The role of oxidative stress in perinatal hypoxic-ischemic brain injury

Vasiljević, Brankica; Maglajlić-Djukić, Svjetlana; Gojnić, M; Stanković, Sanja

doi:10.2298/sarh1202035v

Cited by 33 publications

(29 citation statements)

References 24 publications

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“…Thus, conditions such as hypoxic ischemic encephalopathy have been associated with increased generation of free radicals and oxidative stress derived metabolites. Vasilyevich et al measured the activity of glutathione peroxidase (GPX) in cerebrospinal fluid (CSF) of newborn infants with HIE [31]. GPX is an essential component of the glutathione redox enzyme system that reduces superoxide anion into hydrogen peroxide.…”

Section: Discussionmentioning

confidence: 99%

“…An increased activity of GPX indirectly reveals the existence of a pro-oxidant status and oxidative stress. Remarkably, GPX activity in CSF correlated with clinical stage of HIE, CSF concentration of neuron specific enolase a marker of neuronal damage, and with subsequent neurological outcomes revealing that oxidative stress is a decisive agent in the development of HIE [31]. Kumar et al, determined malondialdehyde (MDA) and nitrate/nitrite levels in plasma of 43 term newborn babies who subsequently developed HIE [32].…”

Section: Discussionmentioning

confidence: 99%

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Preliminary case control study to establish the correlation between novel peroxidation biomarkers in cord serum and the severity of hypoxic ischemic encephalopathy

Cháfer-Pericás

Cernada

Rahkonen

et al. 2016

Free Radical Biology and Medicine

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Preliminary case control study to establish the correlation between novel peroxidation biomarkers in cord serum and the severity of hypoxic ischemic encephalopathy

Cháfer-Pericás

Cernada

Rahkonen

et al. 2016

Free Radical Biology and Medicine

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“…Ischemic stroke, which results in insufficient supply of glucose and oxygen to brain tissues, causes significant damage to cells associated with oxidative stress, the regulation of pro-apoptotic and anti-apoptotic factors, and dysfunction of neuronal signaling pathways [1], [2], [3], [4]. The rapid initiation of reperfusion therapy is an effective strategy to reduce the infarct area and minimize the behavioral deficits resulting from ischemia.…”

Section: Introductionmentioning

confidence: 99%

Pretreatment with 2-(4-Methoxyphenyl)ethyl-2-acetamido-2-deoxy-β-D-pyranoside Attenuates Cerebral Ischemia/Reperfusion-Induced Injury In Vitro and In Vivo

et al. 2014

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Salidroside, extracted from the root of Rhodiola rosea L, is known for its pharmacological properties, in particular its neuroprotective effects. 2-(4-Methoxyphenyl) ethyl-2-acetamido-2-deoxy-β-D- pyranoside (GlcNAc-Sal), an analog of salidroside, was recently synthesized and shown to possess neuroprotective properties. The purpose of the current study was to investigate the neuroprotective effects of GlcNAc-Sal against oxygen–glucose deprivation-reperfusion (OGD-R)-induced neurotoxicity in vitro and global cerebral ischemia-reperfusion (GCI-R) injury in vivo. Cell viability tests and Hoechst 33342 staining confirmed that GlcNAc-Sal pretreatment markedly attenuated OGD-R induced apoptotic cell death in immortalized mouse hippocampal HT22 cells. Western blot, immunofluorescence and PCR analyses revealed that GlcNAc-Sal pretreatment restored the balance of pro- and anti-apoptotic proteins and inhibited the activation of caspase-3 and PARP induced by OGD-R treatment. Further analyses showed that GlcNAc-Sal pretreatment antagonized reactive oxygen species (ROS) generation, iNOS-derived NO production and NO-related apoptotic cell death during OGD-R stimulation. GCI-R was induced by bilateral common carotid artery occlusion (BCCAO) and reperfusion in mice in vivo. Western blot analysis showed that GlcNAc-Sal pretreatment decreased the expression of caspase-3 and increased the expression of Bcl-2 (B-cell lymphoma 2)/Bax (Bcl-2-associated X protein) induced by GCI-R treatment. Our findings suggest that GlcNAc-Sal pretreatment prevents brain ischemia reperfusion injury by the direct or indirect suppression of cell apoptosis and GlcNAc-Sal could be developed as a broad-spectrum agent for the prevention and/or treatment of cerebral ischemic injury.

