The role of seasonality on the inhibitory effect of Brazilian green propolis on the oxidative metabolism of neutrophils

Simões-Ambrosio, Lívia Maria Cordeiro; Gregório, Luiz Elídio; Sousa, João Paulo Barreto de; Figueiredo-Rinhel, Andréa S.G.; Azzolini, Ana Elisa Caleiro Seixas; Bastos, Jairo Kenupp; Lucisano-Valim, Yara Maria

doi:10.1016/j.fitote.2010.07.008

Cited by 50 publications

(40 citation statements)

References 26 publications

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“…; rainfall and variations in temperature), could affect the chemical composition of propolis, investigations on the chemical composition and biological properties are important not only for academic interest, but also for the chemical and biological standardization of a particular type of propolis. 6 The studies with propolis in Brazil have been surrendering several scientific works. Due to great production of this material, the Brazil stands out as one of the largest world producers, has been generating interest of several national and international research groups.…”

Section: Introductionmentioning

confidence: 99%

Chiral Analysis of Monoterpenes in Volatile Oils From Propolis

Simionatto

Facco

Morel

et al. 2012

J. Chil. Chem. Soc.

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The essential oils obtained by hydrodistillation from samples of propolis manufactured in three regions of Rio Grande do Sul State at Brazil, were analyzed through CG, CG-MS and chiral phase gas chromatography (CPGC). These analyses display the presence of samples with elevated essential oil purport, when compared with plants. The yields obtained were until 3.8%. The samples exhibited similar composition, with predominance of the monoterpenes a-pinene (57-63%), b-pinene (12.5-30.8%) and limonene (1.5-11.2%). In chiral analysis of these constituents were observed modifications in the enantiomeric excess of isomers of a-pinene and limonene in relation with source location of the sample, already in the chiral analysis of b-pinene were detected only elevated excess of the enantiomer with the (-) configuration. The antimicrobial activity of the crude essential oil was assayed against five bacteria. The best result was obtained against Staphylococcus aureus.

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Section: Introductionmentioning

confidence: 99%

Chiral Analysis of Monoterpenes in Volatile Oils From Propolis

Simionatto

Facco

Morel

et al. 2012

J. Chil. Chem. Soc.

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“…Neste contexto, os produtos naturais têm recebido grande destaque nos últimos anos, uma vez que diversos estudos têm buscado substâncias naturais com efeito sobre o metabolismo oxidativo dos neutrófilos (Simões et al, 2004;Zekonis et al, 2008;Amaral et al, 2009;Paula et al, 2009;Simões-Ambrosio et al, 2010;Andrade et al, 2013;Barioni et al, 2013;Figueiredo-Rinhel et al, 2013;Flores et al, 2013;Kabeya et al, 2013;Denev et al, 2014;Figueiredo-Rinhel et al, 2014;Ren et al, 2014;Santos et al, 2014;Wang et al, 2014;Wickramasinghe et al, 2014;Liao et al, 2015).…”

Section: Discussionunclassified

“…Para isso, existe uma busca contínua por reguladores das funções efetoras desta célula, para que novos fármacos, com atividades anti-inflamatória e antioxidante, sejam produzidos. Estudos com produtos naturais têm demonstrado resultados satisfatórios e algumas substâncias com efeitos sobre o metabolismo oxidativo e sobre a desgranulação já foram identificadas (Zielinska et al, 2000;Kanashiro et al, 2007; _______________________________Introdução 14 Paula et al, 2009;Simões-Ambrosio et al, 2010;Andrade et al, 2013;FigueiredoRinhel et al, 2013;Ji et al, 2013;Kabeya et al, 2013;Figueiredo-Rinhel et al, 2014;Santos et al, 2014). Apesar de muitos destes produtos naturais terem grande potencial para serem usados como adjuvantes no tratamento da AR, estudos adicionais devem ser realizados para verificar se tais substâncias também interferem nos processos de reconhecimento e destruição dos micro-organismos pelos PMNs.…”

Section: Doença Inflamatória Com Envolvimento De Neutrófilos: Artriteunclassified

“…Este extrato foi selecionado devido à sua maior atividade antioxidante em ensaios de quimioluminescência realizados durante um estudo prévio de sazonalidade (Figueiredo, 2010;Figueiredo-Rinhel et al, 2013). Antes de iniciar os estudos deste trabalho, verificou-se que o EEBd manteve tanto o perfil químico quanto a atividade biológica do EEBd utilizado nos estudos prévios (Apêndice A).…”

Section: Extrato Etanólico Das Folhas De Baccharis Dracunculifolia (Eunclassified

“…Este método permite uma boa avaliação da cinética do metabolismo oxidativo dos PMNs, possibilitando o monitoramento do início, da amplitude e também do fim da produção das ERO (Dupre-Crochet et al, 2013). Além disso, como a produção de QL é dependente de ERO, este método tem sido empregado no estudo de substâncias com atividade antioxidante, sendo muito utilizado para a verificação da atividade antioxidante de produtos naturais em PMNs (Zielinska et al, 2000;Kanashiro et al, 2007;Simões-Ambrosio et al, 2010;Andrade et al, 2013;Czerwińska et al, 2013;Vongsak et al, 2013;Fernandes et al, 2014;Santos et al, 2014). Ji et al, 2013;Kabeya et al, 2013;Figueiredo-Rinhel et al, 2014;Santos et al, 2014).…”

