The Role of Pioglitazone Against Ehrlich Solid Carcinoma Mice Model Through Antiproliferative and Antiangiogenic Pathways

Abstract

C ancer is the second prominent cause of death globally, also prevalence is expected to increase by 2040 due to the increase in the new cases of malignancy annually (Bray et al., 2018). Chemotherapeutic medications are extensively used in cancer treatment either alone or with radiotherapy and surgical interventions. Cisplatin, one of the antineoplastic alkylating agents, has a significant proven efficacy against many types of malignancies, such as the neck, ovaries, testes, and lung cancers (Al-Eitan et al., 2020). However, despite its substantial antineoplastic