The role of nucleotides in human nutrition

Carver, Jane D.; Walker, W. Allan

doi:10.1016/0955-2863(94)00019-i

Cited by 331 publications

(242 citation statements)

References 126 publications

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“…An increase in the delayed hypersensitivity response to SRBC and to DNFB in BALB=c and DBA=2 mice fed a diet supplemented with a mixture of nucleotides and nucleosides has also been reported (Kulkarni et al, 1989;Carver & Walker, 1995;Rueda & Gil, 2000).…”

Section: Nucleotide Modulation Of the Delayed Hypersensitivity And Almentioning

confidence: 88%

“…The activity of NK cells is increased in the mice fed a diet supplemented with nucleotides respect to those fed a diet without nucleotides. Likewise, Carver has shown in human newborns, that NK cell activity at the second month of life is increased in infants fed formula supplemented with nucleotides (Carver & Walker, 1995).…”

Section: Nucleotide Modulation Of the Delayed Hypersensitivity And Almentioning

confidence: 92%

“…On the other hand, intraperitoneal administration of a nucleoside -nucleotide mixture for 14 days was associated with reduced translocation of Gramnegative enterics to the mesenteric lymph nodes and spleen in comparison to control animals. The extent of the damaged mucosa was greater in controls and these animals were more susceptible to the lethal effects of the endotoxin lipopolysaccharide from E. coli, which suggests that dietary nucleotides may block the bacterial translocation by preventing endotoxin-induced mucosal damage (Kulkarni et al, 1989;Carver & Walker, 1995, Gil, 2001.…”

Section: Dietary Nucleotides and Defence Against Infectionmentioning

confidence: 99%

“…Soluble nucleotides are present in milk from various mammals, contributing up to 20% of the non-protein nitrogen and nucleotide patterns are species specific (Gil & Uauy, 1995). Although nucleotide deficiency has not been related to any particular disease, dietary nucleotides have been reported to be beneficial for infants since they positively influence lipid metabolism, immunity, and tissue growth, development and repair (Carver & Walker, 1995;Sänchez-Pozo et al, 1999;Gil, 2001).…”

Section: Introductionmentioning

confidence: 99%

“…There is numerous evidence demonstrating that exogenous nucleotides increase the proliferative response to T cell dependent mitogens (PHA, ConA, PWM) whereas no effects are seen when B cell dependent mitogens are used; this has been reviewed extensively in previous works (Kulkarni et al, 1989;Jyonouchi et al, 1994;Carver & Walker 1995;Gil et al, 1997, Rueda & Gil, 2000Gil, 2001).…”

Section: Introductionmentioning

confidence: 99%

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Modulation of the immune response mediated by dietary nucleotides

2002

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Dietary nucleotides have been reportedly beneficial, especially for infants, since they positively influence lipid metabolism, immunity, and tissue growth, development and repair. Rapidly proliferating tissues, such as the immune system or the intestine are not able to fulfil the needs of cell nucleotides exclusively by de novo synthesis and they preferentially utilize the salvage pathway recovering nucleosides and nucleobases from blood and diet. In the present review we describe the modulatory effect of dietary nucleotides on the immune system together with some of their effects on gut-associated lymphoid tissue. Dietary nucleotides influence lymphocyte maturation, activation and proliferation. Likewise, they affect the lymphocyte subset populations in both the small intestine and blood. Moreover, they are involved in enhancing macrophage phagocytosis and delayed hypersensitivity as well as allograft and tumour responses. In addition, they contribute to the immunoglobulin response in early life, having a positive effect on infection. In fact the incidence and duration of acute diarrhoea is lower in infants fed supplemented-nucleotide formulas. The molecular mechanisms by which dietary nucleotides modulate the immune system are practically unknown. Dietary nucleotides have been shown to enhance the production and the genetic expression of IL-6 and IL-8 by foetal small intestinal explants. Dietary nucleotides may influence protein biosynthesis as well as signal membrane transduction mediated by the interaction of exogenous nucleosides and their receptors may also contribute to modulate the expression of a number of genes, some of which can directly affect the levels of intestinal cytokines.

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Section: Nucleotide Modulation Of the Delayed Hypersensitivity And Almentioning

confidence: 88%

Section: Nucleotide Modulation Of the Delayed Hypersensitivity And Almentioning

confidence: 92%

Section: Dietary Nucleotides and Defence Against Infectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Modulation of the immune response mediated by dietary nucleotides

2002

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Nutritional and toxicological evaluation of yeast (Saccharomyces cerevisiae) biomass and a yeast protein concentrate

Caballero-Córdoba¹,

Sgarbieri²

2000

J. Sci. Food Agric.

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Safety Assessment of Foods Obtained from Crops Developed Using Biotechnology

Delaney

2009

General, Applied and Systems Toxicology

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The current chapter discusses historical perspectives on the development and commercialization of genetically engineered (GE) crops developed using biotechnology, and the safety assessment of foods obtained from these crops. Most currently commercialized GE crops express transgenic proteins that confer agronomic traits, including insect resistance and herbicide tolerance that are intended to increase crop yield. Methods to assess the safety of transgenic proteins used in GE crops for potential allergenicity and toxicity are discussed. Additionally, the principles of substantial equivalence as applied to the safety assessment of foods obtained from GE crops are discussed. Numerous examples are presented to emphasize the comprehensive nature of the safety‐assessment process conducted for these products prior to commercialization to demonstrate that the transgenic proteins are safe and that the foods obtained from the currently marketed GE crops are as safe as those obtained from non‐GE crops.

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The role of nucleotides in human nutrition

Cited by 331 publications

References 126 publications

Modulation of the immune response mediated by dietary nucleotides

Modulation of the immune response mediated by dietary nucleotides

Nutritional and toxicological evaluation of yeast (Saccharomyces cerevisiae) biomass and a yeast protein concentrate

Safety Assessment of Foods Obtained from Crops Developed Using Biotechnology

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