The role of obesity in the development of atrial fibrillation: current problem status

Подзолков, В. И.; Тарзиманова, А. И.; Gataulin, R.; Оганесян, К. А.; Lobova, N. V.

doi:10.15829/1728-8800-2019-4-109-114

Cited by 10 publications

(5 citation statements)

References 50 publications

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“…При этом имеются свидетельства о связи ряда белков теплового шока, таких как HSP27, HSP60 и HSP70, с ожирением. В настоящее время значение данных маркеров изучено недостаточно, однако накоплены свидетельства о связи данной группы соединений с различными кардиоваскулярными состояниями, при этом повышенные концентрации данных белков были ассоциированы с повышенным риском развития ишемической болезни сердца, фибрилляции предсердий, артериальной гипертензии, атеросклероза [38,39].…”

Section: белки теплового шокаunclassified

Circulating biological markers of obesity: towards a systems approach

Timofeev¹,

Джиоева²,

Drapkina³

2023

Cardiovasc Ther Prev

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The pathological processes associated with obesity are based on impaired energy homeostasis, as well as excessive endocrine and paracrine activity of adipose tissue, leading to inflammation and hormonal imbalance, which is accompanied by the secretion of a wide range of compounds affecting key body processes. One of the indirect methods for assessing the adipose tissue abnormalities is the measurement of the concentration of cytokines, growth factors, as well as a class of specific compounds — adipokines specific to adipose tissue. The study of circulating biomarkers makes it possible to assess their association with the risk of complications, metabolic obesity, and other clinical and functional features. Such markers include adipokines (leptin, adiponectin, apelin, resistin, omentin, visfatin, chemerin, lipocalin, etc.), inflammation biomarkers, heat shock proteins, which are discussed in detail in this review in the context of their use in obesity and concomitant diseases.

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Section: белки теплового шокаunclassified

Circulating biological markers of obesity: towards a systems approach

Timofeev¹,

Джиоева²,

Drapkina³

2023

Cardiovasc Ther Prev

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“…There are now papers that prove a positive effect of omentin in the prevention of atrial fibrillation (AF). Tao et al showed AF patients to have the lower serum omentin than patients with sinus rhythm, and permanent AF patients to have the lowest omentin figures [51], [52].…”

Section: A Number Of Studies Established a Correlation Between Omentin Level And The Risk Of Ah Developmentmentioning

confidence: 99%

The Role of Adipokines in Cardiovascular Pathology

Подзолков

Pokrovskaya

Bazhanova

et al. 2021

Open Access Maced J Med Sci

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The recent decades saw a steady growth of obesity incidence worldwide. Obesity is an independent risk factor for cardiovascular diseases (CVDs) and type 2 diabetes mellitus and is also associated with a shorter life expectancy. Not only hemodynamic but also hormone metabolic processes, arising from excessive accumulation of adipose tissue in human body, underlie the development of CVDs. Adipose tissue has now been proved to be a hormone-active substrate. Studies of the influence of adipokines will bring us closer to understanding cardiovascular pathogenesis and help personalize prophylactic strategies.

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“…В современной литературе описаны несколько механизмов влияния избыточной массы тела на развитие аритмий: активация симпатоадреналовой нервной системы, повышение активности ренин-ангиотензинальдостероновой системы, появление АГ, инсулинорезистентность, нарушение липидного обмена, развитие системного воспаления [2][3][4][5][6][7]. Одним из наименее изученных механизмов, связанных с развитием ФП при ожирении, считают ремоделирование сердечнососудистой системы.…”

Section: Arterial Wall Stiffness In Obesity and Atrial Fibrillation ж...unclassified

Changes in Arterial Wall Stiffness in Patients with Obesity and Paroxysmal Form of Atrial Fibrillation

Подзолков

Тарзиманова

Брагина

et al. 2020

Racionalʹnaâ farmakoterapiâ v kardiologii

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Aim. To study changes in vascular wall stiffness in patients with obesity and paroxysmal atrial fibrillation (AF) during sinus rhythm retention.Material and methods. The study included 86 obese patients aged 38 to 72 years. Patients were divided into 2 groups: 42 patients with paroxysmal AF and obesity (Group I) and 44 patients with obesity and without rhythm disturbance (Group II). All patients were evaluated for the main parameters of arterial wall stiffness: the heart-ankle vascular index (CAVI) and the ankle-brachial index (ABI) in the right and left main arteries.Results. Body mass index (BMI) did not differ significantly between groups. The prevalence of visceral obesity in patients with paroxysmal AF was significantly higher than in patients without heart rhythm disorders. The study of vascular wall rigidity revealed a significant increase in the CAVI index in patients with paroxysmal AF compared with this in patients without cardiac arrhythmia. The average value of the CAVI index was 9.61±1.51 and 7.92±0.18, respectively (p=0.0003). In patients with obesity and paroxysmal AF, correlations were found between waist circumference to hip circumference (WC/HC) ratio and CAVI index (r=0.455, p=0.004); WC/height ratio and CAVI index (r=0.443, p=0.003); between WC and CAVI index (r=0.493, p=0.002). A positive direct relationship was found between CAVI index and the frequency of AF attacks during the year: r=0.782 (p=0.001).Conclusion. A significant increase in the CAVI index, indicating a change in vascular wall stiffness, was found in patients with obesity and paroxysmal AF when compared with overweight patients without heart rhythm disorders. The increase in the CAVI index was correlated with the increase in WC, the WC/HC ratio, and WC/height ratio. There was a significant direct relationship between the CAVI index and the frequency of arrhythmia attacks in patients with obesity and paroxysmal AF.

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The role of obesity in the development of atrial fibrillation: current problem status

Cited by 10 publications

References 50 publications

Circulating biological markers of obesity: towards a systems approach

Circulating biological markers of obesity: towards a systems approach

The Role of Adipokines in Cardiovascular Pathology

Changes in Arterial Wall Stiffness in Patients with Obesity and Paroxysmal Form of Atrial Fibrillation

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