Translational <sup>18</sup>F-FDG PET/CT Imaging to Monitor Lesion Activity in Intestinal Inflammation

Bettenworth, Dominik; Reuter, Stefan; Hermann, Sven; Weckesser, Matthias; Kerstiens, Linda; Stratis, Athanasios; Nowacki, Tobias M.; Ross, Matthias; Lenze, Frank; Edemir, Bayram; Maaser, Christian; Pap, Thomas; Koschmieder, Steffen; Heidemann, Jan; Schäfers, Michael; Lügering, Andreas

doi:10.2967/jnumed.112.112623

Cited by 50 publications

(28 citation statements)

References 22 publications

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“…Nevertheless, 10 to 15% of all colorectal IBDs cases cannot be classified as UC or CD [60]. In order to provide information concerning the inflammatory processes in IBD, 18 F-FDG PET imaging has been used in preclinical studies [25, 61, 62] and clinical studies [61, 63–67], especially in pediatric populations [64, 65, 68], and exhibited good diagnostic performances in patients with suspected IBD [58, 69]. Despite the well-known TSPO overexpression in colon cancer [70] and the knowledge that TSPO regulates the growth of colorectal cancer cells [71] which is also an unfavorable prognostic factor in stage III colorectal cancer [72], the involvement of TSPO in IBDs and dysplasia has not yet been completely investigated.…”

Section: Tspo Pet Imaging Of Psidsmentioning

confidence: 99%

TSPO PET Imaging: From Microglial Activation to Peripheral Sterile Inflammatory Diseases?

Largeau

Dupont

Guilloteau

et al. 2017

Contrast Media & Molecular Imaging

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Peripheral sterile inflammatory diseases (PSIDs) are a heterogeneous group of disorders that gathers several chronic insults involving the cardiovascular, respiratory, gastrointestinal, or musculoskeletal system and wherein inflammation is the cornerstone of the pathophysiology. In PSID, timely characterization and localization of inflammatory foci are crucial for an adequate care for patients. In brain diseases, in vivo positron emission tomography (PET) exploration of inflammation has matured over the last 20 years, through the development of radiopharmaceuticals targeting the translocator protein-18 kDa (TSPO) as molecular biomarkers of activated microglia. Recently, TSPO has been introduced as a possible molecular target for PSIDs PET imaging, making this protein a potential biomarker to address disease heterogeneity, to assist in patient stratification, and to contribute to predicting treatment response. In this review, we summarized the major research advances recently made in the field of TSPO PET imaging in PSIDs. Promising preliminary results have been reported in bowel, cardiovascular, and rheumatic inflammatory diseases, consolidated by preclinical studies. Limitations of TSPO PET imaging in PSIDs, regarding both its large expression in healthy peripheral tissues, unlike in central nervous system, and the production of peripheral radiolabeled metabolites, are also discussed, regarding their possible consequences on TSPO PET signal's quantification.

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Section: Tspo Pet Imaging Of Psidsmentioning

confidence: 99%

TSPO PET Imaging: From Microglial Activation to Peripheral Sterile Inflammatory Diseases?

Largeau

Dupont

Guilloteau

et al. 2017

Contrast Media & Molecular Imaging

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“…9/13 patients who completed PET scanning both at baseline and a median [range] of 12 [11][12][13][14][15][16][17][18] weeks after initiation of anti-TNF treatment had favourable clinical responses 27 (median [range] responder ΔHBI = 5 [3][4][5][6][7][8][9]; non-responder ΔHBI = 1[-1-2]), (Table 1). …”

Section: Contrasting Fdg-pet Measures In Responders Versus Non-responmentioning

confidence: 99%

“…However, there have been no systematic prospective studies with defined scanning intervals to further investigate this. Several well-designed experiments in appropriate murine models [14][15][16] , as well as human studies in other chronic inflammatory conditions 17,18 have produced encouraging results, but a longitudinal and test-retest reliability data are lacking.…”

Section: Introductionmentioning

confidence: 99%

Role of 18F-fluorodeoxyglucose Positron Emission Tomography in the Monitoring of Inflammatory Activity in Crohnʼs Disease

Russo¹,

Khan

Janisch

et al. 2016

Inflammatory Bowel Diseases

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“…More recently 18 FDG-PET/CT has been found to be useful in detecting inflamed areas throughout the entire intestinal tract in inflammatory bowel diseases [44]. Furthermore, two preliminary case reports suggest that 18 FDG-PET/CT is appropriate to assess the exact localization of GI acute GVHD and to evaluate treatment response [45, 46].…”

Section: Medical Imaging Testmentioning

confidence: 99%

New Insight for the Diagnosis of Gastrointestinal Acute Graft-versus-Host Disease

Malard

Mohty

2014

Mediators of Inflammation

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Allogeneic stem cell transplantation (allo-SCT) is a curative therapy for different life-threatening malignant and nonmalignant hematologic disorders. Graft-versus-host disease (GVHD) remains a major source of morbidity and mortality following allo-SCT, which limits the use of this treatment in a broader spectrum of patients. Early diagnostic of GVHD is essential to initiate treatment as soon as possible. Unfortunately, the diagnosis of GVHD may be difficult to establish, because of the nonspecific nature of the associated symptoms and of the numerous differential diagnosis. This is particularly true regarding gastrointestinal (GI) acute GVHD. In the recent years many progress has been made in medical imaging test and endoscopic techniques. The interest of these different techniques in the diagnosis of GI acute GVHD has been evaluated in several studies. With this background we review the contributions, limitations, and future prospect of these techniques in the diagnosis of GI acute GVHD.

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Translational ¹⁸F-FDG PET/CT Imaging to Monitor Lesion Activity in Intestinal Inflammation

Cited by 50 publications

References 22 publications

TSPO PET Imaging: From Microglial Activation to Peripheral Sterile Inflammatory Diseases?

TSPO PET Imaging: From Microglial Activation to Peripheral Sterile Inflammatory Diseases?

Role of 18F-fluorodeoxyglucose Positron Emission Tomography in the Monitoring of Inflammatory Activity in Crohnʼs Disease

New Insight for the Diagnosis of Gastrointestinal Acute Graft-versus-Host Disease

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Translational 18F-FDG PET/CT Imaging to Monitor Lesion Activity in Intestinal Inflammation

Cited by 50 publications

References 22 publications

TSPO PET Imaging: From Microglial Activation to Peripheral Sterile Inflammatory Diseases?

TSPO PET Imaging: From Microglial Activation to Peripheral Sterile Inflammatory Diseases?

Role of 18F-fluorodeoxyglucose Positron Emission Tomography in the Monitoring of Inflammatory Activity in Crohnʼs Disease

New Insight for the Diagnosis of Gastrointestinal Acute Graft-versus-Host Disease

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Translational ¹⁸F-FDG PET/CT Imaging to Monitor Lesion Activity in Intestinal Inflammation