The role of positron emission tomography in the evaluation of inflammatory bowel disease

Chandler, Matthew; Zeddun, Steven; Borum, Marie L.

doi:10.1111/j.1749-6632.2011.06032.x

Cited by 13 publications

(6 citation statements)

References 21 publications

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“…Indeed, it has been demonstrated that the quantification of the intestinal glucose uptake as measured by 18 F-FDG PET/CT is quite variable, and pathologic findings are sometimes not readily differentiable from regular intestinal segments. By using SUV max as published previously by Toriihara et al (28) as a cutoff value, we were also only able to detect 50% of superficial ulcerations and 58% of erythema, indicating that endoscopic evaluations are favorable to characterize mucosal disease activity. Corresponding with the clinical data, the increase of glucose metabolism observed within DSS-induced lesions without epithelial defects was as low as 20% from baseline.…”

Section: Discussionmentioning

confidence: 61%

Translational ¹⁸F-FDG PET/CT Imaging to Monitor Lesion Activity in Intestinal Inflammation

et al. 2013

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Section: Discussionmentioning

confidence: 61%

Translational ¹⁸F-FDG PET/CT Imaging to Monitor Lesion Activity in Intestinal Inflammation

et al. 2013

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“…Reported studies in the literature about the use of FDG-PET in IBD—although few in number—concluded that this imaging modality holds potential in evaluating disease activity and providing an objective assessment of the severity of bowel inflammation. Despite these findings, overall not enough literature has been published to support a role for FDG-PET for diagnostic purposes [40, 53]. FDG-PET correlates globally well with clinical activity scores and may be useful when conventional imaging fails to yield a conclusive diagnosis [54].…”

Section: Autoimmune Diseasesmentioning

confidence: 99%

The Use of18F-FDG-PET/CT for Diagnosis and Treatment Monitoring of Inflammatory and Infectious Diseases

Glaudemans

Vries

Galli³

et al. 2013

Clinical and Developmental Immunology

213

128

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FDG-PET, combined with CT, is nowadays getting more and more relevant for the diagnosis of several infectious and inflammatory diseases and particularly for therapy monitoring. Thus, this paper gives special attention to the role of FDG-PET/CT in the diagnosis and therapy monitoring of infectious and inflammatory diseases. Enough evidence in the literature already exists about the usefulness of FDG-PET/CT in the diagnosis, management, and followup of patients with sarcoidosis, spondylodiscitis, and vasculitis. For other diseases, such as inflammatory bowel diseases, rheumatoid arthritis, autoimmune pancreatitis, and fungal infections, hard evidence is lacking, but studies also point out that FDG-PET/CT could be useful. It is of invaluable importance to have large prospective multicenter studies in this field to provide clear answers, not only for the status of nuclear medicine in general but also to reduce high costs of treatment.

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“…[ 18 F]FDG PET/CT is considered positive for IBD when a segmental and significant increased glucose uptake in the intestinal tract is observed [ 226 ]. In addition, the uptake distribution pattern can be useful to discriminate between CD or UC: CD can involve any segment of the GI tract, more frequently the distal small bowel, showing discontinuous patches of inflammation; UC primarily involves the rectum with a proximally extension in a continuous way [ 233 ].…”

Section: Resultsmentioning

confidence: 99%

State of the art of 18F-FDG PET/CT application in inflammation and infection: a guide for image acquisition and interpretation

Casali

Lauri

Altini

et al. 2021

Clin Transl Imaging

103

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Aim The diagnosis, severity and extent of a sterile inflammation or a septic infection could be challenging since there is not one single test able to achieve an accurate diagnosis. The clinical use of 18F-fluorodeoxyglucose ([ 18 F]FDG) positron emission tomography/computed tomography (PET/CT) imaging in the assessment of inflammation and infection is increasing worldwide. The purpose of this paper is to achieve an Italian consensus document on [ 18 F]FDG PET/CT or PET/MRI in inflammatory and infectious diseases, such as osteomyelitis (OM), prosthetic joint infections (PJI), infective endocarditis (IE), prosthetic valve endocarditis (PVE), cardiac implantable electronic device infections (CIEDI), systemic and cardiac sarcoidosis (SS/CS), diabetic foot (DF), fungal infections (FI), tuberculosis (TBC), fever and inflammation of unknown origin (FUO/IUO), pediatric infections (PI), inflammatory bowel diseases (IBD), spine infections (SI), vascular graft infections (VGI), large vessel vasculitis (LVV), retroperitoneal fibrosis (RF) and COVID-19 infections. Methods In September 2020, the inflammatory and infectious diseases focus group (IIFG) of the Italian Association of Nuclear Medicine (AIMN) proposed to realize a procedural paper about the clinical applications of [ 18 F]FDG PET/CT or PET/MRI in inflammatory and infectious diseases. The project was carried out thanks to the collaboration of 13 Italian nuclear medicine centers, with a consolidate experience in this field. With the endorsement of AIMN, IIFG contacted each center, and the pediatric diseases focus group (PDFC). IIFG provided for each team involved, a draft with essential information regarding the execution of [ 18 F]FDG PET/CT or PET/MRI scan (i.e., indications, patient preparation, standard or specific acquisition modalities, interpretation criteria, reporting methods, pitfalls and artifacts), by limiting the literature research to the last 20 years. Moreover, some clinical cases were required from each center, to underline the teaching points. Time for the collection of each report was from October to December 2020. Results Overall, we summarized 291 scientific papers and guidelines published between 1998 and 2021. Papers were divided in several sub-topics and summarized in the following paragraphs: clinical indications, image interpretation criteria, future perspectivess and new trends (for each single disease), while patient preparation, image acquisition, possible pitfalls and

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The role of positron emission tomography in the evaluation of inflammatory bowel disease

Cited by 13 publications

References 21 publications

Translational ¹⁸F-FDG PET/CT Imaging to Monitor Lesion Activity in Intestinal Inflammation

Translational ¹⁸F-FDG PET/CT Imaging to Monitor Lesion Activity in Intestinal Inflammation

The Use of18F-FDG-PET/CT for Diagnosis and Treatment Monitoring of Inflammatory and Infectious Diseases

State of the art of 18F-FDG PET/CT application in inflammation and infection: a guide for image acquisition and interpretation

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The role of positron emission tomography in the evaluation of inflammatory bowel disease

Cited by 13 publications

References 21 publications

Translational 18F-FDG PET/CT Imaging to Monitor Lesion Activity in Intestinal Inflammation

Translational 18F-FDG PET/CT Imaging to Monitor Lesion Activity in Intestinal Inflammation

The Use of18F-FDG-PET/CT for Diagnosis and Treatment Monitoring of Inflammatory and Infectious Diseases

State of the art of 18F-FDG PET/CT application in inflammation and infection: a guide for image acquisition and interpretation

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Resources

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Translational ¹⁸F-FDG PET/CT Imaging to Monitor Lesion Activity in Intestinal Inflammation

Translational ¹⁸F-FDG PET/CT Imaging to Monitor Lesion Activity in Intestinal Inflammation