Purpose. Study of perinatal and neonatal outcomes in newborns born to mothers with preeclampsia.Characteristics of children and research methods. Perinatal outcomes were analyzed in 559 mother–newborn pairs divided into 2 groups: Group 1 included 200 children to mothers with preeclampsia (143 with moderate and 57 with severe preeclampsia). Group 2 was composed of 359 newborns to mothers with a physiological course of pregnancy. The medical history, features of the course of pregnancy, delivery, and the early neonatal period were analyzed. The condition of newborns was assessed on the Apgar scale at 1 and 5 minutes, the assessment of physical development — using centile tables for full-term and premature newborns (INTERGROWTH-21st), the assessment of neuromuscular and physical maturity on the Ballard scale.Results. The study showed that children born to mothers with preeclampsia are significantly more likely to have metabolic and hematological disorders, a higher risk of developing infectious and inflammatory diseases, and a direct correlation with the period of manifestation and severity of preeclampsia. The higher occurrence of these conditions and the structure of pathological changes in the neonatal period led to a longer stay of children of this group after birth at newborn intensive care units, and also required observation at the second stage of nursing.Conclusion. Preeclampsia is a risk factor for neonatal complications. The identified features of adaptation in newborns from patients with preeclampsia and the structure of pathological conditions in the early neonatal period should determine the management tactics and timeliness of treatment and diagnostic measures aimed at improving the provision of medical care to the pregnant woman and subsequently the newborn.