The Role of Oxidative Stress and Inflammatory Mediators in Benign Paroxysmal Positional Vertigo

Abstract

OBJECTIVE:Benign paroxysmal positional vertigo (BPPV) is the most common peripheral cause of vertigo. It can be defined as transient vertigo induced by rapid changes in head position associated with a characteristic paroxysmal positional nystagmus. The aim of this study was to search for the possible role of oxidative stress and inflammatory mediators in the pathogenesis of BPPV. MATERIALS and METHODS:Total antioxidant status as well as paraoxonase, tumor necrosis factor alpha, interleukin (IL) 6, and IL-1β levels were evaluated in peripheral venous serum samples of 30 BPPV and 30 control patients. RESULTS:Total antioxidant status levels were lower in the BPPV group than in the control group (p=0.008). After Epley's repositioning maneuver in the vertigo group, there was a statistically significant decline in IL-1β levels at the first and third month visits (p=0.014 for first month and p=0.013 for third month). CONCLUSION:Our findings suggested that IL-1β and oxidative stress contributed to the pathogenesis of BPPV.

Serum levels of superoxide dismutases in patients with benign paroxysmal positional vertigo

“…Consistent with our findings, Güçlütürk et al [19] confirmed the role of oxidative stress, using native thiol/sulfide (SH/SS) homeostasis as a novel indicator, in the etiology of BPPV. Recent studies have suggested that oxidative stress and inner ear diseases are related.…”

“…The occurrence of inflammatory reaction and oxidative stress may play role in the occurrence of vascular vertigo and BPPV [15,17]. Several prior studies have explored the association between serum oxidative stress markers' concentrations and BPPV [19,28]. To the best of our knowledge, it is the first time to measure serum level of SOD in Chinese patients with BPPV and further assess its association with BPPV recurrence events.…”

“…BPPV includes two types: posterior semicircular canal (PSC) and horizontal semicircular canal (HSC) [17], and canalithiasis of the PSC might be caused in at least 85% of patients [18]. In a recent study, it has been revealed that calcium metabolism and its relationship with oxidative stress might play a role in the development of BPPV [19], while another study suggested a role of oxidative stress in the development of BPPV, through both calcium metabolism and the direct toxic effects of free oxygen radicals, including the triggering of apoptosis [17].…”

Diagnostic Value of Serum Biomarkers for Differentiating Central and Peripheral Causes of Acute Vertigo

“…The serum IL-6 levels in the CV and PV groups were increased compared with the controls. A previous study investigated the roles of oxidative stress and inflammatory mediators in BPPV and vascular vertigo (50,51). The levels of pro-inflammatory mediators, including IL-6, were higher in the BPPV group and decreased with a repositioning maneuver (50).…”

“…A previous study investigated the roles of oxidative stress and inflammatory mediators in BPPV and vascular vertigo (50,51). The levels of pro-inflammatory mediators, including IL-6, were higher in the BPPV group and decreased with a repositioning maneuver (50). The IL-6 levels in vascular vertigo were also significantly higher than those of non-vascular vertigo and controls (51).…”