The role of sensory neurons in the antiulcer effect of centrally injected amylin in rat

Guidobono, F.; Pagani, F.; Sibilia, V.; Soglian, A.; Rapetti, D.; Netti, C.

doi:10.1016/s0196-9781(00)00308-9

Cited by 11 publications

(6 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…If the mucosal barrier is disturbed or disrupted in the presence of luminal acid, the surge of acid intruding into the lamina propria stimulates spinal afferents, which cause prompt hyperemia in the gastroduodenal mucosa via local CGRP release and NO formation [5]. Meanwhile, a neurotoxic dose of capsaicin causes a longlasting deactivation of sensory neurons, so-called capsaicin desensitization, and this condition exacerbates mucosal lesion formation by irritating factors such as stress and ethanol [5] and offers an excellent model for the study of sensory nerves with the gastroprotection of various agents [9,[20][21][22][23][24][25][26][27][28]. In the present study, the increased gastric tissue expression of CGRP was enhanced by pretreatment with SK-MS10, and was inhibited by capsaicin desensitization.…”

Section: Discussionmentioning

confidence: 99%

Gastroprotective Action of Cochinchina Momordica Seed Extract Is Mediated by Activation of CGRP and Inhibition of cPLA2/5-LOX Pathway

Kang

Kim

et al. 2009

Dig Dis Sci

View full text Add to dashboard Cite

Cochinchina momordica seed extract (SKMS10), which is composed of the major compounds momordica saponins, has been evaluated for its gastroprotective effects in rat models of acute gastric mucosal damage. Ethanol and water immersion restraint stress (WRS) induced gastric damage, including hemorrhages and edema, was significantly attenuated by pretreatment with SK-MS10. In addition, SK-MS10 reduced increases of mucosal myeloperoxidase (MPO), IL-1β, and TNFα levels and the expression of cPLA(2), and 5-LOX induced by ethanol or WRS. SK-MS10 also increased hexosamine, adherent mucus, and the expression of MUC5AC. Furthermore, SK-MS10 enhanced the mucosal expression of the CGRP gene and its serum levels.N(G)-methyl L-arginine (L-NMMA) or capsaicin desensitization reversed the SK-MS10-induced gastroprotection effect. These results suggest that SK-MS10 is a gastroprotective agent against acute gastric mucosal damage by suppressing proinflammatory cytokines, downregulating cPLA(2), 5-LOX, and increasing the synthesis of mucus. Furthermore, CGRP-NO pathway was found to play an important role in these gastroprotective effects of SK-MS10.

show abstract

Section: Discussionmentioning

confidence: 99%

Gastroprotective Action of Cochinchina Momordica Seed Extract Is Mediated by Activation of CGRP and Inhibition of cPLA2/5-LOX Pathway

Kang

Kim

et al. 2009

Dig Dis Sci

View full text Add to dashboard Cite

show abstract

“…Yohimbine pretreatment attenuates the protective effect of clonidine [26,27], agmatine [28], intragastric polyethylene glycol 400 [29], and clarithromycin [30] against ethanolinduced gastric mucosal injury and the protective effect of centrally administered amylin against indomethacin injury [31]. The mechanism of yohimbine in blocking the gastric protective effect of these treatments is not fully understood.…”

Section: Discussionmentioning

confidence: 99%

Involvement of α2-Adrenoceptors in the Gastric Protective Effect of Nitroglycerin Against Acidified Ethanol-Induced Mucosal Injury

Leung

Chan

2007

Dig Dis Sci

View full text Add to dashboard Cite

Clinical observations reveal that alcohol intake is associated with an increase in upper gastrointestinal hemorrhage requiring hospitalization and that nitroglycerin or long-acting nitrates lower this risk. Nitroglycerin, a gastric vasodilator that can increase gastric fluid volume, protects the rodent stomach against damage, including that caused by 70% ethanol. Blockade of alpha(2)-adrenoceoptors attenuates gastric protection by intragastric nicotine against 40% ethanol. We tested the hypothesis that the protective effect of nitroglycerin is mediated by an increase in gastric fluid volume and alpha(2)-adrenoceoptors. Nitroglycerin, 5 mg/kg, vehicle, or acidified ethanol was administered intragastrically. In study 1 acidified ethanol-induced mucosal injury was measured. In study 2 the effect of increasing gastric volume (1 ml/kg) on mucosal injury was assessed. In study 3 the effect of yohimbine (alpha(2)-adrenoceoptor antagonist), 5 mg/kg subcutaneously, on the nitroglycerein-mediated protective effect was determined. Results showed that nitroglycerin significantly attenuated the number and length of mucosal lesions induced by acidified ethanol. Increase in gastric fluid volume by exogenously administered saline did not alter the protective effect. Yohimbine blocked the nitroglycerin-mediated protection. These experimental data are consistent with the observation that nitrates lower the risk of ethanol-induced gastrointestinal complications. alpha(2)-Adrenoceoptors are responsible in part for the protective effect of nitroglycerin.

show abstract

“…Hereafter, additional neuropeptides proved to be gastroprotective given centrally, among others adrenomedullin [128] peptide YY [129] amylin [130], leptin, cholecystokinin [131], ghrelin [132], opioids, e.g. β-endorphin, deltorphin II, endomorphins [4,133] nociceptin, nocistatin [134], TLQP-21, a VGF-derived peptide [135], substance P [136] and angiotensin II [137] (see reviews: [4,127,138]).…”

Section: Role Of Capsaicin Sensitive Afferent Fibers and In The Actiomentioning

confidence: 99%

The Role of Capsaicin-Sensitive Afferent Nerves in Gastric Mucosal Protection Initiated Centrally or Peripherally under Experimental Conditions

Gyires¹

2014

Capsaicin - Sensitive Neural Afferentation and the Gastrointestinal Tract: From Bench to Bedside

View full text Add to dashboard Cite

The role of sensory neurons in the antiulcer effect of centrally injected amylin in rat

Cited by 11 publications

References 26 publications

Gastroprotective Action of Cochinchina Momordica Seed Extract Is Mediated by Activation of CGRP and Inhibition of cPLA2/5-LOX Pathway

Gastroprotective Action of Cochinchina Momordica Seed Extract Is Mediated by Activation of CGRP and Inhibition of cPLA2/5-LOX Pathway

Involvement of α2-Adrenoceptors in the Gastric Protective Effect of Nitroglycerin Against Acidified Ethanol-Induced Mucosal Injury

The Role of Capsaicin-Sensitive Afferent Nerves in Gastric Mucosal Protection Initiated Centrally or Peripherally under Experimental Conditions

Contact Info

Product

Resources

About