The Role of Polyhexamethylene Biguanide and Silver Nanoparticle Interaction in the Fabrication of Novel Antibacterial Bio-Fibers Using Silk Wastage

Abstract

Regenerated silk fibers were fabricated through dry-wet spinning process using N-methyl morpholine N-oxide and methanol as solvent and coagulant, respectively. Several concentrations of polyhexamethylene biguanide (PHMB) (0.5, 0.75 and 1% (v/v)) and silver nanoparticles (AgNPs) (5, 15, 55, 95 and 135 ppm) were used as antibacterial agents. Antibacterial property of bio-fibers produced by either master batch or dipping process methods was compared to each other against a gram-positive bacterium, Staphylococcus aurous. Master batch process was indicated the dependency of antibacterial effect on the concentration of antibacterial agents as well as particle size. Maximum bactericidal activity in this process was obtained at concentrations of 55 ppm of AgNPs and 1% (v/v) of PHMB. The result from dipping process showed that various concentrations of PHMB can greatly influence on the results; the interaction of 55 ppm AgNPs and 0.75% of PHMB offered good inhibition effect with the least amount of color change on bio-fibers.

Biofunctionalization of Natural Fiber-Reinforced Biocomposites for Biomedical Applications

“…Silver NPs have contributed significantly to advances in medical textiles that include the production of wound dressings and protective coatings for medic devices [133]. In fact, the combination of these NPs with biocomposites is the most explored, with exceptional bactericidal properties being identified in cotton-, linen-, sugarcane bagasse-, silk-and jute-reinforced composites [13,[81][82][83][84][85]. The bimetallic NPs comprehend those NPs that combine more than one metal or are produced from metallic alloys.…”

Novel Antimicrobial Agents and Processes for Textile Applications

“…Electrostatic and hydrophobic interactions occur with microbial cell membranes, resulting in cell membrane disruption and lethal leakage of cytoplasmic materials. Its antibacterial activity increases with the level of polymerization [28]. Some PHMB-based textile products, such as Biozac ZS and Reputex ® , have already appeared on the market as finishing products [29].…”