The role of remnant cholesterol beyond low-density lipoprotein cholesterol in diabetes mellitus

Hu, Xiangming; Liu, Qunzhi; Guo, Xiaolu; Wang, Weimian; Yu, Bingyan; Liang, Beijia; Zhou, Yingling; Dong, Haojian; Lin, Jing

doi:10.1186/s12933-022-01554-0

Cited by 70 publications

(40 citation statements)

References 57 publications

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“…RCis gaining attention because of its close association with cardiovascular diseases [ 15 ]. Epidemiological studies have found that RC is also associated with hypertension [ 16 ], diabetes mellitus and its complications [ 17 , 18 ], nonalcoholic fatty liver disease [ 19 ], and chronic kidney disease [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Association of remnant cholesterol with depression among US adults

Wang

Shen

2023

BMC Psychiatry

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Background Remnant cholesterol is receiving increasing attention because of its association with various diseases. However, there have been no studies on remnant cholesterol levels and depression. Methods A cross-sectional analysis was performed based on the National Health and Nutrition Examination Survey (NHANES) 2005–2016. Depression was assessed using a Patient Health Questionnaire (PHQ-9). Fasting remnant cholesterol was calculated as the total cholesterol minus high-density lipoprotein cholesterol (HDL-C) minus low-density lipoprotein cholesterol (LDL-C). Logistic regression analysis with sampling weights was used to examine the association between remnant cholesterol concentration and depression. Results Among 8,263 adults enrolled in this study (weighted mean age, 45.65 years), 5.88% (weighted percentage) had depression. Compared to the participants without depression, those with depression had higher concentration of remnant cholesterol (weighted mean, 26.13 vs. 23.05, P < 0.001). There was a significant positive relationship between remnant cholesterol concentration and depression and multivariable-adjusted OR with 95% CI was 1.49 (1.02–2.17). Among the subgroup analyses, remnant cholesterol concentration was positively associated with depression among participants less than 60 years (OR, 1.62; 95% CI, 1.09–2.42), male (OR, 2.02; 95% CI, 1.01–4.05), BMI under 30 (OR, 1.83; 95% CI, 1.14–2.96), and those with diabetes (OR, 3.88; 95% CI, 1.43–10.49). Conclusions Remnant cholesterol concentration positively correlated with depression, suggesting that a focus on remnant cholesterol may be useful in the study of depression.

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Section: Introductionmentioning

confidence: 99%

Association of remnant cholesterol with depression among US adults

Wang

Shen

2023

BMC Psychiatry

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“…The urine total arsenic concentration showed a slight upward trend in the last three survey cycles. The substance concentration below the detection limit was replaced by the lower limit of detection (LLOD) divided by square root of 2 (LLOD/SQRT [ 2 ]). The lowest median (interquartile range (IQR)) of concentrations of total urine arsenic was 6.6 (3.42–13.47) μg/L from the survey cycle 2013 to 2014, and the detection limit was 0.26 μg/L ( Figure 2 ).…”

Section: Resultsmentioning

confidence: 99%

“…Among the spectrum of lipoproteins, there is no doubt that total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) concentrations are critically important affecting factors for the risk of cardiovascular diseases including Alzheimer’s disease (AD) [ 1 ], diabetes [ 2 ], or hypertension or Parkinson disease (PD) [ 3 ]. Cholesterol homeostasis is vital for proper cellular and systemic functions.…”

Section: Introductionmentioning

confidence: 99%

Linking the Low-Density Lipoprotein-Cholesterol (LDL) Level to Arsenic Acid, Dimethylarsinic, and Monomethylarsonic: Results from a National Population-Based Study from the NHANES, 2003–2020

