The Role of Nuclear Factor-κB in Inflammatory Lung Disease

Abstract

Nuclear factor-kappaB (NF-kappaB) is one of the most important transcription factors; it has a key role in inflammatory and immune responses, cell adhesion, developmental signals, and anti-apoptosis process. Inflammatory lung diseases such as asthma and chronic obstructive pulmonary disease (COPD) are major causes of morbidity and mortality worldwide. In this review, we highlight the role of NF-kappaB in inflammatory lung disease, the strategies which block the activation of NF-kappaB, and the therapeutic approaches to treating inflammatory lung disease.

Lentinus edodesSuppresses Allergen-Induced Airway Hyperresponsiveness and Inflammation by Downregulating Nuclear Factor-kappa B Activity in a Murine Model of Allergic Asthma

“…The eukaryotic transcription factor NF-κB regulates a wide variety of target genes that encode multiple inflammatory cytokines, such as TNF-α, IL-1β, IL-4, IL-5, IL-13, ICAM-1, and VCAM-1, all of which are closely implicated in the pathogenesis of asthma, as mentioned above [8]. Our results indicate that LE exerts anti-NF-κB actions in lung tissues of OVA-challenged mice.…”

“…inducing the transcription of various proinflammatory mediators [8], we hypothesized that LE would attenuate airway inflammatory reactions by suppressing NF-κB activation. To address this issue, we first studied the nuclear translocation of the NF-κB p65 subunit in lung tissues after OVA challenge.…”

“…Nuclear factor-kappa B (NF-κB), one of the best-characterized transcription factor, is considered to be a master regulator of inflammation and immune processes and has been widely involved in the induction of asthma and other allergic disorders [8]. Its increased activity has been shown in allergen-challenged lungs as well as airway epithelial cells and macrophages of asthmatic patients [9].…”

Salidroside Attenuates Allergic Airway Inflammation Through Negative Regulation of Nuclear Factor-Kappa B and p38 Mitogen–Activated Protein Kinase

“…Nuclear factor-kappa B (NF-kB), which is the ubiquitous eukaryotic transcription factor that regulates gene expression of proinflammatory cytokines and enzymes, has a key role in inflammatory and immune responses, including asthma (3). Its increased activation has been demonstrated in the lungs after allergen challenge and in airway epithelial cells and macrophages of asthmatic patients (4).…”

Chenodeoxycholic acid attenuates ovalbumin-induced airway inflammation in murine model of asthma by inhibiting the T H 2 cytokines

“…In previous studies it has been reported that FXR significantly decrease various cytokines involved in inflammation [38,39] and FXR ligand UDCA has been shown to inhibit these actions in OVA-sensitized mouse asthma model [17], thus our results confirm previous observations. Nuclear factor kappa B (NF-kB) is a pleotropic transcription factor that plays a central role in asthma and induces the recruitment of inflammatory cells and drive antigen-induced inflammation that is important contributor to adaptive immune response [40,41]. Activation of FXR has been shown to inhibit hepatic inflammation by antagonizing the NF-kB signalling and target gene expression in vivo [19].…”