2013
DOI: 10.1158/0008-5472.can-13-2197
|View full text |Cite
|
Sign up to set email alerts
|

The Role of Polo-like Kinase 1 in Carcinogenesis: Cause or Consequence?

Abstract: Polo-like kinase 1 (Plk1) is a well-established mitotic regulator with a diverse range of biological functions continually being identified throughout the cell cycle. Pre-clinical evidence suggests that the molecular targeting of Plk1 could be an effective therapeutic strategy in a wide range of cancers, however, that success has yet to be translated to the clinical level. The lack of clinical success has raised the question of whether there is a true oncogenic addiction to Plk1 or if its overexpression in tum… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

4
126
0

Year Published

2015
2015
2024
2024

Publication Types

Select...
10

Relationship

0
10

Authors

Journals

citations
Cited by 115 publications
(130 citation statements)
references
References 105 publications
4
126
0
Order By: Relevance
“…The accumulation of mutations during tumorigenesis likely requires several events of checkpoint recovery. Consistent with this is the finding that positive regulators of checkpoint recovery in G2 are commonly overexpressed in cancer and associated with poor prognosis (Bulavin et al, 2002;Cholewa et al, 2013;Li et al, 2002;Wang et al, 2008;Wierstra, 2013). Conversely, tumorigenesis is impaired in their absence (Bulavin et al, 2004;Wang et al, 2009), and several regulators of G2 checkpoint recovery are under (pre)clinical evaluation (Gilmartin et al, 2014;Gumireddy et al, 2005;Stadler et al, 2014).…”
Section: Discussionmentioning
confidence: 83%
“…The accumulation of mutations during tumorigenesis likely requires several events of checkpoint recovery. Consistent with this is the finding that positive regulators of checkpoint recovery in G2 are commonly overexpressed in cancer and associated with poor prognosis (Bulavin et al, 2002;Cholewa et al, 2013;Li et al, 2002;Wang et al, 2008;Wierstra, 2013). Conversely, tumorigenesis is impaired in their absence (Bulavin et al, 2004;Wang et al, 2009), and several regulators of G2 checkpoint recovery are under (pre)clinical evaluation (Gilmartin et al, 2014;Gumireddy et al, 2005;Stadler et al, 2014).…”
Section: Discussionmentioning
confidence: 83%
“…Paradoxically, some literature show loss of PLK1 is also associated with tumor formation (27,28). PLK1 homozygous-null mice were embryonic lethal, and early PLK1 (À/À) embryos failed to survive after the eight-cell stage.…”
Section: Introductionmentioning
confidence: 99%
“…Overexpression of PLK1 is linked to poor prognosis in a variety of different cancers (26,27). In contrast to healthy cells, it localizes to the nucleus already before G 2 -M in cancer cells and can be detected during the entire interphase (28). Therefore, cancer cell-specific functions in G 1 -S transition and DNA replication are suggested beyond its role in regulation of mitosis.…”
Section: Introductionmentioning
confidence: 99%