The role of saliva in maintaining oral homeostasis

Mandel, Irwin D.

doi:10.14219/jada.archive.1989.0211

Cited by 343 publications

(235 citation statements)

References 68 publications

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“…UWS flow represents the basal salivary output patients generate more than 90% of the day. Adequate unstimulated saliva flow is important for the preservation and maintenance of oral health (32,33). Importantly, UWS increases in patients given IFN alfa correlated significantly and positively with improvement in 7 of 8 symptom measures, suggesting that patients were able to perceive a clinical benefit related to this treatment.…”

Section: Cummins Et Almentioning

confidence: 97%

Treatment of primary sjögren's syndrome with low‐dose human interferon alfa administered by the oromucosal route: Combined phase III results

Cummins

Papas

Kammer

et al. 2003

Arthritis & Rheumatism

123

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Objective. This study tested the safety and efficacy of human interferon (IFN) alfa for treatment of salivary hypofunction and dry mouth symptoms in primary Sjö gren's syndrome patients. Methods. Combined results are reported from 2 phase III clinical trials in which a total of 497 subjects with primary Sjö gren's syndrome received 150 international units of human IFN alfa or matching placebo 3 times per day for 24 weeks by the oromucosal route. Results. Subjects given IFN alfa had a significantly (P ‫؍‬ 0.01) greater mean increase in unstimulated whole saliva (UWS) flow, compared with subjects given placebo. In IFN alfa patients, increases in UWS correlated positively and significantly with improvements noted in 7 of 8 symptoms associated with oral and ocular dryness. The coprimary endpoints of stimulated whole saliva flow and oral dryness were not significantly improved in the IFN alfa group relative to placebo. No significant differences were found between the groups with respect to overall adverse event incidence or severity. Conclusion. IFN alfa given at low dosage by the oromucosal route can significantly increase UWS flow in patients with primary Sjö gren's syndrome, without causing significant adverse events.

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Section: Cummins Et Almentioning

confidence: 97%

Treatment of primary sjögren's syndrome with low‐dose human interferon alfa administered by the oromucosal route: Combined phase III results

Cummins

Papas

Kammer

et al. 2003

Arthritis & Rheumatism

123

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“…Whole saliva is a mixture of secreted fluids having three main origins: the major and minor salivary glands (for ca 90%), and the gingival crevicular fluid (for ca 10%) by filtration through tight junctions, passive diffusion and exudation of plasma in the oral cavity (14,16). Accordingly, it constitutes a quite complex biological fluid containing a variety of both inorganic and organic components, such as minerals, lipids, growth factors, hormones and an array of proteins (10).…”

mentioning

confidence: 99%

“…Accordingly, it constitutes a quite complex biological fluid containing a variety of both inorganic and organic components, such as minerals, lipids, growth factors, hormones and an array of proteins (10). Whole saliva is known to have important physiological functions and to play a significant role in oral homeostasis (16). However, overall biochemical and molecular characterization of saliva remains quite limited, whilst such data would be highly desirable to increase our knowledge in terms of physiology.…”

mentioning

confidence: 99%

Complexity of the human whole saliva proteome

Hirtz

Chevalier

Centeno³

et al. 2005

J. Physiol. Biochem.

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“…8 Salivary flow is essential for these actions 9 and a reduction in salivary flow can lead to an increase in the occurrence of dental caries, oral infections, gastrointestinal complications, and a reduction in the quality of life. 10,11 Raquel Pippi ANTONIAZZI (a) Amanda Rodrigues SARI (b) Maísa CASARIN (c) Cristina Machado Bragança de MORAES (a) Carlos Alberto FELDENS (d) Hyposalivation is defined as an objective measure of a reduction in salivary flow and is associated with xerostomia, which is the subjective perception of dry mouth.…”

Section: Introductionmentioning

confidence: 99%

Association between crack cocaine use and reduced salivary flow

et al. 2017

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Abstract:Crack cocaine use appears to have an impact on oral conditions. However, changes in the salivary flow among crack users have not been fully clarified. The aim of this study was to compare stimulated salivary flow and the occurrence of hyposalivation between crack users and non-users. A cross-sectional study was conducted involving 40 crack users and 40 controls matched for sex, age, and smoking habits. Interviews were conducted to acquire data on the perception of dry mouth (xerostomia) and drug use. Stimulated salivary flow was determined using the spitting method. A significant reduction in stimulated salivary flow was found among crack users in comparison to non-users (1.02 vs. 1.59 ml/min). A total of 42.5% and 15% of crack users had very low and low stimulated salivary flow, respectively. Moreover, 65% of users reported xerostomia in comparison to 37.5% non-users (p < 0.012). No significant association was found between xerostomia and hyposalivation (p = 0.384). A multivariate analysis revealed that individuals older than 26 years of age, those with a low household income, and crack users (prevalence ratio: 2.59) had a significant association with the occurrence of hyposalivation. A significant association was found between the use of crack and reduced salivary flow. The use of crack was associated with the occurrence of hyposalivation in the multivariate analysis.

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The role of saliva in maintaining oral homeostasis

Cited by 343 publications

References 68 publications

Treatment of primary sjögren's syndrome with low‐dose human interferon alfa administered by the oromucosal route: Combined phase III results

Treatment of primary sjögren's syndrome with low‐dose human interferon alfa administered by the oromucosal route: Combined phase III results

Complexity of the human whole saliva proteome

Association between crack cocaine use and reduced salivary flow

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