The Role of Omega-3 Fatty Acids in Breast Cancer Prevention

Manni, Andrea; El‐Bayoumy, Karam; Skibinski, Christine G.; Thompson, Henry J.; Santucci-Pereira, Julia; Bidinotto, Lucas Tadeu; Russo, José

doi:10.1007/978-3-319-27135-4_3

Cited by 2 publications

(2 citation statements)

References 84 publications

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“…There was no effect of the feeding system on PUFA C18:3 n3 or C18:2 n6, though the n6/n3 ratio was the lowest in GS lambs. Even so, at 5.093, it was still higher than the recommended 4:1 ratio for promoting a human health benefit while being far lower than the 10:1 ratio that causes damage to health (n6/n3) [76]. C20:4 (arachidonic acid) is an intermediate in the metabolism of C18:2 n6 and C18:3 n3.…”

Section: Discussionmentioning

confidence: 95%

Impact of Feeding Systems on Performance, Blood Parameters, Carcass Traits, Meat Quality, and Gene Expressions of Lambs

dos Santos,

Dias Junior,

Alvarenga

et al. 2024

Agriculture

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The aim of this study was to investigate the effects of feeding systems on the growth performance of Santa Inês x Dorper lambs, meat quality, fatty acid profile, and gene expression. Thirty lambs at an initial body weight of 22.6 ± 2.59 kg were randomly assigned to one of three feed systems: a grazing system with 1.2% body weight concentrate supplementation (GS); a feedlot system with 28% forage and 72% concentrate (FFC); or feedlot with 85% whole corn grain and 15% pellets (FHG). The lambs were slaughtered after 60 days of experiment. Average daily gain, glucose, and insulin concentration were higher for lambs on FHC than lambs on a GS feeding system. The fatty acid profile in the meat of the lambs fed GS showed a higher proportion of c9t11-C18:2, C20:5, C22:5, and C22:6 compared with FFC and FHC (p < 0.05). Meat tenderness was lower for lambs under FFC treatment compared with GS and FHG. FHG treatment provides better performance and higher deposition of lipid content in meat compared with GS and FHG. The expression of the genes SCD-1, SREBP1-c, and EVOL6 was greater in lambs undergoing GS and FHC treatments compared with FFC. Results of this research showed a reduced performance of grazing lambs compared with the feedlot system; however, it enhanced the fatty acid profile with increased levels of polyunsaturated acids and reduced n6/n3 ratio.

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Section: Discussionmentioning

confidence: 95%

Impact of Feeding Systems on Performance, Blood Parameters, Carcass Traits, Meat Quality, and Gene Expressions of Lambs

dos Santos,

Dias Junior,

Alvarenga

et al. 2024

Agriculture

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“…From a mechanistic point of view, n-3FA inhibit several of the oncogenic pathways activated by obesity as summarized by us in a recent review [ 45 ]. Preclinical studies have suggested that n-3FA reduce obesity related inflammation and insulin resistance [ 46 , 47 ].…”

Section: Obesity and Breast Cancermentioning

confidence: 99%

Docosahexaenoic Acid in Combination with Dietary Energy Restriction for Reducing the Risk of Obesity Related Breast Cancer

Manni

El‐Bayoumy

Thompson

2017

IJMS

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There is strong evidence that obesity poses a significant risk factor for postmenopausal breast cancer. There are multiple mechanisms by which obesity can predispose to breast cancer, prominent among which is the creation of a pro-inflammatory milieu systemically in the visceral and subcutaneous tissue, as well as locally in the breast. Although dietary intervention studies have shown in general a favorable effect on biomarkers of breast cancer risk, it is still unclear whether losing excess weight will lower the risk. In this manuscript, we will review the evidence that omega-3 fatty acids, and among them docosahexaenoic acid (DHA) in particular, may reduce the risk of obesity related breast cancer primarily because of their pleotropic effects which target many of the systemic and local oncogenic pathways activated by excess weight. We will also review the evidence indicating that intentional weight loss (IWL) induced by dietary energy restriction (DER) will augment the tumor protective effect of DHA because of its complementary mechanisms of action and its ability to reverse the obesity-induced alterations in fatty acid metabolism predisposing to carcinogenesis. We believe that the combination of DER and DHA is a promising safe and effective intervention for reducing obesity-related breast cancer risk which needs to be validated in appropriately designed prospective, randomized clinical trials.

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The Role of Omega-3 Fatty Acids in Breast Cancer Prevention

Cited by 2 publications

References 84 publications

Impact of Feeding Systems on Performance, Blood Parameters, Carcass Traits, Meat Quality, and Gene Expressions of Lambs

Impact of Feeding Systems on Performance, Blood Parameters, Carcass Traits, Meat Quality, and Gene Expressions of Lambs

Docosahexaenoic Acid in Combination with Dietary Energy Restriction for Reducing the Risk of Obesity Related Breast Cancer

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