The Role of Pro-Adrenomedullin as a Marker of Severe Bacterial Infection in Children: A Review

Garazzino, Silvia; Altieri, Elena; Denina, Marco

doi:10.3390/reports2030017

Cited by 3 publications

(8 citation statements)

References 29 publications

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“…Cases characterized by reduced glomerular filtration and renal failure have also been reported to be associated with increased ADM levels (Jordan et al 2014). Furthermore, the glucocorticoid hormone, lipopolysaccharides found in the cell wall of Gram-negative bacteria (Garayoa et al 2000), cytokines (Ghobrial et al 2020), anoxia, and inflammation-induced oxidative stress also cause increased ADM levels (Fahmey et al 2018, Garazzino et al 2019. ADM is known to have antibacterial and anti-inflammatory effects (Akpınar et al 2014).…”

Section: Discussionmentioning

confidence: 99%

“…Adrenomedullin is classified under the family of the calcitonin gene-related peptides (CGRP) (Geven et al 2018). In the body, ADM is produced in multiple tissues (Valenzulea-Sanchez et al 2016, Geven et al 2018, including the pulmonary tissue (Garazzino et al 2019). ADM has vasodilator (Akpınar et al 2014), diuretic and natriuretic (Rey et al 2013), bronchodilator (Önal et al 2018), antimicrobial (Garazzino et al 2019), antifungal andantiinflammatory (Akpınar et al 2014) effects.…”

Section: Introductionmentioning

confidence: 99%

“…It is not possible to measure blood adrenomedullin levels as this peptide hormone rapidly binds to its carrier receptors, has a short half-life and is rapidly metabolized (Geven et al 2018). Therefore, measurements are targeted at the mid-regional fragment of ADM, referred to as mid-regional proadrenomedullin (MR-proADM) (Sönmezer and Tülek 2015, Önal et al 2018, Garazzino et al 2019). This study was aimed at determining alterations in the sTREM-1 and MR-proADM levels of cattle diagnosed with pneumonia, based on clinical and radiographic findings.…”

Section: Introductionmentioning

confidence: 99%

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Serum Levels of Mid-Regional Pro-adrenomedullin and Soluble Triggering Receptor Expressed on Myeloid Cells in Cattle with Pneumonia

SEZER

Akyüz

Merhan

et al. 2023

Kocatepe Veterinary Journal

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This study was aimed at the determination of the serum levels of two inflammatory biomarkers, namely, mid-regional pro-adrenomedullin and soluble triggering receptor expressed on myeloid cells, as well as some biochemical and hematological parameters in cattle diagnosed with pneumonia. For this purpose, 40 patient female cattle, which were aged 2-7 years and displayed coughing, dyspnea, nasal discharge, anorexia and abdominal respiration, and 15 healthy female cattle within the same age range, were evaluated. The diseased cattle underwent clinical and radiological examinations and were sampled for blood prior to receiving treatment. The healthy subjects also underwent clinical examination and were sampled for blood once. The blood samples were used for biochemical and hematological measurements. The healthy and diseased cattle showed statistically significant differences for the serum levels of mid-regional pro-adrenomedullin and soluble triggering receptor expressed on myeloid cells (P

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Serum Levels of Mid-Regional Pro-adrenomedullin and Soluble Triggering Receptor Expressed on Myeloid Cells in Cattle with Pneumonia

SEZER

Akyüz

Merhan

et al. 2023

Kocatepe Veterinary Journal

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“…ADM is synthesized and released during sepsis (Jordan et al, 2014). In addition, ADM also has antimicrobial (Garazzino et al, 2019), antifungal, and anti-inflammatory effects (Allaker et al, 2006;Miguel et al, 2011;Bernal-Morell et al, 2018). Mid-regional-pro-adrenomedullin (MR-Pro-ADM) is a 48-amino acid fragment that shows the activity and level of ADM (Stolz et al, 2008;Miguel et al, 2011;Abd Elmouttaleb et al,2016;Valenzulea-Sanchez et al, 2016).The half-life of MR-Pro-ADM is higher than that of ADM.…”

Section: Introductionmentioning

confidence: 99%

sTREM-1, MR-Pro-Adrenomedullin, clinical biochemistry and hematology in calves with neonatal sepsis

