The role of p53 tumor suppressor gene and bcl-2 protooncogene in rat corpus luteum death

Trott, Edward A.; Plouffe, Leo; Hansen, Keith A.; McDonough, Paul G.; George, Puthenpura; Khan, Iqbal

doi:10.1016/s0002-9378(97)70194-7

Cited by 10 publications

(9 citation statements)

References 21 publications

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“…Prohibitin positive granulosa cells were observed in atretic follicles as well as in the corpus luteum. These observations are consistent with recent reports indicating increased expression of antiproliferative gene products such as p53 which correlate with apoptosis in the atretic follicle (Tilly et al, 1995b) and corpus luteum (Trott et al, 1997). Recently, it was reported that a gonadotropin releasing hormone agonist (GnRH‐Ag) induces luteal apoptosis during early pregnancy (Sridaran et al, 1998) as early as 8 hr after the commencement of in vivo treatment.…”

Section: Resultssupporting

confidence: 93%

“…In 1995, Tilly and colleagues reported that antiproliferative gene products such as p53 are associated with apoptotic follicles. Subsequent studies by Trott et al (1997) also demonstrated that p53 colocalizes with apoptotic cells of the corpus luteum. The present study demonstrates that increases in prohibitin protein levels correlate with the initial events of apoptosis.…”

Section: Discussionmentioning

confidence: 89%

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Immunolocalization and expression of prohibitin, a mitochondrial associated protein within the rat ovaries

et al. 1999

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This study was designed to determine the cellular distribution and pattern of expression for the mitochondria-associated protein, prohibitin, during the transitional stages of follicular differentiation within the rat ovary. Immunohistochemical staining techniques were used on frozen sections to examine the localization of prohibitin to preantral, antral, preovulatory, and atretic follicles. Prohibitin localization was also determined in corpus luteum from adult rats, in addition to those from infant and juvenile ovaries, before and after gonadotropin stimulation. Western and Northern blotting techniques were used for qualitative and quantitative assessment of prohibitin expression levels within the ovary. Prohibitin was localized within granulosa cells of infant and juvenile ovaries in a relatively heterogeneous staining pattern. The oocyte also exhibited robust prohibitin expression at all stages of follicular development. In addition, strong prohibitin expression was evident in the corpus luteum as well as in follicles undergoing atresia. Additional data derived from studies involving a GnRH-agonist indicate that increases in prohibitin protein expression correlate with the initial events of apoptosis. Collectively, these results support a growth regulatory role for prohibitin within the rat ovary. Therefore, we propose that prohibitin may serve as an important regulator of granulosa cell fate during follicular development.

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Section: Resultssupporting

confidence: 93%

Section: Discussionmentioning

confidence: 89%

Immunolocalization and expression of prohibitin, a mitochondrial associated protein within the rat ovaries

et al. 1999

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“…It remains unclear whether increases in bax mRNA are p53 mediated. Levels of mRNA encoding p53 do not increase during luteolysis (313,366); however, p53 activity may be regulated primarily at the posttranslational level (398).…”

Section: H Apoptosismentioning

confidence: 96%

Mechanisms Controlling the Function and Life Span of the Corpus Luteum

Niswender

Juengel

Silva

et al. 2000

Physiological Reviews

865

553

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The primary function of the corpus luteum is secretion of the hormone progesterone, which is required for maintenance of normal pregnancy in mammals. The corpus luteum develops from residual follicular granulosal and thecal cells after ovulation. Luteinizing hormone (LH) from the anterior pituitary is important for normal development and function of the corpus luteum in most mammals, although growth hormone, prolactin, and estradiol also play a role in several species. The mature corpus luteum is composed of at least two steroidogenic cell types based on morphological and biochemical criteria and on the follicular source of origin. Small luteal cells appear to be of thecal cell origin and respond to LH with increased secretion of progesterone. LH directly stimulates the secretion of progesterone from small luteal cells via activation of the protein kinase A second messenger pathway. Large luteal cells are of granulosal cell origin and contain receptors for PGF(2alpha) and appear to mediate the luteolytic actions of this hormone. If pregnancy does not occur, the corpus luteum must regress to allow follicular growth and ovulation and the reproductive cycle begins again. Luteal regression is initiated by PGF(2alpha) of uterine origin in most subprimate species. The role played by PGF(2alpha) in primates remains controversial. In primates, if PGF(2alpha) plays a role in luteolysis, it appears to be of ovarian origin. The antisteroidogenic effects of PGF(2alpha) appear to be mediated by the protein kinase C second messenger pathway, whereas loss of luteal cells appears to follow an influx of calcium, activation of endonucleases, and an apoptotic form of cell death. If the female becomes pregnant, continued secretion of progesterone from the corpus luteum is required to provide an appropriate uterine environment for maintenance of pregnancy. The mechanisms whereby the pregnant uterus signals the corpus luteum that a conceptus is present varies from secretion of a chorionic gonadotropin (primates and equids), to secretion of an antiluteolytic factor (domestic ruminants), and to a neuroendocrine reflex arc that modifies the secretory patterns of hormones from the anterior pituitary (most rodents).

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“…Based on these data, Beumer et al proposed that p53 was an important factor in normal spermatogonial cell proliferation as well as in the regulation of apoptosis after DNA damage (Beumer et al, 1998). In females, p53 was detected in granulosa cells in the follicles and luteal cells in the corpus luteum of the ovary (Trott et al, 1997;Makrigiannakis et al, 2000). In large antral and preovulatory follicles occurring atresia, expression of p53 and Fas was increased, suggesting involvement of p53 as well as Fas in this process (Kim et al, 1999).…”

Section: P53mentioning

confidence: 99%

Physiological and Pathological Cell Deaths in the Reproductive Organs.

Sakamaki

2003

Cell Struct. Funct.

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Apoptosis of testicular germ cells and oocytes and their supporting cells in the gonads occurs at physiological and normal conditions or after exposure to pathological stimuli. Cell-death regulators, including Bcl-2 family members, caspases, Fas and p53 are thought to be involved in these processes. This article reviews the details of the apoptotic machinery in the reproductive organs by describing briefly the abnormal phenotypes observed in transgenic and gene-ablated mice.

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The role of p53 tumor suppressor gene and bcl-2 protooncogene in rat corpus luteum death

Cited by 10 publications

References 21 publications

Immunolocalization and expression of prohibitin, a mitochondrial associated protein within the rat ovaries

Immunolocalization and expression of prohibitin, a mitochondrial associated protein within the rat ovaries

Mechanisms Controlling the Function and Life Span of the Corpus Luteum

Physiological and Pathological Cell Deaths in the Reproductive Organs.

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