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O extrato etanólico das folhas de Baccharis dracunculifolia (Asteraceae) modula funções efetoras de neutrófilos: um promissor agente fitoterápico para o tratamento de processos inflamatórios mediados por estas células

Rinhel¹

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RibeirãoNeutrophils are phagocytic immune cells mobilized primarily to fight against infections. These cells are capable to kill microorganisms through degranulation, which leads to the release of antimicrobial molecules, and production of reactive oxygen species. Although neutrophil recruitment is essential for host protection, excessive activation of these cells culminates in intense discharge of cytotoxic molecules to the extracellular milieu, which can elicit the development of and/or aggravate the clinical condition in autoimmune and inflammatory diseases such as rheumatoid arthritis. Modulation of the effector functions of neutrophils is a possible therapeutic approach to treat these diseases. Previous studies have shown that the ethanolic extract of Baccharis dracunculifolia leaves (EEBd) has a great therapeutic potential due to its significant antioxidant effect towards the oxidative metabolism of neutrophils. To continue investigating the anti-inflammatory and/or immunomodulatory action of such extract, the first part of the present work examined its modulator effect on three important effector functions of human neutrophils that mediate recognition and clearance of pathogens -phagocytosis, degranulation, and microbial killing -and on the activity of lysosomal enzymes. EEBd inhibited the oxidative metabolism of neutrophils without affecting their defense ability, depending on the extract concentration used. To propose possible chemical markers for the biological effects of the extract, the second part of this study evaluated the antioxidant activity of seven compounds isolated from EEBd -caffeic acid, coumaric acid, ferulic acid, cinnamic acid, aromadendrin-4'-methyl ether, isosakuranetin, and hispidulin -towards the oxidative metabolism of neutrophils. The results pointed to caffeic acid as a potential chemical marker for this biological activity. The third part of this investigation aimed to improve the bioavailability and favor the therapeutic use of the natural products studied. EEBd and caffeic acid were incorporated into liposomal carrier systems. The incorporation of both samples into liposomes did not alter their antioxidant activity towards neutrophils, as compared with their respective free forms. Finally, this study examined the therapeutic effect of EEBd and caffeic acid, both in the free form and incorporated into liposomes, in an animal model of arthritis. The free samples markedly improved the joint inflammatory parameters: they reduced edema and migration of total cells and neutrophils, and slightly lowered the levels of the inflammatory cytokines tumor necrosis factor  and interleukin 6 and 1 (TNF-, IL-6, and IL-1, respectively). In addition, incorporation of EEBd and caffeic acid into liposomes can help to reduce their concentrations required to achieve the desired therapeutic effect. Based on the set of results obtained in this study, we conclude that EEBd has a great potential to become a therapeutic adjuvant in the treatment of neutrophil-mediated inflammatory diseases, and that...

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Chemical composition and pharmacological properties of Macaranga‐type Pacific propolis: A review

Shahinozzaman

Obanda

Tawata

2020

Phytotherapy Research

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Propolis, a resinous substance, is collected from plants and processed by honeybees to seal holes and cracks in beehives, protecting them from microbial infection. Based on the plant source and geographical location, propolis is categorized into seven groups. Of these, Pacific propolis, found in the Pacific islands, originates from Macaranga spp. and is, therefore, known as Macaranga‐type Pacific propolis. Okinawa propolis and Taiwanese propolis, which are both Macaranga‐type propolis, are rich in prenylated flavonoids from the same botanical source, Macaranga tanarius, and are used locally as traditional remedies. They are reported to have a wide range of pharmacological benefits, including antioxidant, anti‐inflammation, antimicrobial, anticancer, antidiabetic, anti‐Alzheimer's, anti‐melanogenic, and longevity‐extending effects. However, not much is known about their mode of action, and recently, the extract of Okinawa propolis and its major prenylated flavonoids were found to selectively inhibit the oncogenic kinase, p21‐activated kinase 1 (PAK1). PAK1 enables cross‐talking among several signaling pathways, causing many diseases/disorders. The existing results reviewed here support the use of Macaranga‐type Pacific propolis for the effective development of safe herbal drugs and functional foods. Furthermore, its mode of action by modulating PAK1 can be explored, and the geographical and seasonal effects on its chemistry and biology, and its pharmacokinetics and toxicology should be studied as well.

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The role of seasonality on the inhibitory effect of Brazilian green propolis on the oxidative metabolism of neutrophils

Cited by 50 publications

References 26 publications

Chiral Analysis of Monoterpenes in Volatile Oils From Propolis

Chiral Analysis of Monoterpenes in Volatile Oils From Propolis

O extrato etanólico das folhas de Baccharis dracunculifolia (Asteraceae) modula funções efetoras de neutrófilos: um promissor agente fitoterápico para o tratamento de processos inflamatórios mediados por estas células

Chemical composition and pharmacological properties of Macaranga‐type Pacific propolis: A review

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