The Role of Phenolic Compounds in the Fight against Cancer – A Review

Carocho, Márcio; Ferreira, Isabel C.F.R.

doi:10.2174/18715206113139990301

Cited by 237 publications

(154 citation statements)

References 202 publications

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“…Several studies have been conducted to evidence the bioactive properties of mushroom extracts as well as of their secondary metabolites such as antioxidant (Ferreira, Barros, & Abreu, 2009;Heleno, Martins, Queiroz, & Ferreira, 2015;Puttaraju, Venkateshaiah, Dharmesh, Urs, &Somasundaram, 2006), antitumor (Carocho & Ferreira, 2013;Ferreira, Vaz, Vasconcelos, & Martins, 2010;Moradali, Mostafavi, Ghods, & Hedjaroude, 2007),…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory potential of mushroom extracts and isolated metabolites

Taofiq

Martins

Barreiro

et al. 2016

Trends in Food Science & Technology

108

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Background: In the recent years natural resources are being in focus due to their great potential to be exploited in the discovery/development of novel bioactive compounds and, among them, mushrooms can be highlighted as alternative sources of anti-inflammatory agents. Scope and approach:The present review reports the anti-inflammatory activity of mushroom extracts and of their bioactive metabolites involved in this bioactive action.Additionally the most common assays used to evaluate mushrooms anti-inflammatory activity were also reviewed, including in vitro studies in cell lines, as well as in animal models in vivo. Key findings and conclusions:The anti-inflammatory compounds identified in mushrooms include polysaccharides, terpenes, phenolic acids, steroids, fatty acids and other metabolites.Among them, polysaccharides, terpenoids and phenolic compounds seem to be the most important contributors to the anti-inflammatory activity of mushrooms as demonstrated by numerous studies. However, clinical trials need to be conducted in order to confirm the effectiveness of some of these mushroom compounds namely, inhibitors of NF-κB pathway and of cyclooxygenase related with the expression of many inflammatory mediators.

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Section: Introductionmentioning

confidence: 99%

Anti-inflammatory potential of mushroom extracts and isolated metabolites

Taofiq

Martins

Barreiro

et al. 2016

Trends in Food Science & Technology

108

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“…11,12 Furthermore, antitumor properties have also been attributed to different phenolic compounds, including avones. 13 Other important antioxidant molecules are tocopherols, which are considered as one of the most important antioxidants to combat oxidative stress, because they inhibit the production of peroxyl radicals, protecting cells of oxidative damage to low density lipoproteins, proteins and DNA, and of membrane degeneration due to peroxidation of polyunsaturated fatty acids. 14,15 Some organic acids are also excellent antioxidants; for example, ascorbic acid, being a potent reducing agent, has the capacity to reduce the most reactive species of oxygen and nitrogen protecting against lipid peroxidation.…”

Section: Introductionmentioning

confidence: 99%

Bioactivity and phytochemical characterization of Arenaria montana L.

et al. 2014

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The bioactivity (antioxidant and cytotoxic activities) of the aqueous and methanolic extracts of Arenaria montana L., a plant commonly used in Portuguese folk medicine, was evaluated and compared.Furthermore, the phytochemical composition was determined based on hydrophilic (sugars, organic acids and phenolic compounds) and lipophilic (fatty acids and tocopherols) compounds, in order to valorize this plant material as a functional food/nutraceutical. Fructose, oxalic acid, methyl-luteolin 2 00 -O-feruloylhexosyl-C-hexoside, a-tocopherol, and linoleic acid were the main individual compounds found in A. montana. In general, the aqueous extract showed higher antioxidant and cytotoxic activities than the methanolic extract; the latter showed activity only against HeLa and HepG2 cell lines. Both aqueous and methanolic extracts showed some hepatotoxicity but at higher doses than the ones active for tumor cell lines. Moreover, the aqueous extract of A. montana may be used as a functional food or nutraceutical due to the high antioxidant and cytotoxic activities, and due to the presence of bioactive compounds. As far as we know, this is the first report on the phytochemical composition and bioactivity of A. montana.

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“…Of these compounds, many come from the secondary metabolism of plants, like terpenes, alcaloids and phenolic compounds. There are many effects that these compounds display towards tumours; namely the complete inhibition of growth, apoptosis induction, suppression of the secretion of matrix metalloproteinases and reduction of tumor invasive behavior (Carocho and Ferreira, 2013). The same issue occurs in the search for antimicrobial drugs, with resistance to antibiotics and antifungals rising in recent years along with a decrease in the supply of new drugs for these microorganisms.…”

Section: Introductionmentioning

confidence: 99%

Infusions and decoctions of Castanea sativa flowers as effective antitumor and antimicrobial matrices

Carocho

Calhelha

Queiroz

et al. 2014

Industrial Crops and Products

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Chestnut trees are one of the most important crops in the North-eastern part of Portugal, representing millions of euros of yearly income. There are many ancestral claims of the health benefits of the consumption of chestnut flowers in infusions that remain unproven. In this manuscript, the antitumor and antimicrobial potential of chestnut flowers from two cultivars, Judia and Longal, extracted through infusions and decoctions are reported. In terms of antitumor activity, the most sensitive cell lines were HepG2 and HCT15 with the cultivar Judia showing higher activity for HCT15 and Longal for HepG2, regardless of the extraction methods. Regarding the antibacterial activity of the extracts, decoctions proved to be more effective with lower minimum inhibition concentrations, while infusions were better in terms of antifungal activity.The good overall antimicrobial activity could justify the inclusion of the flowers in food chain processing to act as a natural antimicrobial. Furthermore, the results corroborate some of the ancestral claims of the consumption of these flowers.

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The Role of Phenolic Compounds in the Fight against Cancer – A Review

Cited by 237 publications

References 202 publications

Anti-inflammatory potential of mushroom extracts and isolated metabolites

Anti-inflammatory potential of mushroom extracts and isolated metabolites

Bioactivity and phytochemical characterization of Arenaria montana L.

Infusions and decoctions of Castanea sativa flowers as effective antitumor and antimicrobial matrices

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