The Role of Nrf2 in the Attenuation of Cardiovascular Disease

Reuland, Danielle J.; McCord, Joe M.; Hamilton, Karyn L.

doi:10.1097/jes.0b013e3182948a1e

Cited by 45 publications

(31 citation statements)

References 37 publications

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“…For some of the materials, studies were done to show activity of the mixture, but in other cases reliance was simply made on known properties of the individual ingredients. In at least one case, Protandim (LifeVantage, Inc, Sandy, UT, USA), the complete mixture has been extensively studied, not just the individual ingredients 40,186,191–200. Study of the combined ingredients allowed demonstration of synergistic interaction between the ingredients; each of which separately was previously known to be a Nrf2 activator 191.…”

Section: Effects Of Diet Nutritional Supplements and Exercise On Thmentioning

confidence: 99%

“…Recently, a relationship between exercise and Nrf2 activation has been demonstrated 200,202–205. For example, activation of Nrf2 was induced by acute exercise in a mouse model, and exercise-induced oxidative stress was higher in Nrf2−/− mice due to lower expression of Nrf2-dependent antioxidant genes 204.…”

Section: Effects Of Diet Nutritional Supplements and Exercise On Thmentioning

confidence: 99%

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The clinical potential of influencing Nrf2 signaling in degenerative and immunological disorders

Gao¹,

Doan²,

Hybertson³

2014

CPAA

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Nuclear factor (erythroid-derived 2)-like 2 (Nrf2; encoded in humans by the NFE2L2 gene) is a transcription factor that regulates the gene expression of a wide variety of cytoprotective phase II detoxification and antioxidant enzymes through a promoter sequence known as the antioxidant-responsive element (ARE). The ARE is a promoter element found in many cytoprotective genes; therefore, Nrf2 plays a pivotal role in the ARE-driven cellular defense system against environmental stresses. Agents that target the ARE/Nrf2 pathway have been tested in a wide variety of disorders, with at least one new Nrf2-activating drug now approved by the US Food and Drug Administration. Examination of in vitro and in vivo experimental results, and taking into account recent human clinical trial results, has led to an opinion that Nrf2-activating strategies – which can include drugs, foods, dietary supplements, and exercise – are likely best targeted at disease prevention, disease recurrence prevention, or slowing of disease progression in early stage illnesses; they may also be useful as an interventional strategy. However, this rubric may be viewed even more conservatively in the pathophysiology of cancer. The activation of the Nrf2 pathway has been widely accepted as offering chemoprevention benefit, but it may be unhelpful or even harmful in the setting of established cancers. For example, Nrf2 activation might interfere with chemotherapies or radiotherapies or otherwise give tumor cells additional growth and survival advantages, unless they already possess mutations that fully activate their Nrf2 pathway constitutively. With all this in mind, the ARE/Nrf2 pathway remains of great interest as a possible target for the pharmacological control of degenerative and immunological diseases, both by activation and by inhibition, and its regulation remains a promising biological target for the development of new therapies.

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Section: Effects Of Diet Nutritional Supplements and Exercise On Thmentioning

confidence: 99%

Section: Effects Of Diet Nutritional Supplements and Exercise On Thmentioning

confidence: 99%

The clinical potential of influencing Nrf2 signaling in degenerative and immunological disorders

Gao¹,

Doan²,

Hybertson³

2014

CPAA

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“…In the developed countries CVD is one of the leading causes of death. 18 Overproduction of oxidants ameliorates the severity of the disease. Oxidative damage results into endothelial cell injuries and deleterious vasodilator effects.…”

Section: Protective Action On Cardiovascular Diseasesmentioning

confidence: 99%

Phytotherapeutic antioxidants

et al. 2020

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Plants have always been an integrated part of human life, whether we discuss about providing food or we about their medicinal value. Ethnomedicines have led to the discovery of many valuable drugs against various diseases. It has been postulated that most of the disease are related to immune system which is affected by imbalance balance between antioxidants and prooxidants or free radicals. Free radicals are the chemical entities capable of independent existence that contain one/more unpaired electrons and can be balanced by antioxidants. Antioxidants maintain the integrity and function of membrane lipids, cellular proteins, and nucleic acids and the control of signal transduction of gene expression in immune cells. For this reason, the immune cells are particularly sensitive to changes in their antioxidant status. Whenever there is imbalance between prooxidant and antioxidants they can lead to many diseases and even ameliorate the severity of disease like Alzheimer, cardiovascular disorder, cancer etc. There are evidences showing usage of plants as a potent source of antioxidants has provided a lot of support in combating various diseases, without any side effect. Various Bioflavonoids, Carotenoids, Hydroxycinnamates etc helps in scavenging the free radicals and thus proved to be immunostimulant. There are various mechanisms through which these Phyto antioxidants assisted against various disease. The present review is an attempt showing the relationship of free radicals with various diseases and immune system and the role of Phyto antioxidants against various health related conditions.

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“…Further reduction reactions can subsequently give rise to hydrogen peroxide [ 9 , 10 ], which has long been thought of as a harmful molecule; however, recently, new evidence has emerged which suggests that at low concentrations hydrogen peroxide acts as an intracellular signaling molecule involved in survival and proliferation mechanism. In contrast, exogenous ROS is produced by many environmental mediators which have demonstrated involvement in a number of pathological states including cardiovascular disease [ 11 ], chronic inflammation [ 12 ], and neurodegenerative diseases [ 13 ] as well as cancer [ 14 ].…”

Section: Oxidative Stressmentioning

confidence: 99%

Oxidative Stress Responses and NRF2 in Human Leukaemia

Abdul‐Aziz

MacEwan

Bowles

et al. 2015

Oxidative Medicine and Cellular Longevity

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Oxidative stress as a result of elevated levels of reactive oxygen species (ROS) has been observed in almost all cancers, including leukaemia, where they contribute to disease development and progression. However, cancer cells also express increased levels of antioxidant proteins which detoxify ROS. This includes glutathione, the major antioxidant in human cells, which has recently been identified to have dysregulated metabolism in human leukaemia. This suggests that critical balance of intracellular ROS levels is required for cancer cell function, growth, and survival. Nuclear factor (erythroid-derived 2)-like 2 (NRF2) transcription factor plays a dual role in cancer. Primarily, NRF2 is a transcription factor functioning to protect nonmalignant cells from malignant transformation and oxidative stress through transcriptional activation of detoxifying and antioxidant enzymes. However, once malignant transformation has occurred within a cell, NRF2 functions to protect the tumour from oxidative stress and chemotherapy-induced cytotoxicity. Moreover, inhibition of the NRF2 oxidative stress pathway in leukaemia cells renders them more sensitive to cytotoxic chemotherapy. Our improved understanding of NRF2 biology in human leukaemia may permit mechanisms by which we could potentially improve future cancer therapies. This review highlights the mechanisms by which leukaemic cells exploit the NRF2/ROS response to promote their growth and survival.

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The Role of Nrf2 in the Attenuation of Cardiovascular Disease

Cited by 45 publications

References 37 publications

The clinical potential of influencing Nrf2 signaling in degenerative and immunological disorders

The clinical potential of influencing Nrf2 signaling in degenerative and immunological disorders

Phytotherapeutic antioxidants

Oxidative Stress Responses and NRF2 in Human Leukaemia

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