The role of NLRP3 inflammasome in colorectal cancer: potential therapeutic target

Vafaei, Somayeh; Taheri, Hamed; Hajimomeni, Yasamin; Yaseri, Amirhossein Fakhre; Zadeh, Firoozeh Abolhasani

doi:10.1007/s12094-022-02861-4

Cited by 30 publications

(14 citation statements)

References 77 publications

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“…It is known since 2002 that inflammasomes play a key component in innate immunity as they are responsible for releasing proinflammatory cytokines (notably IL-1β and IL-18) via activation of the Caspase-1 protease [ 15 ]. Inflammasomes are divided into three major families (NLR, PYHIN, and ALR), with NLRP3 being a key member of the first family (NOD-like-receptor family, pyrin domain-containing protein 3).…”

Section: Resultsmentioning

confidence: 99%

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The Multifaceted Role and Regulation of Nlrp3 Inflammasome in Colitis-Associated Colo-Rectal Cancer: A Systematic Review

Zaharie

Vălean

Popa

et al. 2023

IJMS

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Colitis-associated colo-rectal cancer remains the leading cause of mortality in inflammatory bowel diseases, with inflammation remaining one of the bridging points between the two pathologies. The NLRP3 inflammasome complex plays an important role in innate immunity; however, its misregulation can be responsible for the apparition of various pathologies such as ulcerative colitis. Our review focuses on the potential pathways of upregulation or downregulation of the NLRP3 complex, in addition to evaluating its role in the current clinical setting. Eighteen studies highlighted the potential pathways of NLRP3 complex regulation as well as its role in the metastatic process in colo-rectal cancer, with promising results. Further research is, however, needed in order to validate the results in a clinical setting.

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Section: Resultsmentioning

confidence: 99%

“…This can further ramp up the role of NLRP3 as a prognostic factor in the aforementioned pathologies as well as identify various methods of treatment in the chronic inflammation of the intestinal tract. Our focus will not be on the mechanisms of action, as this was discussed in the previous reviews [ 11 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

The Multifaceted Role and Regulation of Nlrp3 Inflammasome in Colitis-Associated Colo-Rectal Cancer: A Systematic Review

Zaharie

Vălean

Popa

et al. 2023

IJMS

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“…However, a recent study revealed that NLRP3 activation was associated with CRC invasion and metastasis (Deng et al, 2019). As a vital modulator of inflammation (Wang, Yang, et al, 2021), NLRP3 inflammasome could also induce CRC metastasis to the liver, and targeting of NLRP3 inflammasome might be used as a therapeutic target in CRC (Deng et al, 2019; Vafaei et al, 2022). Moreover, the inflammasome could regulate the expression of caspase‐1 and secrete IL‐1β and/or IL‐18 to participate in the human immune response and cell damage (Mangan et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Oxymatrine suppresses colorectal cancer progression by inhibiting NLRP3 inflammasome activation through mitophagy induction in vitro and in vivo

Liang

Sun

Wei

et al. 2023

Phytotherapy Research

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Chinese herb Radix sophorae tonkinensis extract oxymatrine shows anticancer effects.This study evaluated the role of oxymatrine in colorectal cancer (CRC) and the underlying molecular events in vitro and in vivo. CRC cells were treated with different doses of oxymatrine to assess cell viability, reactive oxygen species production, gene expression, and gene alterations. Meanwhile, mouse xenograft and liver metastasis models were used to assess the effects of oxymatrine using histology examination, transmission electron microscopy, and Western blot, respectively. Our results showed that oxymatrine treatment triggered CRC cell mitophagy to inhibit CRC cell growth, migration, invasion, and metastasis in vitro and in vivo. At the gene level, oxymatrine inhibited LRPPRC to promote Parkin translocation into the mitochondria and reduce the mitophagy-activated NLRP3 inflammasome. Thus, oxymatrine had an anticancer activity through LRPPRC inhibition, mitophagy induction, and NLRP3 inflammasome suppression in the CRC cell xenograft and liver metastasis models. In conclusion, the study demonstrates the oxymatrine anti-CRC activity through its unique role in regulating CRC cell mitophagy and NLRP3 inflammasome levels in vitro and in vivo.

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“…Also the colorectal cancer, which is one of the most usual cancers, starts as a tissue overgrowth on the inner part of the colon or rectum and unfortunately, the early spread of tumor cells is usually not detectable. So, the prevention of metastasis is the main focus of clinical research [4,5] . While, talin-1 protein is a potential prognostic marker in renal cell carcinoma and based on the studies, investigation its expression levels leads to the renal cancer progression and prediction [6] .…”

mentioning

confidence: 99%

Role of Serum C-C Motif Chemokine Ligand 2 Monocyte Chemotactic Activities in Patients with Non Small Cell Lung Cancer

Gao¹,

Qian²,

Zhang³

2023

IJPS

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To examine C-C motif chemokine ligand 2 chemotactic activities, expression and clinical relevance in the peripheral serum of non-small cell lung cancer patients is the objective of the study. The non-small cell lung cancer group consisted of 128 patients diagnosed with the disease in our institution between January 2018 and March 2022, while the healthy group consisted of 112 individuals. By using an enzyme-linked immunosorbent assay, the two group's peripheral serum was examined for C-C motif chemokine ligand 2 expression levels. The monocyte chemotactic activity of blood plasma from the two groups was assessed using the Transwell chamber technique after human monocytic leukaemia cell line THP-1 cells were grown. Analysis was done on C-C motif chemokine ligand 2 expression levels and the relationship between monocyte chemotactic activity and histopathological features in non-small cell lung cancer patients. Age and gender did not significantly connect with the expression level of C-C motif chemokine ligand 2 or its monocyte chemotactic activity (p>0.05); however, smoking, pathological categorization, tumor, nodes and metastases stage, tumor stage, nodes stage and tumor diameter did (p<0.05). The expression level of C-C motif chemokine ligand 2 was 235.4±25.7 pg/ml in the peripheral serum of non-small cell lung cancer patients and 45.7±10.5 pg/ml in the healthy population; the monocyte chemotactic activity of non-small cell lung cancer patients was 236.5 % and that of healthy people was 86.5 %. They differed from one other in a statistically significant way (p<0.05). In comparison to the normal control group (r=0.87), the lung cancer group's correlation coefficient between blood C-C motif chemokine ligand 2 and monocyte chemotactic activity was considerably lower (r=0.39). Patients with non-small cell lung cancer patients exhibit inadequate monocyte chemotactic activity, which may one day be targeted therapeutically.

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The role of NLRP3 inflammasome in colorectal cancer: potential therapeutic target

Cited by 30 publications

References 77 publications

The Multifaceted Role and Regulation of Nlrp3 Inflammasome in Colitis-Associated Colo-Rectal Cancer: A Systematic Review

The Multifaceted Role and Regulation of Nlrp3 Inflammasome in Colitis-Associated Colo-Rectal Cancer: A Systematic Review

Oxymatrine suppresses colorectal cancer progression by inhibiting NLRP3 inflammasome activation through mitophagy induction in vitro and in vivo

Role of Serum C-C Motif Chemokine Ligand 2 Monocyte Chemotactic Activities in Patients with Non Small Cell Lung Cancer

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