The Role of Platelet Plasma Growth Factors in Male Pattern Baldness Surgery

Uebel, Carlos Oscar; Silva, Jefferson Braga da; Cantarelli, D; Martins, Pedro Djacir Escobar

doi:10.1097/01.prs.0000239560.29172.33

Cited by 264 publications

(211 citation statements)

References 22 publications

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“…The significant correlations were seen between these two populations abnormally. These abnormal correlations can leads to abnormalities like AGA [26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Androgenetic Alopecia: A Chronic or Pubertal Onset Disease Retarded by Blood Donation

Dayer

Dehghani

Daer³

et al. 2017

Zahedan J Res Med Sci

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Background: Androgenetic alopecia is the main cause of hair loss and common baldness that affects psychological more than physiological aspects of people's lives. Studies have shown that this multi factorial disorder is initiated by androgens secretion in pubertal period, minerals limitations, autoimmunity, mental stress, genetic predisposition and some alterations in hematological factors. Objectives: The aim of this study was to evaluate the involvement of hematologic parameters in this disease using a case control study design. Methods: In this case-controlled study, two groups each of 80 individuals with androgenetic alopecia were voluntarily included in the study based on their medical histories and clinical examinations and subjected to blood tests for routine hematological parameters. The results were then compared and analyzed using SPSS version 16.0.

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“…The significant correlations were seen between these two populations abnormally. These abnormal correlations can leads to abnormalities like AGA [26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Androgenetic Alopecia: A Chronic or Pubertal Onset Disease Retarded by Blood Donation

Dayer

Dehghani

Daer³

et al. 2017

Zahedan J Res Med Sci

View full text Add to dashboard Cite

show abstract

“…[8,10] It also appears to increase the perifollicular vascular plexus through the increase of VEGF and PDGF levels, which have angiogenic potential. [11] Uebel et al [5] showed that pretreatment of follicular units with PRP before transplantation resulted in improved hair growth and density. The positive effect of PRP in the treatment of AGA has been documented in other studies.…”

Section: Discussionmentioning

confidence: 99%

“…[4] It is hypothesised these growth factors may act on stem cells in the bulge area of the follicles, stimulating the development of new follicles and promoting neo-vascularisation. [5] Skin needling is a technique that uses a sterile dermaroller to puncture the skin and release growth factors. Hence, PRP can be combined with skin needling to enhance the efficacy of both modalities.…”

Section: Introductionmentioning

confidence: 99%

A study of the efficacy of skin needling and platelet rich plasma in the treatment of androgenetic alopecia

Ranjan¹,

Gupta²,

Gupta³

2017

APJHS

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Background: Platelet-rich plasma (PRP) is an autologous preparation of platelets in concentrated plasma that may be useful in the treatment of androgenetic alopecia (AGA). Its action depends on the released growth factors from platelets. Skin needling is a technique that uses a sterile dermaroller to puncture the skin and release growth factors. The combination of Skin needling and PRP should enhance the efficacy of both modalities. Objective: To establish the effectiveness of the combined use of Skin needling and PRP in AGA treatment. Method: The study enrolled 10 patients of AGA. The hair pull test was performed before each treatment session. PRP therapy with skin needling was given to them at monthly intervals for 6 months. The effects of therapy were evaluated based on clinical examination, hair pull test, photographic assessment and patient's satisfaction. Result: Before treatment, 80 % of our patients had a positive hair pull test with a mean number of 9 hairs which turned to be negative only after the third session. After 6 months, there was an overall improvement in hair density with the response of grade +2 in 8 patients and +1 in 2 patients on the standardised 7-point evaluation scale. 3 patients rated response as grade 4, 5 patients as grade 3 and 2 patients as grade 2 on patients' subjective evaluation of hair growth. Pain during the procedure and sensible scalp afterwards were the major complaints which subsided in 2-3 days. Conclusion: PRP combined with skin needling is a safe and effective treatment and can be considered as an alternative for management of AGA.

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“…Uebel et al [13] observed a significant improvement in hair density and stimulation of growth when follicular units were pre-treated with platelet plasma growth factors before their implantation. There was a significant difference in the yield of follicular units on comparing the experimental with the control areas of the scalp.…”

Section: Vascular Endothelial Growth Factor Regulation Of Angiogenesismentioning

confidence: 99%

Efficacy of Platelet Rich Plasma in Treatment of Androgenic Alopecia

Dhot¹

2016

HTIJ

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Background: Platelet-rich plasma (PRP) has shown remarkable beneficial effects without any major adverse reactions in the treatment of androgenic alopecia .The growth factors in activated autologous PRP induces the proliferation of dermal papilla cells. Objectives:To investigate the clinical efficacy of Platelet Rich Plasma in treatment of androgenic alopecia.Methods: Ten patients were given autologous PRP injections on the affected area of alopecia over a period of three months at interval of two -three weeks and results were assessed.Results: Three months after the treatment, the patients presented clinical improvement in the hair counts, hair thickness, hair root strength and overall alopecia.Conclusion: PRP appears to be a cheap, effective and promising therapy for androgenic alopecia with no major adverse effects.

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The Role of Platelet Plasma Growth Factors in Male Pattern Baldness Surgery

Cited by 264 publications

References 22 publications

Androgenetic Alopecia: A Chronic or Pubertal Onset Disease Retarded by Blood Donation

Androgenetic Alopecia: A Chronic or Pubertal Onset Disease Retarded by Blood Donation

A study of the efficacy of skin needling and platelet rich plasma in the treatment of androgenetic alopecia

Efficacy of Platelet Rich Plasma in Treatment of Androgenic Alopecia

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