This study analyzes economic developments to map the economic potential and leading sectors in improving the economy in South Kalimantan. Through the presence of Special Economic Zones (SEZ) it is expected to be able to accommodate industrial activities, exports and imports as well as other economic activities in improving the regional economy so that the purpose of this research is to explore the potential of the economy and leading sectors in developing Special Economic Zone (SEZ) in South Kalimantan Province. The research method used in this study is quantitative. Through secondary data taken from bps of South Kalimantan Province related to Gross Regional Domestic Product (GRDP), this study was analyzed using Loqation Quotient analysis and shift method Share to explore economic potential in a comparative manner and determine competitively leading sectors in South Kalimantan. the results showed that through the economic potential of LQ there are 7 sectors that can be developed while from the shift share as many as 9 leading sectors a competitive pickle can be developed in building a Special Economic Zone (SEZ) in South Kalimantan Province.