The Role of Presepsin Obtained from Tracheal Aspirates in the Diagnosis of Early Onset Pneumonia in Intubated Newborns

Savic, Dragutin J.; Simovic, Aleksandra; Markovic, Slavica; Kostić, Gordana; Vuletic, Biljana; Radivojevic, S.; Lišanin, Marina; Igrutinović, Zoran; Pavlović, Radiša

doi:10.1007/s12098-018-2676-2

Cited by 7 publications

(6 citation statements)

References 18 publications

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“…PSP have been recently described to be increased in APTB patients, thus it could be helpful in the initial differential diagnosis between APTB and BCAP. Pneumonia development is also a challenging aspect of the intubated newborn [18], where blood sample collection is critical. In this context, PSP measurement in the tracheal aspirate was recently suggested as a complementary marker in the diagnosis of early onset neonatal pneumonia [19].…”

Section: Psp In Pulmonary Infectionsmentioning

confidence: 99%

Clinical application of presepsin as diagnostic biomarker of infection: overview and updates

Galliera

Massaccesi

Vecchi

et al. 2019

Clinical Chemistry and Laboratory Medicine (CCLM)

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The appropriate identification of bacterial infection is the basis for effective treatment and control of infective disease. Among this context, an emerging biomarker of infection is presepsin (PSP), recently described as early marker of different infections. PSP secretion has been shown to be associated with monocyte phagocytosis and plasmatic levels of PSP increase in response to bacterial infection and decrease after antibiotic treatment, therefore it can be considered a marker of activation of immune cell response towards an invading pathogen. Different methods have been developed to measure PSP and this review will briefly describe the different clinical fields of application of PSP, ranging from intensive care to neonatal infection, to orthopedic and pulmonary infection as well as fungal infections and cardiovascular infections.

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Section: Psp In Pulmonary Infectionsmentioning

confidence: 99%

Clinical application of presepsin as diagnostic biomarker of infection: overview and updates

Galliera

Massaccesi

Vecchi

et al. 2019

Clinical Chemistry and Laboratory Medicine (CCLM)

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“…Presepsin, soluble CD14 subtype (sDC14-ST), is well known biomarker of systemic bacterial infections. Isolated from blood, it proved to be more accurate biomarker of earlyonset sepsis compared to procalcitonin (PCT) and C-reactive protein (CRP) (8,9). Obtained from tracheal aspiration presepsin proved to be significant in the diagnosis of early neonatal pneumonia (9).…”

Section: Introductionmentioning

confidence: 99%

“…Isolated from blood, it proved to be more accurate biomarker of earlyonset sepsis compared to procalcitonin (PCT) and C-reactive protein (CRP) (8,9). Obtained from tracheal aspiration presepsin proved to be significant in the diagnosis of early neonatal pneumonia (9). Variables that are affecting C-reactive protein and procalcitonin values do not affect presepsin levels.…”

Section: Introductionmentioning

confidence: 99%

Can a Presepsin (Scd14-St) Obtained from Tracheal Aspirate Be a Biomarker for Early- Onset Neonatal Sepsis

Savic

Simovic

Pavlović

et al. 2020

Serbian Journal of Experimental and Clinical Research

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In absence of clear clinical signs and clear defi nition, neonatal sepsis is still one of the major cause of morbidity and mortality. Most researchs in past time was directional on fi nding new biomarkers with greater sensitivity and specifi city in detection of neonatal sepsis. Th e aim of our study was to investigate if presepsin obtained from tracheal asprate in intubated newborns, can be a novel biomarker of systemic bacterial infection. Our ‘’case control’’ study included 60 newborns, 11 with suspected neonatal sepsis. Tracheal aspirate for examination was taken in the usual toilets, in aseptic conditions, by lavage with 2 ml of 0.9% NaCl in Mucus suction set. In the same day were mesured presepsin (blood), CRP, PCT, leukocytes and neutrophyls, as well as blood culture. Our research showed higher levels for PCT and presepsin (blood) in septic newborns, as well as in newborns with clinical signs of SIRS. Presepsin obtained from a tracheal aspirate had high score for septic newborns. As the coeffi cients of simple linear correlation showed, there was quantitative agreement between presepsin (blood) with presepsin (tracheal aspirate)- increase in the value of one leads to an increase in other. In conjunction with an already validated markers of infection, presepsin obtained from tracheal aspirate cam be turned on in diagnostic procedures.

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“…A recent metaanalysis reported that serum presepsin had greater sensitivity than C-reactive protein and procalcitonin for detection of sepsis [5]. In this issue of the journal, Savić et al [6] studied 60 neonates ≥24 wk of gestation who were intubated and mechanically ventilated on the first day of life. These neonates were then classified into those with suspected pneumonia (n = 36) and others without pneumonia (n = 26), who were also control group.…”

mentioning

confidence: 99%

“…In the publication by Savić et al [6], the working definition of pneumonia was any two positive out of three criteria, clinical, radiological and microbiological, that is blood culture. However the distribution of these among cases and controls has not been given.…”

mentioning

confidence: 99%

Can Estimation of Presepsin Levels in Endotracheal Aspirate Predict Early Onset Pneumonia in Newborns?

Awasthi

2018

Indian J Pediatr

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The Role of Presepsin Obtained from Tracheal Aspirates in the Diagnosis of Early Onset Pneumonia in Intubated Newborns

Abstract: In intubated newborns, measurements of presepsin obtained from tracheal aspirate suggested that it can be used as a complementary marker in diagnosing early onset neonatal pneumonia.

Cited by 7 publications

References 18 publications

Clinical application of presepsin as diagnostic biomarker of infection: overview and updates

Clinical application of presepsin as diagnostic biomarker of infection: overview and updates

Can a Presepsin (Scd14-St) Obtained from Tracheal Aspirate Be a Biomarker for Early- Onset Neonatal Sepsis

Can Estimation of Presepsin Levels in Endotracheal Aspirate Predict Early Onset Pneumonia in Newborns?

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