Huang

2022

Nutrients

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Arsenic (As) contamination is a global public health problem. Elevated total cholesterol (TC) and low-density lipoprotein-cholesterol (LDL-C) are risk factors for cardiovascular diseases, but data on the association of urinary arsenic species’ level and LDL-C are limited. We performed an association analysis based on urinary arsenic species and blood TC and LDL-C in US adults. Methods: Urinary arsenic, arsenic acid (AA), dimethylarsinic (DMA), monomethylarsonic (MMA), TC, LDL-C, and other key covariates were obtained from the available National Health and Nutrition Examination Survey (NHANES) data from 2003 to 2020. Multiple linear regression analysis and generalized linear model are used to analyze linear and nonlinear relationships, respectively. Results: In total, 6633 adults aged 20 years were enrolled into the analysis. The median total urinary arsenic level was 7.86 µg/L. A positive association of urinary arsenic concentration quartiles was observed with TC (β: 2.42 95% CI 1.48, 3.36). The OR for TC of participants in the 80th versus 20th percentiles of urinary total arsenic was 1.34 (95% CI 1.13, 1.59). The OR for LDL-C of participants in the 80th versus 20th percentiles of urinary total arsenic was 1.36 (95% CI 1.15, 1.62). For speciated arsenics analysis, the OR for arsenic acid and TC was 1.35 (95% CI 1.02, 1.79), whereas the OR for DMA and LDL-L was 1.20 (95% CI 1.03, 1.41), and the OR for MMA and LDL-L was 1.30 (95% CI 1.11, 1.52). Conclusions: Urinary arsenic and arsenic species were positively associated with increased LDL-C concentration. Prevention of exposure to arsenic and arsenic species maybe helpful for the control of TC and LDL-C level in adults.

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“…Previous epidemiological studies found that elevated RC along with a higher prevalence of DM, as such RC may be a predictor of diabetes or prediabetes and hypertension [28,29]. Additionally, a study of a population of 7308 individuals recruited from CHNS showed that the concentration of RC was associated with DM beyond the LDL-C [30]. Besides, RC also had a substantial connection with the prediction or diagnosis of hypertension, and could be used as a blood marker for screening [31,32].…”

Section: Discussionmentioning

confidence: 96%

Remnant cholesterol is a risk factor for metabolic syndrome and cardiovascular disease: a cross-sectional study

Jin

François

et al. 2023

Preprint

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Background: Epidemiologic evidence suggested that remnant cholesterol (RC) is associated with the occurrence of cardiovascular disease (CVD). In recent years, RC has been connected with different types of cardiometabolic disorders. We aim to clarify the relationship among RC, metabolic syndrome (MetS) and subsequent CVD. Methods: We enrolled 7471 individuals into our study from China Health and Nutrition Survey in 2009 and followed participants till 2015. RC was calculated as total cholesterol minus low-density lipoprotein cholesterol minus high-density lipoprotein cholesterol. CVD was defined as myocardial infarction and stroke. Multivariate logistic regression models were used to evaluate the association between RC and MetS as well as CVD. The correlation between RC and MetS or its components were analyzed. We further investigated whether the association between RC and CVD was mediated by MetS. Results: Of all subjects, 24.73% were diagnosed with MetS and 3.58% developed CVD. Multivariate logistic regression analysis elucidated that the risk of MetS increased with RC tertiles and was elevated after adjusting all the confounder factors, (odds ratio: 3.50, 95% confidence interval: 3.22-3.80, P for trend <0.001). Meanwhile, we found that RC level is associated with the prevalence of all the components of MetS. Significant indirect effects of RC between MetS and CVD were found, with the index mediated at 60.90% of the association. Conclusions:Our study provides the evidence that RC level is independently associated with the prevalence of MetS and each component of MetS. MetS partially mediated the association between RC level and CVD risk.

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The role of remnant cholesterol beyond low-density lipoprotein cholesterol in diabetes mellitus

Cited by 70 publications

References 57 publications

Association of remnant cholesterol with depression among US adults

Association of remnant cholesterol with depression among US adults

Linking the Low-Density Lipoprotein-Cholesterol (LDL) Level to Arsenic Acid, Dimethylarsinic, and Monomethylarsonic: Results from a National Population-Based Study from the NHANES, 2003–2020

Remnant cholesterol is a risk factor for metabolic syndrome and cardiovascular disease: a cross-sectional study

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