The Role of Recombinant Secretory Leukocyte Protease Inhibitor to CD163, FGF-2, IL-1 and IL-6 Expression in Skin Wound Healing

Munadziroh, Elly; Putri, Giovani Anggasta; Ristiana, Vera; Agustantina, Titien Hary; Nirwana, Intan; Razak, Fathilah Abdul; Surboyo, Meircurius Dwi Condro

doi:10.2147/ccid.s358897

Cited by 5 publications

(2 citation statements)

References 41 publications

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“…Second, we found a negative correlation between TGF-β and SLPI and lysozyme levels in BAL, again reinforced by our in vitro results. SLPI has been shown to decrease TGF-β levels by regulating macrophage activation [33,34]. In regard to lysozyme, our in vitro results suggest that this AMP induces the differentiation of macrophages to a M1 phenotype, increasing TNF-α and decreasing TGF-β production.…”

Section: Discussionmentioning

confidence: 60%

Levels of Lysozyme and SLPI in Bronchoalveolar Lavage: Exploring Their Role in Interstitial Lung Disease

Osuna-Gómez,

Mulet,

Barril

et al. 2024

IJMS

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Interstitial lung diseases (ILDs) are characterized by inflammation or fibrosis of the pulmonary parenchyma. Despite the involvement of immune cells and soluble mediators in pulmonary fibrosis, the influence of antimicrobial peptides (AMPs) remains underexplored. These effector molecules display a range of activities, which include immunomodulation and wound repair. Here, we investigate the role of AMPs in the development of fibrosis in ILD. We compare the concentration of different AMPs and different cytokines in 46 fibrotic (F-ILD) and 17 non-fibrotic (NF-ILD) patients by ELISA and using peripheral blood mononuclear cells from in vitro stimulation in the presence of lysozyme or secretory leukocyte protease inhibitor (SLPI) from 10 healthy donors. We observed that bronchoalveolar lavage (BAL) levels of AMPs were decreased in F-ILD patients (lysozyme: p < 0.001; SLPI: p < 0.001; LL-37: p < 0.001; lactoferrin: p = 0.47) and were negatively correlated with levels of TGF-β (lysozyme: p = 0.02; SLPI: p < 0.001) and IL-17 (lysozyme: p < 0.001; SLPI: p < 0.001). We observed that lysozyme increased the percentage of CD86+ macrophages (p < 0.001) and the production of TNF-α (p < 0.001). We showed that lysozyme and SLPI were associated with clinical parameters (lysozyme: p < 0.001; SLPI: p < 0.001) and disease progression (lysozyme: p < 0.001; SLPI: p = 0.01). These results suggest that AMPs may play an important role in the anti-fibrotic response, regulating the effect of pro-fibrotic cytokines. In addition, levels of lysozyme in BAL may be a potential biomarker to predict the progression in F-ILD patients.

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Section: Discussionmentioning

confidence: 60%

Levels of Lysozyme and SLPI in Bronchoalveolar Lavage: Exploring Their Role in Interstitial Lung Disease

Osuna-Gómez,

Mulet,

Barril

et al. 2024

IJMS

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“…Associated Cytokines in Wound Healing[54][55][56][57][58][59][60][61][62][63][64][65][66][67][68][69][70][71][72] …”

mentioning

confidence: 99%

Neural and Inflammatory Interactions in Wound Healing

Zeng,

Pan,

Chaker

et al. 2024

Ann Plast Surg

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The skin is an intricate network of both neurons and immunocytes, where emerging evidence has indicated that the regulation of neural-inflammatory processes may play a crucial role in mediating wound healing. Disease associated abnormal immunological dysfunction and peripheral neuropathy are implicated in the pathogenesis of wound healing impairment. However, the mechanisms through which neural-inflammatory interactions modulate wound healing remain ambiguous. Understanding the underlying mechanisms may provide novel insights to develop therapeutic devices, which could manipulate neural-inflammatory crosstalk to aid wound healing. This review aims to comprehensively illustrate the neural-inflammatory interactions during different stages of the repair process. Numerous mediators including neuropeptides secreted by the sensory and autonomic nerve fibers and cytokines produced by immunocytes play an essential part during the distinct phases of wound healing.

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Synthesis of secretory leukocyte protease inhibitor using cell-free protein synthesis system

Hiroshima,

Kido,

Kido

et al. 2024

Odontology

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The Role of Recombinant Secretory Leukocyte Protease Inhibitor to CD163, FGF-2, IL-1 and IL-6 Expression in Skin Wound Healing

Cited by 5 publications

References 41 publications

Levels of Lysozyme and SLPI in Bronchoalveolar Lavage: Exploring Their Role in Interstitial Lung Disease

Levels of Lysozyme and SLPI in Bronchoalveolar Lavage: Exploring Their Role in Interstitial Lung Disease

Neural and Inflammatory Interactions in Wound Healing

Synthesis of secretory leukocyte protease inhibitor using cell-free protein synthesis system

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