The role of pH on the preparation of citric acid coated cobalt ferrite nanoparticles for biomedical applications

Nagy, Ľuboš; Zeleňáková, A.; Hrubovčák, Pavol; Barutiak, Michael; Lisnichuk, Maksym; Bednarčı́k, J.; Vargová, Jana; Jendželovský, Rastislav; Ševc, Juraj; Vilček, Štefan

doi:10.1016/j.jallcom.2023.170833

Cited by 8 publications

(1 citation statement)

References 45 publications

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“…Citric acid (CA) possesses the capacity to act as a stabilizer to prevent the agglomeration of particles and enhance the dispersion of nanoparticles within a solution. The ZnF NPs underwent surface modification through the direct addition of CA, resulting in the formation of modified ZnF NPs containing carboxylic groups 52 . In this experiment, ZnF NPs were combined with CA solution in water (0.02 g/ml) at a temperature of 60 °C.…”

Section: Methodsmentioning

confidence: 99%

Immobilized lipase enzyme on green synthesized magnetic nanoparticles using Psidium guava leaves for dye degradation and antimicrobial activities

Fahim,

El-Khawaga,

Sallam

et al. 2024

Sci Rep

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Zinc ferrite nanoparticles (ZnF NPs) were synthesized by a green method using Psidium guava Leaves extract and characterized via structural and optical properties. The surface of ZnF NPs was stabilized with citric acid (CA) by a direct addition method to obtain (ZnF-CA NPs), and then lipase (LP) enzyme was immobilized on ZnF-CA NPs to obtain a modified ZnF-CA-LP nanocomposite (NCs). The prepared sample’s photocatalytic activity against Methylene blue dye (MB) was determined. The antioxidant activity of ZnF-CA-LP NCs was measured using 1,1-diphenyl-2-picryl hydrazyl (DPPH) as a source of free radicals. In addition, the antibacterial and antibiofilm capabilities of these substances were investigated by testing them against gram-positive Staphylococcus aureus (S. aureus ATCC 25923) and gram-negative Escherichia coli (E. coli ATCC 25922) bacterial strains. The synthesized ZnF NPs were discovered to be situated at the core of the material, as determined by XRD, HRTEM, and SEM investigations, while the CA and lipase enzymes were coated in this core. The ZnF-CA-LP NCs crystallite size was around 35.0 nm at the (311) plane. Results obtained suggested that 0.01 g of ZnF-CA-LP NCs achieved 96.0% removal of 5.0 ppm of MB at pH 9.0. In-vitro zone of inhibition (ZOI) and minimum inhibitory concentration (MIC) results verified that ZnF-CA-LP NCs exhibited its encouraged antimicrobial activity against S. aureus and E. coli (20.0 ± 0.512, and 27.0 ± 0.651 mm ZOI, respectively) & (1.25, and 0.625 μg/ml MIC, respectively). ZnF-CA-LP NPs showed antibiofilm percentage against S. aureus (88.4%) and E. coli (96.6%). Hence, ZnF-CA-LP NCs are promising for potential applications in environmental and biomedical uses.

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Section: Methodsmentioning

confidence: 99%

Immobilized lipase enzyme on green synthesized magnetic nanoparticles using Psidium guava leaves for dye degradation and antimicrobial activities

Fahim,

El-Khawaga,

Sallam

et al. 2024

Sci Rep

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Fabrication of a Nanomagnetic Smart Polymer Carrier as a Potential Candidate for a Drug Delivery System

Jafarzadeh,

Peyman,

Roshanfekr

et al. 2024

Arab J Sci Eng

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We developed an intelligent device capable of controlled release of anti-cancer drugs. The nano-carrier consists of two key components: firstly, magnetic nanoparticles were synthesized through co-precipitation and then functionalized for attaching anti-cancer drugs; secondly, a polymer (poly(N-isopropylacrylamide-co-acrylic acid)) sensitive to pH and temperature was synthesized and employed to encapsulate the drug-loaded magnetic nanoparticles. This responsive polymer exhibits a lower critical solution temperature (LCST) of 38.5 °C, indicating a phase transition behavior. Numerous techniques and analyses, including Fourier transform infrared spectroscopy, thermogravimetric analysis, zeta potentials, scanning electron microscope, and transmission electron microscopy, were employed to confirm the successful execution of the aforementioned process. In vitro release assessments of the anti-cancer drug, doxorubicin, were conducted across various media (pH 5–8 and temperatures ranging from 20 to 40 °C). The outcomes revealed higher drug releases at temperatures exceeding the LCST (40 °C) and at slightly acidic pH levels (5–5.3). Notably, compared to the effectiveness of the unloaded drug, the magnetic smart polymer loaded with DOX exhibited a more potent cytotoxic effect. Considering these results, this nano-carrier emerges as a promising candidate for targeted therapeutic delivery to cancerous tissues.

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Nickel films deposited between amorphous silicon layers: Effects of annealing, Ni/Si interface and magnetic properties

Tadić,

Panjan,

Kovač

et al. 2025

Applied Surface Science

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The role of pH on the preparation of citric acid coated cobalt ferrite nanoparticles for biomedical applications

Cited by 8 publications

References 45 publications

Immobilized lipase enzyme on green synthesized magnetic nanoparticles using Psidium guava leaves for dye degradation and antimicrobial activities

Immobilized lipase enzyme on green synthesized magnetic nanoparticles using Psidium guava leaves for dye degradation and antimicrobial activities

Fabrication of a Nanomagnetic Smart Polymer Carrier as a Potential Candidate for a Drug Delivery System

Nickel films deposited between amorphous silicon layers: Effects of annealing, Ni/Si interface and magnetic properties

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