of reactive oxygen species (ROS) and nitro oxide (NO), and plasma activities of alanine transaminase (ALT) and aspartate transaminase (AST) in growing and adult rats. Intake of RP led to increased mRNA levels, and protein expressions of phosphoinositide 3 kinase (PI3K), protein kinase B (Akt), nuclear factor-κB 1 (NF-αB1), reticuloendotheliosis viral oncogene homolog A (RelA), tumor necrotic factor α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and monocyte chemoattractant protein-1 (MCP-1) were decreased, whereas hepatic expressions of interleukin-10 (IL-10) and heme oxygenase 1 (HO-1) were increased by RP. The activation of NF-κB was suppressed by RP through upregulation of inhibitory κB α (IκBα), resulting in decreased translocation of nuclear factor-κB 1 (p50) and RelA (p65) to the nucleus in RP groups. The present study demonstrates that RP exerts an anti-inflammatory effect to inhibit ROS-derived inflammation through suppression of the NF-κB pathway in growing and adult rats. Results suggest that the anti-inflammatory capacity of RP is independent of age.

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Section: Discussionmentioning

confidence: 99%

Rice Protein Exerts Anti-Inflammatory Effect in Growing and Adult Rats via Suppressing NF-κB Pathway

Wang

Liang

et al. 2019

IJMS

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“…Nitric oxide regulates intestinal epithelial cells and protects barrier integrity, supporting tight junctions. Moreover, it triggers a redox imbalance through a free radical mechanism that initiates lipid and protein oxidation reactions (Mu, Yu, & Kitts, ). Nitric oxide synthase activity has been shown to be increased in the colon mucosa from both UC and CD patients (Guihot et al, ).…”

Section: Discussionmentioning

confidence: 99%

Mucosal gene expression changes induced by anti‐TNF treatment in inflammatory bowel disease patients

Milanesi

Dobre

Manuc

et al. 2019

Drug Development Research

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In the last two decades anti‐tumor necrosis factor (anti‐TNF) therapy for inflammatory bowel disease (IBD) has been widely used to induce and maintain clinical and endoscopical remission, completely changing management of the disease. In this study, we aimed to identify gene expression changes in inflamed mucosa from Crohn's disease and ulcerative colitis patients treated with 5‐aminosalicylic acid (5‐ASA) (N = 25) or anti‐TNF agents (N = 12) compared to drug‐free IBD patients (N = 12) and non‐IBD control subjects (N = 18). The mucosal expression of 84 genes previously associated with IBD was evaluated by qPCR. We found that both therapeutic regimens induce a decrease in LCN2, NOS2, and TFF1, the levels of which are overexpressed in drug‐free patients compared to non‐IBD control subjects. Interestingly, a stronger effect of anti‐TNF drugs was observed on LCN2 and TFF1 levels. However, 5‐ASA seems to induce a more robust reduction of NOS2 expression. Moreover, we found that anti‐TNF treatment significantly increased ABCB1, leading to levels similar to those found in non‐IBD control subjects.

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“…Stilbenoids also have an important antioxidant role via activation of adenosine monophosphate (AMP)‐activated protein kinase (AMPK) and induction of NOS (Hwang, Kwon, Park, & Kim, ; Figure and Table ). As a consequence, higher production of NO by NOS contributes to NO‐mediated inhibition of oxidation of lipids and proteins (Mu et al, ).…”

Section: Antioxidant Dietary Compounds and Their Capacity To Combat Omentioning

confidence: 99%

“…Resveratrol has been shown to increase Figure 4 and Table 1). As a consequence, higher production of NO by NOS contributes to NOmediated inhibition of oxidation of lipids and proteins (Mu et al, 2019).…”

Section: Stilbenoidsmentioning

confidence: 99%

“…Increase in DDAH2 activity, in turn, is known to contribute to a decrease in levels of asymmetric dimethylarginine (ADMA), the endogenous NOS inhibitor (Tang, Hu, Chen, Deng, & Li, 2006). This drop in ADMA allows for higher production of NO by NOS and NO-mediated inhibition of oxidation of lipids and proteins (Mu et al, 2019). (Adjakly et al, 2011;Fang et al, 2005;Majid et al, 2010;Xie et al, 2014).…”

Section: A Link Between Antioxidant Properties Of Egcg and Egcg-medmentioning

confidence: 99%

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Dietary antioxidants remodel DNA methylation patterns in chronic disease

Beetch

Harandi-Zadeh

Shen

et al. 2019

British J Pharmacology

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Chronic diseases account for over 60% of all deaths worldwide according to the World Health Organization reports. Majority of cases are triggered by environmental exposures that lead to aberrant changes in the epigenome, specifically, the DNA methylation patterns. These changes result in altered expression of gene networks and activity of signalling pathways. Dietary antioxidants, including catechins, flavonoids, anthocyanins, stilbenes and carotenoids, demonstrate benefits in the prevention and/or support of therapy in chronic diseases. This review provides a comprehensive discussion of potential epigenetic mechanisms of antioxidant compounds in reversing altered patterns of DNA methylation in chronic disease. Antioxidants remodel the DNA methylation patterns through multiple mechanisms, including regulation of epigenetic enzymes and chromatin remodelling complexes. These effects can further contribute to antioxidant properties of the compounds. On the other hand, decrease in oxidative stress itself can impact DNA methylation delivering additional link between antioxidant mechanisms and epigenetic effects of the compounds. Linked Articles This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc

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The Role of Nitric Oxide in Regulating Intestinal Redox Status and Intestinal Epithelial Cell Functionality

Cited by 50 publications

References 132 publications

Rice Protein Exerts Anti-Inflammatory Effect in Growing and Adult Rats via Suppressing NF-κB Pathway

Rice Protein Exerts Anti-Inflammatory Effect in Growing and Adult Rats via Suppressing NF-κB Pathway

Mucosal gene expression changes induced by anti‐TNF treatment in inflammatory bowel disease patients

Dietary antioxidants remodel DNA methylation patterns in chronic disease

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