The role of reactive oxygen species in screening anticancer agents

Xu, Xiaohui; Dang, Zilong; Sun, Tao; Zhang, Shengping; Zhang, Hongyan

doi:10.4103/ctm.ctm_6_18

Cited by 7 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several anticancer drugs act by inhibiting and suppressing cancer progression through ROS-mediated cell death [63]. ROS are highly reactive and extremely unstable molecules.…”

Section: Production Of Rosmentioning

confidence: 99%

On the path to gold: Monoanionic Au bisdithiolate complexes with antimicrobial and antitumor activities

Sousa

Leitão

Silva

et al. 2020

Journal of Inorganic Biochemistry

View full text Add to dashboard Cite

The emergence of resistance to antimicrobial and anticancer drugs poses severe threats to public health worldwide, highlighting the need for more efficient treatments. Here, four monoanionic Au bisdithiolate complexes [Au(mnt) 2 ]-(where mnt = 1,1dicyanoethylene-2,2-dithiolate)(1), [Au(i-mnt) 2 ]-(where i-mnt = 2,2-dicyanoethylene-1,1-dithiolate)(2), [Au(cdc) 2 ]-(where cdc = cyanodithioimido carbonate)(3), and [Au(qdt) 2 ]-(where qdt = quinoxaline-2,3-dithiolate)(4) were screened for their antimicrobial and antitumor activities. Complexes 3 and 4 showed antibacterial activity against Staphylococcus aureus (MIC = 15.3 and 14.7 µg/mL, respectively). Complex 3

show abstract

“…Several anticancer drugs act by inhibiting and suppressing cancer progression through ROS-mediated cell death [63]. ROS are highly reactive and extremely unstable molecules.…”

Section: Production Of Rosmentioning

confidence: 99%

On the path to gold: Monoanionic Au bisdithiolate complexes with antimicrobial and antitumor activities

Sousa

Leitão

Silva

et al. 2020

Journal of Inorganic Biochemistry

View full text Add to dashboard Cite

show abstract

“…ROS is regarded as the target of the anticancer agents in cancer therapy. Prooxidants as anticancer agents induce apoptosis in cancer cells through promoting ROS signalling pathways and weakening the antioxidant defence system of cancer cells [35]. Flavonoids display prooxidant activity modulating cell signalling which is thought to be directly proportional to the total number of hydroxyl groups [36].…”

Section: Introductionmentioning

confidence: 99%

Secondary Metabolites Profiling of Acinetobacter baumannii Associated with Chili (Capsicum annuum L.) Leaves and Concentration Dependent Antioxidant and Prooxidant Properties

Monowar

Rahman²,

Bhore

et al. 2019

BioMed Research International

View full text Add to dashboard Cite

Secondary bioactive compounds of endophytes are inevitable biomolecules of therapeutical importance. In the present study, secondary metabolites profiling of an endophytic bacterial strain, Acinetobacter baumannii, were explored using GC-MS study. Presence of antioxidant substances and antioxidant properties in chloroform (CHL), diethyl ether (DEE), and ethyl acetate (EA) crude extracts of the endophytic bacteria were studied. Total phenolic content (TPC), total flavonoid content (TFC), total antioxidant capacity (TAC), 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, and ferrous ion chelating assay were evaluated. A total of 74 compounds were identified from the GC-MS analysis of the EA extract representing mostly alkane compounds followed by phenols, carboxylic acids, aromatic heterocyclic compounds, ketones, aromatic esters, aromatic benzenes, and alkenes. Among the two phenolic compounds, namely, phenol, 2,4-bis(1,1-dimethylethyl)- and phenol, 3,5-bis(1,1-dimethylethyl)-, the former was found in abundance (11.56%) while the latter was found in smaller quantity (0.14%). Moreover, the endophytic bacteria was found to possess a number of metal ions including Fe(II) and Cu(II) as 1307.13 ± 2.35 ppb and 42.38 ± 0.352 ppb, respectively. The extracts exhibited concentration dependent antioxidant and prooxidant properties at high and low concentrations, respectively. The presence of phenolic compounds and metal ions was believed to play an important role in the antioxidant and prooxidant potentials of the extracts. Further studies are suggested for exploring the untapped resource of endophytic bacteria for the development of novel therapeutic agents.

show abstract