Mastering the “Biophysics” discipline, Bachelor students of technological specialities need a deeper understanding of the physical processes that occur in biological systems. According to the educational programme, as a result of studying biophysics, Bachelor students of technological specialities develop programme competencies. Considering the orientation of the education system to the competence approach and the needs of the present in the development of distance education, the relevant issue is the development of a structural-methodological plan for the development of professional competencies in Bachelor students of technological specialities in the context of studying biophysics during distance learning. The purpose of the paper is to form professional competencies in the study of biophysics in Bachelor students of technological specialities in the context of distance learning. The research work uses the following methods: survey, analysis of the quality of educational results, and statistical processing of results using a nonparametric statistical Mann-Whitney U-test Programme competencies in the study of biophysics in Bachelor students of technological specialities in the context of distance learning are outlined. It is proved that the distance course should contain information for conducting distance lectures, laboratory work, and practical classes. It is noted that the distance course should provide for the control of acquired knowledge during distance learning for Bachelor students of technological specialities based on test tasks, practical tests, and virtual-practical simulators. It is proved that test tasks, control sections and virtual-practical simulators provide monitoring of the results of educational activities of applicants for the higher education of technological specialities in the context of studying the “Biophysics” discipline in terms of qualitative and quantitative indicators: acquisition of competencies and obtaining points on the ECTS scale. The practical significance of the study is that as a result of such consistent work, the plan of which is covered, professional competencies are formed in Bachelor students of technical specialities in the context of studying biophysics during distance learning