The role of respiratory syncytial virus in acute bronchiolitis in small children in northern Japan

Saijo, Masayuki; Takahashi, Satoru; Kokubo, Mitsunori; Saino, Tomoyuki; Ishii, Takumi; Inyaku, F; Takimoto, M; Takahashi, Youji

doi:10.1111/j.1442-200x.1994.tb03203.x

Cited by 18 publications

(14 citation statements)

References 16 publications

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“…1 In some cases, RSV infection can be fatal. 2 In temperate regions, RSV infection occurs each year in winter and spring.…”

Section: Introductionmentioning

confidence: 99%

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Respiratory syncytial virus subgroup A in hospitalized children in Zarqa, Jordan

Bdour

2001

Annals of Tropical Paediatrics

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The epidemiology of RSV infection was investigated in 271 children aged less than 2 years admitted to the Zarqa Government Hospital, Jordan with bronchiolitis or bronchopneumonia. Nasopharyngeal washings were cultured and RSV antigen was detected by the direct immunofluorescence technique. Of the 271 specimens, 69 (25.46%) were positive for RSV, representing 50.36% of the respiratory viruses. All RSV isolates were typed as subgroup A by monoclonal antibody and confirmed by RT-PCR. RSV was prevalent in the hospitalised children in the coldest months of the year. The epidemics began in January or February, peaked in spring and then disappeared in summer. This study supports the idea that RSV subgroup A is a major contributor to winter outbreaks of respiratory tract disease in children, and health care workers in Jordan should consider the diagnosis during January-May each year.

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“…1 In some cases, RSV infection can be fatal. 2 In temperate regions, RSV infection occurs each year in winter and spring.…”

Section: Introductionmentioning

confidence: 99%

“…[3][4][5] In tropical and semitropical regions, epidemics of RSV occur during the wet summer months. 1,6 Two RSV antigenic subgroups, A and B, have been recognized by their reactions with panels of monoclonal antibodies. 7 Sequence analysis allowed the classi cation of subgroup A and B strains into different genetic categories.…”

Section: Introductionmentioning

confidence: 99%

Respiratory syncytial virus subgroup A in hospitalized children in Zarqa, Jordan

Bdour

2001

Annals of Tropical Paediatrics

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“…The respiratory syncytial virus (RSV) is recognized as the single most frequent lower respiratory tract pathogen in infants and young children in developed countries but less is known for populations of developing countries 5,14,37 . RSV activity in the United States is monitored by the National Respiratory and Enteric Virus Surveillance System, a voluntary laboratory-based system started in 1990, but there is not a similar epidemiological system operating in developing countries, as yet 4 .…”

Section: Introductionmentioning

confidence: 99%

Clinical patterns and seasonal trends in respiratory syncytial virus hospitalizations in São Paulo, Brazil

Vieira

Stewien

Queiróz

et al. 2001

Rev. Inst. Med. trop. S. Paulo

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The respiratory viruses are recognized as the most frequent lower respiratory tract pathogens for infants and young children in developed countries but less is known for developing populations. The authors conducted a prospective study to evaluate the occurrence, clinical patterns, and seasonal trends of viral infections among hospitalized children with lower respiratory tract disease (Group A). The presence of respiratory viruses in children's nasopharyngeal was assessed at admission in a pediatric ward. Cell cultures and immunofluorescence assays were used for viral identification. Complementary tests included blood and pleural cultures conducted for bacterial investigation. Clinical data and radiological exams were recorded at admission and throughout the hospitalization period. To better evaluate the results, a non- respiratory group of patients (Group B) was also constituted for comparison. Starting in February 1995, during a period of 18 months, 414 children were included- 239 in Group A and 175 in Group B. In Group A, 111 children (46.4%) had 114 viruses detected while only 5 children (2.9%) presented viruses in Group B. Respiratory Syncytial Virus was detected in 100 children from Group A (41.8%), Adenovirus in 11 (4.6%), Influenza A virus in 2 (0.8%), and Parainfluenza virus in one child (0.4%). In Group A, aerobic bacteria were found in 14 cases (5.8%). Respiratory Syncytial Virus was associated to other viruses and/or bacteria in six cases. There were two seasonal trends for Respiratory Syncytial Virus cases, which peaked in May and June. All children affected by the virus were younger than 3 years of age, mostly less than one year old. Episodic diffuse bronchial commitment and/or focal alveolar condensation were the clinical patterns more often associated to Respiratory Syncytial Virus cases. All children from Group A survived. In conclusion, it was observed that Respiratory Syncytial Virus was the most frequent pathogen found in hospitalized children admitted for severe respiratory diseases. Affected children were predominantly infants and boys presenting bronchiolitis and focal pneumonias. Similarly to what occurs in other subtropical regions, the virus outbreaks peak in the fall and their occurrence extends to the winter, which parallels an increase in hospital admissions due to respiratory diseases.

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“…Children born preterm or with underlying cardiopulmonary disorders are at specially high risk of developing severe and lethal RSV respiratory tract infections (American Academy of Pediatrics 2003 ; Girard et al 2005 ;Saijo et al 1993Saijo et al , 1994. A reverse transcription loop-mediated isothermal amplifi cation (RT-LAMP) assay was developed by Shirato et al ( 2007 ) to amplify the genome of RSV subgroups A and B, in order to improve current diagnostic methods for RSV infection.…”

Section: Human Virusesmentioning

confidence: 99%

Rapid Detection of Viruses Using Loop-Mediated Isothermal Amplification (LAMP): A Review

Saharan

Khatri

Dingolia

et al. 2013

Biotechnology: Prospects and Applications

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Most of the diseases caused by viral infection are found to be fatal, and the diagnosis is diffi cult due to confusion with other causative agents. So, a highly effi cient molecular-based advance detection technique, i.e., loopmediated isothermal amplifi cation (LAMP) method, is developed for diagnosis of viral infections by various workers. It is based on amplifi cation of DNA at very low level under isothermal conditions, using a set of four specifi cally designed primers and a DNA polymerase with strand displacement activity. This technique is found to be superior than most of the molecular techniques like PCR, RT-PCR, and real-time PCR due to its high specifi city, sensitivity, and rapidity. Major advantage of LAMP method is its cost-effectiveness as it can be done simply by using water bath or dry bath. Here, in this review information regarding almost all the effective LAMP techniques which is developed so far for diagnosis of numerous viral pathogens is presented.

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The role of respiratory syncytial virus in acute bronchiolitis in small children in northern Japan

Cited by 18 publications

References 16 publications

Respiratory syncytial virus subgroup A in hospitalized children in Zarqa, Jordan

Respiratory syncytial virus subgroup A in hospitalized children in Zarqa, Jordan

Clinical patterns and seasonal trends in respiratory syncytial virus hospitalizations in São Paulo, Brazil

Rapid Detection of Viruses Using Loop-Mediated Isothermal Amplification (LAMP): A Review

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