The role of radioiodine therapy in benign nodular goitre

Bonnema, Steen Joop; Fast, Søren

doi:10.1016/j.beem.2014.02.001

Cited by 27 publications

(30 citation statements)

References 90 publications

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“…Several recent articles [77] have indicated that these adverse effects are probably dose-dependent and are negligible with lower rhTSH doses. According to Bonnema et al [77], the optimal dose of rhTSH to improve radioiodine therapy is most likely in the range of 0.03-0.1 mg.…”

Section: Recombinant Human Tsh-stimulated Radioiodine Therapymentioning

confidence: 97%

“…This problem may be solved by increasing the radioiodine uptake (RAIU) in such nodular goiters [77]. For this purpose, recent studies using rhTSH in preparation for radioiodine therapy have shown good results [78].…”

Section: Recombinant Human Tsh-stimulated Radioiodine Therapymentioning

confidence: 99%

“…According to Bonnema et al [77], the optimal dose of rhTSH to improve radioiodine therapy is most likely in the range of 0.03-0.1 mg. Significant improvement in RAIU by the thyroid is obtained in this dose range, with minimization of the risk of glandular swelling and temporary thyrotoxicosis.…”

Section: Recombinant Human Tsh-stimulated Radioiodine Therapymentioning

confidence: 99%

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Etiopathology, clinical features, and treatment of diffuse and multinodular nontoxic goiters

Knobel

2015

J Endocrinol Invest

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Goiter, an enlargement of the thyroid gland, is a common problem in clinical practice associated with iodine deficiency, increase in serum thyroid-stimulating hormone (TSH) level, natural goitrogens, smoking, and lack of selenium and iron. Evidence suggests that heredity also has an important role in the etiology of goiter. The current classification divides goiter into diffuse and nodular, which may be further subdivided into toxic (associated with symptoms of hyperthyroidism, suppressed TSH or both), or nontoxic (associated with a normal TSH level). Nodular thyroid disease with the presence of single or multiple nodules requires evaluation due to the risk of malignancy, toxicity, and local compressive symptoms. Measurement of TSH, accurate imaging with high-resolution ultrasonography or computed tomography, and fine-needle aspiration biopsy are the appropriate methods for evaluation and management of goiter. This review discusses the clinical presentation, diagnostic evaluation, and treatment considerations of nontoxic diffuse and nodular goiters.

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Section: Recombinant Human Tsh-stimulated Radioiodine Therapymentioning

confidence: 97%

Section: Recombinant Human Tsh-stimulated Radioiodine Therapymentioning

confidence: 99%

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Etiopathology, clinical features, and treatment of diffuse and multinodular nontoxic goiters

Knobel

2015

J Endocrinol Invest

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“…11,12 In the past decades, treatment with radioactive iodine has also been employed leading to a 35-50% reduction in goiter volume. 13 Thyroid hormone suppressive therapy for individuals with thyroid nodules is optional, but as there is no agreement on the efficacy and safety of this method, its routine use is not recommended.…”

Section: Introductionmentioning

confidence: 99%

High-intensity focused ultrasound for thyroid nodule ablation: the evidence to date

Кovatcheva¹,

Zaletel²

2017

RMI

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Thyroid nodules are common in occurrence and most of them are benign in nature. Some of these nodules are to be treated as they continue to grow or cause undesirable symptoms. Recently, several minimally invasive thermal ablation techniques have been introduced to overcome the complications of traditional methods such as surgery. High-intensity focused ultrasound (HIFU) is the latest advance in treatment modalities, which is a noninvasive procedure that permits localized target destruction without affecting the surrounding tissues. HIFU is currently used in the treatment of various solid malignant and benign tumors. The purpose of this review is to provide an introduction to the literature, principles, and advances of HIFU therapy of benign thyroid nodules, as well as to provide a discussion on its efficacy, complications, and future.

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“…In contrast, the accumulation of radioisotopes in labeled cells can be potentially destructive, as it is for thyroid cells treated with radioiodine. 5,6 Despite the drawbacks, radioisotopes are actively involved in stem cell tracking both in the preclinical setting and in clinical trials. 7,8 Radioisotopes can be used for direct labeling of cells, but also can be conjugated with ligands of specific receptors present in a particular type of cell.…”

Section: Introductionmentioning

confidence: 99%

Pre- and postmortem imaging of transplanted cells

Andrzejewska

Nowakowski

Janowski

et al. 2015

IJN

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Therapeutic interventions based on the transplantation of stem and progenitor cells have garnered increasing interest. This interest is fueled by successful preclinical studies for indications in many diseases, including the cardiovascular, central nervous, and musculoskeletal system. Further progress in this field is contingent upon access to techniques that facilitate an unambiguous identification and characterization of grafted cells. Such methods are invaluable for optimization of cell delivery, improvement of cell survival, and assessment of the functional integration of grafted cells. Following is a focused overview of the currently available cell detection and tracking methodologies that covers the entire spectrum from pre- to postmortem cell identification.

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The role of radioiodine therapy in benign nodular goitre

Cited by 27 publications

References 90 publications

Etiopathology, clinical features, and treatment of diffuse and multinodular nontoxic goiters

Etiopathology, clinical features, and treatment of diffuse and multinodular nontoxic goiters

High-intensity focused ultrasound for thyroid nodule ablation: the evidence to date

Pre- and postmortem imaging of transplanted cells

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