The Role of Renal Replacement Therapy in the Management of Pharmacologic Poisonings

Mirrakhimov, Aibek E.; Barbaryan, Aram; Gray, Adam; Ayach, Taha

doi:10.1155/2016/3047329

Cited by 41 publications

(31 citation statements)

References 62 publications

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“…22,23 However the drug is readily dialyzable and cleared up from the body quickly, usually one or two hemodialysis session completely reverse the condition. 23,24 In our index case dialysis was not possible and it took longer time to resolve.…”

Section: Discussionmentioning

confidence: 82%

Drug Induced Encephalopathy in Patients with Chronic Kidney Disease: A Case Series

et al. 2018

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Drug induced encephalopathy is an established side effect of many drugs when used in a higher dose. Though we do not encounter this side effect frequently in our day to day practice, yet with renal impairment this is not uncommon. Even with a reduced dose many of these can precipitate encephalopathy in this special group of patients. We are presenting here a series of seven such cases of drug induced encephalopathy in patients with renal impairment.Birdem Med J 2018; 8(2): 172-176

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Section: Discussionmentioning

confidence: 82%

Drug Induced Encephalopathy in Patients with Chronic Kidney Disease: A Case Series

et al. 2018

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“…Other toxins that are commonly removed by RRT include alcohol poisoning, salicylate toxicity, lithium overdose, dabigatran, and sodium valproate poisoning. 22 …”

Section: Discussionmentioning

confidence: 99%

Renal Replacement Therapy Practices in India: A Nationwide Survey

Sodhi¹,

Phillips

Mishra³

et al. 2020

Indian Journal of Critical Care Medicine

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A bstract Introduction Renal replacement therapy (RRT) is utilized for patients admitted with acute kidney injury and is becoming indispensable for the treatment of critically ill patients. In low middle income and developing country like India, the epidemiological date about the practices of RRT in various hospitals setups in India are lacking. Renal replacement therapy although is being widely practiced in India, however, is not uniform or standardized. Moreover, the use of RRT beyond traditional indications has not only increased but has shifted from the ambit of the nephrologist and has come under the charge of intensivists. Aims and objectives The goal of the study was to record perceptions and current practices in RRT management among intensivists across Indian intensive care units (ICUs). Materials and methods A questionnaire including questions about hospital and ICU settings, availability of RRT, manpower availability, and RRT management in critically ill patients was formed by an expert panel of ICU physicians. The questionnaire was circulated online to Indian Society of Critical Care Medicine (ISCCM) members in October 2019. Results The facilities in government setups are scarce and undersupplied as compared to private or corporate setups in terms of ICU bed strength and availability of RRT. High cost of continuous renal replacement therapy (CRRT) makes their use restricted. Conclusion Resources of RRT in our country are limited, more in government setup. Improvement of the existing resources, training of personnel, and making RRT affordable are the challenges that need to be overcome to judiciously utilize these services to benefit critically ill patients. How to cite this article Sodhi K, Philips A, Mishra RC, Tyagi N, Dixit SB, Chaudhary D, et al. Renal Replacement Therapy Practices in India: A Nationwide Survey. Indian J Crit Care Med 2020;24(9):823–831.

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“…The reason lies in its pharmacokinetic properties. To be deemed dialyzable, a substance should have a volume of distribution (VD) of < 1 L/kg [9]. The VD of clonidine has been reported to be 1.7-2.9 L/kg, depending on the source [10].…”

Section: Discussionmentioning

confidence: 99%

In vivo Elimination of Clonidine by Continuous Venovenous Hemofiltration in Critically Ill Patients

et al. 2020

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Background: Clonidine is an α 2-agonist that is commonly used for sedation in the intensive care unit. When patients are on continuous venovenous hemofiltration (CVVH) in the presence of kidney dysfunction, the sieving coefficient of clonidine is required to estimate how much drug is removed by CVVH. In the present study, we measured the sieving coefficient of clonidine in critically ill, ventilated patients receiving CVVH. Methods: A total of 20 samples of plasma and ultrafiltrate of 3 patients on CVVH, using a standard 1.5 m 2 polyacrylonitrile AN69 membrane, during continuous clonidine infusion were collected. After correction for the effect of predilution, we calculated the sieving coefficient for clonidine. Results: The mean sieving coefficient of clonidine was 0.52 (SD 0.097). Conclusion: Using a polyacrylonitrile AN69 membrane in a CVVH machine, the in vivo sieving coefficient of clonidine was 0.52.

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The Role of Renal Replacement Therapy in the Management of Pharmacologic Poisonings

Cited by 41 publications

References 62 publications

Drug Induced Encephalopathy in Patients with Chronic Kidney Disease: A Case Series

Drug Induced Encephalopathy in Patients with Chronic Kidney Disease: A Case Series

Renal Replacement Therapy Practices in India: A Nationwide Survey

In vivo Elimination of Clonidine by Continuous Venovenous Hemofiltration in Critically Ill Patients

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