The Role of Platelet-Rich Plasma in Cartilage Pathology: An Updated Systematic Review of the Basic Science Evidence

Fice, Michael P.; Miller, J. Chance; Christian, Robert A.; Hannon, Charles P.; Smyth, Niall A.; Murawski, Christopher D.; Cole, Brian J.; Kennedy, John G.

doi:10.1016/j.arthro.2018.10.125

Cited by 74 publications

(54 citation statements)

References 46 publications

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“…At least 21 different PRP production devices are currently available and are applied without standardization (Gato-Calvo et al, 2019;Oudelaar et al, 2019). Studies often report limited characterization of the contents of PRP (Fice et al, 2019). Additionally, donor variability impacts not only the cell profiles of the final product, but also secretory components such as growth factors (Mazzocca et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Characterization and Chondroprotective Effects of Extracellular Vesicles From Plasma- and Serum-Based Autologous Blood-Derived Products for Osteoarthritis Therapy

Otahal

Kramer

Kuten

et al. 2020

Front. Bioeng. Biotechnol.

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Autologous blood products gain increasing interest in the field of regenerative medicine as well as in orthopedics, aesthetic surgery, and cosmetics. Currently, citrate-anticoagulated platelet-rich plasma (CPRP) preparations are often applied in osteoarthritis (OA), but more physiological and cell-free alternatives such as hyperacute serum (hypACT) are under development. Besides growth factors, blood products also bring along extracellular vesicles (EVs) packed with signal molecules, which open up a new level of complexity at evaluating the functional spectrum of blood products. Large proportions of EVs originated from platelets in CPRP and hypACT, whereas very low erythrocyte and monocyte-derived EVs were detected via flow cytometry. EV treatment of chondrocytes enhanced the expression of anabolic markers type II collagen, SRY-box transcription factor 9 (SOX9), and aggrecan compared to full blood products, but also the catabolic marker and tissue remodeling factor matrix metalloproteinase 3, whereas hypACT EVs prevented type I collagen expression. CPRP blood product increased SOX9 protein expression, in contrast to hypACT blood product. However, hypACT EVs induced SOX9 protein expression while preventing interleukin-6 secretion. The results indicate that blood EVs are sufficient to induce chondrogenic gene expression changes in OA chondrocytes, while preventing proinflammatory cytokine release compared to full blood product. This highlights the potential of autologous blood-derived EVs as regulators of cartilage extracellular matrix metabolism and inflammation, as well as candidates for new cell-free therapeutic approaches for OA.

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Section: Introductionmentioning

confidence: 99%

Characterization and Chondroprotective Effects of Extracellular Vesicles From Plasma- and Serum-Based Autologous Blood-Derived Products for Osteoarthritis Therapy

Otahal

Kramer

Kuten

et al. 2020

Front. Bioeng. Biotechnol.

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“…PRP has demonstrated its biological effect over the chondrocytes of articular cartilage and its consequent impact on cartilage repair. Fice et al published a systematic review including numerous in vitro and in vivo studies that showed the action of PRP on the cellular response [70]. On the one hand, it acts on cellular behavior, increasing growth, migration, and proliferation rates and reducing negative effects such as apoptosis.…”

Section: Cellular Modulating Effectmentioning

confidence: 99%

Isolation, Activation, and Mechanism of Action of Platelet-Rich Plasma and Its Applications for Joint Repair

Sánchez¹,

Beitia²,

Pompei³

et al. 2020

Regenerative Medicine

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Platelet-Rich Plasma (PRP) is a biologic therapy that uses the patient's own blood to obtain products with a higher platelet concentration than in blood. This technology provides a controlled drug delivery system of growth factors suitable for regenerative medicine. The biological effects of PRP mimic and influence biological processes such as inflammation, analgesia, and cell stimulation, providing this therapy with promising therapeutic potential. All these processes participate in maintenance, correct function, and homeostasis of the joint, where all tissues are involved. Alterations in one joint element have impact on the rest, outstanding the cellular and molecular interaction between the cartilage and subchondral bone. Therefore, the joint is an optimal therapeutic target for PRP therapy, which favors biological environment for joint repair. This chapter collects the basic concepts of joint function and the biological processes that participate in its degeneration, the definition and obtention of PRP, as well as its therapeutic potential and clinical translation.

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“…As with many in vitro studies evaluating the effect of PRP on cartilage, 5 the translatability of the results of Titan et al 4 may be limited by several factors: the small size of the lesions, use of several human blood donors, lack of a biomechanical evaluation of axial compressive or horizontal shearing forces, and more. Nevertheless, this study is unique in terms of the rigorous methodology used, and its outcomes suggest that HA scaffolds augmented with L-PRP or L-PRF may play a role in Tel Aviv, Israel (R.G.)…”

Section: See Related Article On Page 1431mentioning

confidence: 99%

Editorial Commentary: Orthobiologics—The Evolution From Symptom to Structural Modification in the Treatment of Articular Cartilage Defects

Gilat¹,

Cole²

2020

Arthroscopy: The Journal of Arthroscopic & Related Surgery

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The race is on to identify the optimal recipe for the treatment of focal cartilage defects. Although many attempts had been made, beyond the use of osteochondral allografts, the restoration of pristine hyaline cartilage still seems distant and out of reach. The fundamental assumption is that cartilage restoration constructs must provide both structural integrity and adequate biological features that provide the optimal environment for hyaline cartilage formation. Augmentation of biologic scaffolds and grafts with orthobiologic agents may attend to both needs by improving defect fill and integration to the host articular cartilage interface.

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The Role of Platelet-Rich Plasma in Cartilage Pathology: An Updated Systematic Review of the Basic Science Evidence

Cited by 74 publications

References 46 publications

Characterization and Chondroprotective Effects of Extracellular Vesicles From Plasma- and Serum-Based Autologous Blood-Derived Products for Osteoarthritis Therapy

Characterization and Chondroprotective Effects of Extracellular Vesicles From Plasma- and Serum-Based Autologous Blood-Derived Products for Osteoarthritis Therapy

Isolation, Activation, and Mechanism of Action of Platelet-Rich Plasma and Its Applications for Joint Repair

Editorial Commentary: Orthobiologics—The Evolution From Symptom to Structural Modification in the Treatment of Articular Cartilage Defects

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