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“…Adanya asidosis yang disertai dengan penurunan glikolisis, hilangnya otoregulasi serebrovaskular, dan penurunan fungsi jantung menyebabkan hipoperfusi otak dan dapat berlanjut menjadi iskemik dari otak. 13,14 Perubahan yang terjadi di SSP akibat iskemik dari otak ini adalah 1) aktivasi glikolisis anaerob, 2) aktivasi enzim protease dan fosfolipase, 3) aktivasi sistem caspase, 4). stres oksidatif dan disfungsi mitokondrial.…”

Section: Pembahasanunclassified

“…14,15 Neuron specific enolase merupakan suatu isoenzim dimerik yang berada dalam sitoplasma sel neuron dan neuroendokrin. 15 Apabila terjadi kerusakan sel neuron tersebut, NSE dapat terdeteksi dalam serum darah.…”

Section: Pembahasanunclassified

Kadar Neuron-Specific Enolase Serum dan Derajat Ensefalopati Hipoksik Iskemik pada Asfiksia Neonatorum

Wijata

Wilar²,

Warouw³

et al. 2016

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Latar belakang. Ensefalopati hipoksik iskemik (EHI) merupakan komplikasi asfiksia neonatorum yang mengenai sistem saraf pusat berupa disfungsi serebrovaskular dan oksigenasi, gangguan neurotransmiter, degenerasi sel-sel neuron, edema serebral yang berakhir pada kematian sel. Penelitian sebelumnya mendapatkan peningkatan kadar neuron specific enolase (NSE) cairan serebrospinal pada bayi dengan EHI. Masih belum banyak penelitian mengenai kadar NSE serum pada bayi dengan EHI. Tujuan. Mengetahui hubungan kadar NSE serum dengan derajat EHI pada asfiksia neonatorum. Metode. Penelitian analitik observasional pendekatan potong lintang dilakukan dari bulan Oktober 2015 sampai Februari 2016. Sampel adalah bayi asfiksia yang mengalami EHI, diambil secara konsekutif. Analisis statistik diuji dengan korelasi Spearman. Orang tua atau wali diminta menandatangani informed consent. Hasil. Kami mendapatkan 39 bayi asfiksia yang mengalami EHI, terdiri atas 20 bayi laki-laki dan 19 perempuan. Terdapat hubungan bermakna antara kadar NSE serum dengan derajat EHI pada asfiksia neonatorum (koefisien korelasi r =0,893 nilai p<0,001). Kesimpulan. Terdapat korelasi positif antara kadar NSE dengan derajat EHI pada asfiksia neonatorum. Sari Pediatri 2016;18(1):1-5Kata kunci: neuron-specific enolase, ensefalopati hipoksik iskemik, asfiksia neonatorum Serum Neuron-Specific Enolase and Hypoxic Ischemic Encephalopathy Degree in Neonatal AsphyxiaAgus Wijata, Rocky Wilar, Sarah M. Warouw, Johnny Rompis Background. Hypoxic ischemic encephalopathy (HIE) is a poor complication of neonatal asphyxia. Previous studies showed elevated levels of cerebrospinal fluid neuron specific enolase (NSE) in infant with HIE. There are very few studies have been conducted about serum NSE level in infant with HIE. Objective. To determine the relationship of serum NSE levels with HIE degree in neonatal asphyxia Method. We conducted an observational study with cross-sectional approach from October 2015 until February 2016. Samples were asphyxiated newborn with HIE based on Sarnat and Sarnat modification criteria. Samples were taken consecutively. The relationship between serum NSE levels with HIE degree were tested with Spearman correlation analysis. Informed consent was attained from parents or guardians. This study was approved by ethical comittee Prof. Dr. R. D. Kandou Hospital Manado. Results. We found 39 asphyxiated newborns with HIE, consisted of 20 boys and 19 girls. There was a significant correlation between serum NSE levels with HIE degree in neonatal asphyxia (correlation coefficient r s =0.893 with p<0.001). Conclusion. The higher levels of serum NSE, the greater degree of HIE in asphyxia neonatorum. Sari Pediatri 2016;18(1):1-5

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The role of oxidative stress in perinatal hypoxic-ischemic brain injury

Abstract: Our results suggest that oxidative stress might be important contributing factor in perinatal hypoxic-ischemic brain damage, particularly in preterm neonates.

Cited by 33 publications

References 24 publications

Preliminary case control study to establish the correlation between novel peroxidation biomarkers in cord serum and the severity of hypoxic ischemic encephalopathy

Preliminary case control study to establish the correlation between novel peroxidation biomarkers in cord serum and the severity of hypoxic ischemic encephalopathy

Pretreatment with 2-(4-Methoxyphenyl)ethyl-2-acetamido-2-deoxy-β-D-pyranoside Attenuates Cerebral Ischemia/Reperfusion-Induced Injury In Vitro and In Vivo

Kadar Neuron-Specific Enolase Serum dan Derajat Ensefalopati Hipoksik Iskemik pada Asfiksia Neonatorum

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