The role of preoperative prophylactic antibiotic administration in periapical endodontic surgery: a randomized, prospective double‐blind placebo‐controlled study

Abstract

No statistically significant difference was found between clindamycin prophylaxis and placebo with regard to the prevention of postoperative infection in endodontic surgical procedures.

Efficacy of Prophylactic use of Antibiotics to Avoid Flare up During Root Canal Treatment of Nonvital Teeth: A Randomized Clinical Trial

“…The results of the current study concurred the results of the above later studies [12,19,20] as no statistical difference was found in incidence of the flare up regardless the use of amoxicillin before root canal treatment.…”

“…Patients were evaluated 1, 2 and 4 weeks after surgery. The infection rate in the clindamycin group was 1.6% (2 patients) and in the placebo group 3.2% (4 patients), which showed no statistical significant difference [20].…”

Pain, Swelling, and Surgical Site Infection

“…In a randomized controlled study, Lindeboom et al found no signifi cant difference between clindamycin prophylaxis and placebo with regard to the prevention of postoperative infection in endodontic surgical procedures [ 48 ]. In that study, they found a low infection rate of (2.3 %) indicating that antibiotic prophylaxis did not contribute to the prevention of postoperative infection [ 48 ].…”

“…The rationale for the use of antibiotics is based on the concept that the primary cause of the periradicular lesion is bacterial infection and that surgical intervention may result in a superimposed bacterial infection in the surgical site [ 48 ]. On the other hand, the unwarranted use of antibiotics may contribute to the development of resistant bacteria, adverse reactions, and allergies [ 48 ].…”

Update of guidelines for surgical endodontics – the position after ten years

“…11 There has been no evidence, however, to negate the consideration of a peri-operative chlorhexidine mouth rinse or non-steroidal antiinflammatory drugs (NSAIDs) to support healing and minimise swelling and postoperative discomfort.…”