Sezer,

Gökce

2024

J Hellenic Vet Med Soc

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This study aimed to determine the changes in biochemical and hematological parameters and the expression of soluble triggering receptor expressed on myeloid cells-1 (sTREM 1) and mid-regional-pro-adrenomedullin (MR-Pro-ADM) on myeloid cells during treatment in calves with neonatal sepsis. The study group comprised 21 calves, aged 1–16 days, that fit the sepsis criteria. The control group comprised 10 healthy calves of the same age. The clinical examinations of the calves in the study group were performed at certain hours before the treatment (hour 0) and during the treatment (12th, 24th, 48th, and 72nd hours). The blood samples were taken from the vena jugularis before and during treatment from the sick calves and once from the healthy calves. The sTREM-1 levels before treatment (0 h), during treatment (12th, 24th, 48th, and 72nd hours) and control group was follows 59.17±2.58 ng/L, 57.07±1.65 ng/L, 57.27±2.07 ng/L, 56.64±1.97 ng/L, 57.58±2.18 ng/L and 75.60±2.57 ng/L,39 respectively. The MR-Pro-ADM levels before treatment (0 h), during treatment (12th, 24th, 48th, and 72nd hours) and control group was follows; 117.88±7.75 ng/L, 113.63±5.18 ng/L, 109.97±5.25 ng/L, 114.50±5.35 ng/L, 111,84±5.63 ng/L,65.31±2.81 ng/L, respectively. The serum MR-Pro-ADM levels in calves with sepsis were significantly higher than those in the control group before and during treatment (P < 0.05). Also, the serum sTREM-1 level was significantly lower before and after treatment in the sepsis group compared with the control group (P < 0.05). MR-Pro-ADM and sTREM-1 were more important, especially in terms of diagnosis in evaluating calves with neonatal sepsis.

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“…Research assessing MR-proADM as a predictive diagnostic biomarker has been increasing in recent years with researchers investigating its role in paediatrics. A recent systematic narrative review suggested that MR-proADM may have a diagnostic role in the diagnosis of serious bacterial infections (non-IBI) in children as well as in non-infective inflammatory conditions such as juvenile arthritis [ 17 ]. However, a systematic review is required to determine if sufficient research exists to describe the role of MR-proADM in the diagnosis of IBI in children.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic value of mid-regional pro-Adrenomedullin as a biomarker of invasive bacterial infection in children: a systematic review

et al. 2022

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Background Invasive bacterial infections (IBI) in children present a difficult clinical challenge. They are often life-threatening, however in the early stages they can be hard to differentiate from benign viral infections. This leaves clinicians with the risk of missing a serious IBI diagnosis or inappropriately using antimicrobials in a child with a viral infection- contributing to the ongoing development of increased antimicrobial resistance. Hence, biomarkers which could aid in early detection of IBI and differentiation from viral infections are desirable. Mid-Regional pro-Adrenomedullin (MR-proADM) is a biomarker which has been associated with IBI. The aim of this systematic review was to determine its diagnostic accuracy in identifying children with IBI. Methods A strategy was devised to search online databases MEDLINE, Embase, Web of Science and Scopus for human clinical trials reporting the accuracy of MR-proADM in children. Against predesigned inclusion and exclusion criteria full texts were selected for inclusion and data extraction. True positives, false positives, true negatives and false negatives were extracted from each included study to fill 2 × 2 tables. Using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) tool methodological quality of each study was assessed. Results A total of 501 articles were initially identified. After the removal of duplicates and abstract screening 11 texts were fully reviewed and four texts (totaling 1404 patients) were included in the systematic analysis. Only one study was of a high quality and that study accounted for the vast majority of patients. A single study reported the diagnostic accuracy of MR-proADM for invasive bacterial infection reporting an Area under the Curve of 0.69. The paucity of available studies made meta-analysis and studies of heterogeneity impossible. Conclusion There is a paucity of research regarding the diagnostic accuracy of MR-proADM in the diagnosis of invasive bacterial infections in children. Initial results would suggest that MR-proADM testing alone is poor at identifying IBI in young children. It remains unclear if MR-proADM performs differently in older children or in children with signs and symptoms of IBI. Trial registration PROSPERO CRD42018096295.

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The Role of Pro-Adrenomedullin as a Marker of Severe Bacterial Infection in Children: A Review

Cited by 3 publications

References 29 publications

Serum Levels of Mid-Regional Pro-adrenomedullin and Soluble Triggering Receptor Expressed on Myeloid Cells in Cattle with Pneumonia

Serum Levels of Mid-Regional Pro-adrenomedullin and Soluble Triggering Receptor Expressed on Myeloid Cells in Cattle with Pneumonia

sTREM-1, MR-Pro-Adrenomedullin, clinical biochemistry and hematology in calves with neonatal sepsis

Diagnostic value of mid-regional pro-Adrenomedullin as a biomarker of invasive bacterial infection in children: a systematic review

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