The role of platelets in the pathogenesis of systemic sclerosis

Ramirez, Giuseppe A.; Franchini, Stefano; Rovere‐Querini, Patrizia; Sabbadini, Maria Grazia; Manfredi, Angelo A.; Maugeri, Norma

doi:10.3389/fimmu.2012.00160

Cited by 38 publications

(33 citation statements)

References 57 publications

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“…Recently PTX3 has been detected in various chronic inflammatory conditions, like atherosclerosis [58], and is recognized as an early marker for unstable angina [59] and myocardial infarction [60]. It was found that it is released by the endothelium and by activated myofibroblasts in systemic sclerosis [61]. It was suggested that PTX3 may contribute to the pathogene-sis of atherosclerosis [59], and hence thrombo-embolic events leading to CVDs and CKDs.…”

Section: Functions Of Crpmentioning

confidence: 99%

Pentraxins as Key Disease Markers for Periodontal Diagnosis

et al. 2013

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Periodontal diseases are characterized by a complex set of biologic interactions between a diverse and dynamic microbial ecosystem and the host’s multifaceted and responsive immune and inflammatory machinery. Such interactions between microbial pathogens and various host response systems play a critical role in the development and progression of periodontal disease via the release of inflammatory and immune mediators. Advances in periodontal disease diagnostic are moving toward methods whereby periodontal risk can be identified and quantified by detecting such inflammatory mediators in its sequential pathophysiology. Pentraxins (PTXs) are classical mediators of inflammation and markers of acute-phase reaction. They are a super family of multifunctional molecules characterized by multimeric structure, divided into “short” PTXs and “long” PTXs. C-reactive protein (CRP) and pentraxin-3 (PTX3) are prototypic molecules of the short and long PTX family, respectively. Evidence suggests that PTXs acts as a non-redundant component of the humoral arm of innate immunity, downstream of, and complementary to, cellular recognition, as well as a tuner of inflammation. CRP is a cheaper biomarker and more readily available in everyday clinical practice compared with other inflammatory markers, on the other hand, PTX3 is believed to be the true independent indicator of disease activity and could have clinical implication in diagnosing the “at site” inflammatory status of the periodontal disease. These pentraxins are sensitive and specific in the diagnosis and prognosis of chronic diseases. Thus the pentraxins could be used as preferred biomarkers in periodontal disease diagnosis.

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Section: Functions Of Crpmentioning

confidence: 99%

Pentraxins as Key Disease Markers for Periodontal Diagnosis

et al. 2013

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“…Concomitant to the changes in the SSc endothelial lining, platelets undergo activation (19)(20)(21) and release vascular endothelial growth factor, platelet-derived growth factor, transforming growth factor-, and serotonin (15). Platelets are also a source of the high-mobility group box 1 (HMGB1) protein (22), a damage-associated molecular pattern (DAMP) (23)(24)(25)(26)(27).…”

Section: Introductionmentioning

confidence: 99%

Platelet microparticles sustain autophagy-associated activation of neutrophils in systemic sclerosis

et al. 2018

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Endothelial cell damage and platelet activation contribute to sustained vasculopathy, which is a key clinical characteristic of systemic sclerosis (SSc), also known as scleroderma. Microparticles released from activated platelets in the blood of SSc patients (SSc-microparticles) are abundant and express the damage-associated molecular pattern (DAMP) HMGB1. SSc-microparticles interacted with neutrophils in vitro and in immunocompromised mice and promoted neutrophil autophagy, which was characterized by mobilization of their granule content, enhanced proteolytic activity, prolonged survival, and generation of neutrophil extracellular traps (NETs). Neutrophils migrated within the mouse lung, with collagen accumulation in the interstitial space and the release of soluble E-selectin by the vascular endothelium. Microparticle-neutrophil interaction, neutrophil autophagy and survival, and generation of NETs abated in the presence of BoxA, a competitive inhibitor of HMGB1. Consistent with these results, neutrophils in the blood of SSc patients were autophagic and NET by-products were abundant. Our findings implicate neutrophils in SSc vasculopathy and suggest that platelet-derived, microparticle-associated HMGB1 may be a potential indicator of disease and target for novel therapeutics.

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“…30,35,38,61,101 A higher fraction of neutrophils expressing tissue factor has been observed particularly in patients with giant cell arteritis 36,44 and systemic sclerosis. 45,51,102 In these patients, the pharmacological treatment or the disease duration was apparently irrelevant, while the extent of the tissue factor expression on the neutrophil surface was associated with the fraction of activated platelets as well as with the formation of platelet-neutrophil heterotypic aggregates.…”

Section: Tissue Factor Expression By Neutrophils In Autoimmune Diseasesmentioning

confidence: 96%

Tissue Factor Expressed by Neutrophils: Another Piece in the Vascular Inflammation Puzzle

Maugeri

Manfredi

2015

Semin Thromb Hemost

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The transition from the classic role of neutrophils as the first line of defense of the immune system to that of physiological regulators of intravascular thrombosis took nearly three decades to emerge. This transition needed time to unravel the complex links between the mechanisms that regulate hemostasis and inflammation and the innate immune response, multicellular and multifactorial processes that interact with each other. The present review is focused on the expression of tissue factor by neutrophils, a critical event in their inflammatory and thrombotic function.

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The role of platelets in the pathogenesis of systemic sclerosis

Cited by 38 publications

References 57 publications

Pentraxins as Key Disease Markers for Periodontal Diagnosis

Pentraxins as Key Disease Markers for Periodontal Diagnosis

Platelet microparticles sustain autophagy-associated activation of neutrophils in systemic sclerosis

Tissue Factor Expressed by Neutrophils: Another Piece in the Vascular Inflammation Puzzle

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