This chapter considers classroom strategies that have been shown to support student science learning and discusses the affordances of multi-user virtual environments (MUVEs) as a platform to implement those strategies. EcoMUVE, a middle school curriculum for ecosystem science education, is presented as a case study to demonstrate the design of a MUVE-based curriculum that enhances science learning and engagement. The chapter concludes with a summary of research findings on student learning and engagement, and suggestions for consideration in implementing MUVE-based curricula in classrooms.